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The PI3 virus infects the upper respiratory mucosa, where it is shed in aerosols and by direct contact. The role of PI3 in BRD is to predispose cattle to concurrent infections with IBR virus or bacterial respiratory pathogens.
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Clinical effects include the classic respiratory signs of cough, fever, serous nasal and ocular discharge, increased respiratory rate and dyspenea (difficult breathing).
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Diagnosis may be made on clinical signs typical of viral respiratory disease, including fever, depression, inappetance, nasal discharge, spontaneous coughing, and increased respiratory rate.
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There is no specific anti-PI3 therapy. Treatment is limited to antibacterial therapy for secondary bacterial infections and supportive treatment.
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Vaccination with TSV-2®, INFORCE™ 3, Bovi-Shield GOLD® 4, Bovi-Shield GOLD® 5, Bovi-Shield GOLD FP® 5 L5 HB, Bovi-Shield GOLD FP® 5, Bovi-Shield GOLD FP® 5 L5, Bovi-Shield GOLD FP® 5 VL5, CattleMaster® 4+VL5, CattleMaster® GOLD FP® 5, CattleMaster® GOLD FP® 5 L5, PregGuard GOLD FP® 10 may help prevent, control, or lessen the severity of the disease.
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TSV-2®
INFORCE™ 3
Bovi-Shield GOLD® 4
Bovi-Shield GOLD® 5
Bovi-Shield GOLD FP® 5 L5 HB
Bovi-Shield GOLD FP® 5
Bovi-Shield GOLD FP® 5 L5
Bovi-Shield GOLD FP® 5 VL5
CattleMaster® 4+VL5
CattleMaster® GOLD FP® 5
CattleMaster® GOLD FP® 5 L5
PregGuard GOLD FP® 10
*LABEL INDICATIONS: Do not use in pregnant cattle (abortions can result) unless they were vaccinated, according to label directions, with any BOVI-SHIELD GOLD FP or PREGGUARD GOLD FP vaccine prebreeding initially and within 12 months thereafter. Do not use in calves nursing pregnant cows unless their dams were vaccinated within the past 12 months as described above. To help ensure safety in pregnant cattle, heifers must receive at least 2 doses of any BOVI-SHIELD GOLD FP or PREGGUARD GOLD FP vaccine with the second dose administered approximately 30 days prebreeding.
United States 
