APOQUEL: A different class of medication that specifically targets the cytokines involved in itch and inflammation associated with allergic skin conditions with minimal negative impact on immune function4
How does APOQUEL work?
APOQUEL inhibits the function of a variety of pruritogenic and proinflammatory cytokines, as well as cytokines involved in allergy that are dependent on JAK1 or JAK3 enzyme activity4
APOQUEL has minimal effect on JAK2-dependent cytokines involved in hematopoiesis and innate immunity4
APOQUEL is not a corticosteroid, antihistamine or cyclosporine
Control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.
Important Safety Information
Do not use APOQUEL in dogs less than 12 months of age or those with serious infections. APOQUEL may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. APOQUEL has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. APOQUEL has been used safely with many common medications including parasiticides, antibiotics and vaccines.
Reference: 4. Gonzales A, Bowman J, Fici G, Zhang M, Mann D, Mitton-Fry M. Oclacitinib (Apoquel®) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. J Vet Pharmacal Ther. August 2014;37(4):317-324.