New understanding of the pathobiology of canine pruritus is helping to improve treatments
Welcome to itchcycle.com, a resource for learning about the cycle of itch and its role in canine pruritus.
The itch cycle begins when allergens cross the skin barrier, triggering T-cell activation and sensitization of immune cells. When re-exposed to the allergen, these cells release pruritogenic and pro-inflammatory cytokines, causing scratching and starting the cycle again.
Evolving understanding of the biochemical pathways of the itch cycle may lead to precisely targeted treatments designed to interrupt the cycle and halt itch. To learn more, review the videos below.