Vaccination Can Lock Out BRD on Arrival

Program including INFORCE 3® leads to better herd health for Kansas cattleman

In Allen, Kansas, Brian Keith leads a diversified cattle business with cattle sourced from a variety of places and grown for many purposes and customers. His success depends on managing the stress cattle experience from transportation and co-mingling.  

So, Keith started administering INFORCE 3®respiratory vaccine and ONE SHOT® BVD to cattle on arrival, based on the advice of his veterinarian and a consultant from Zoetis. The difference it made against helping prevent respiratory illness and bovine respiratory disease (BRD) was clear.

“We’ve gotten along a lot better with it ever since,” said Keith, who operates Keith Cattle Company along with his wife, Lisa and their son and daughter-in-law, Justin and Kelsey, and two additional full-time staff and some part-time help.

Preventing BRD 
BRD is the No. 1 cause of death across all classes of cattle, including stocker and feedlot cattle.1 It increases labor and medication costs and accounts for $1 billion in losses due to forfeited production.2,3

However, like others using INFORCE 3 along with ONE SHOT BVD, Keith helps provide his cattle with complete protection against key respiratory diseases.4,5 In addition to administering it to cattle sourced from elsewhere, Keith uses INFORCE 3 at branding on all home-raised calves at Keith Cattle Company — it’s the first product they get, he said. Keith said he’s noticed a better response in those calves to respiratory vaccines, a better level of immunity and generally improved respiratory health.4

Reduce illness and reduce the need to treat 
The numbers support the success INFORCE 3® can offer by preventing respiratory illness and reducing treatments for bovine respiratory disease.

  • Immunosuppressed cattle demonstrated equivalent or greater innate and adaptive local immune responses to infectious bovine rhinotracheitis (IBR) than those vaccinated up to 12 days before stressful events.5   
  • High-risk cattle vaccinated on arrival with INFORCE 3 and ONE SHOT® BVD
         demonstrated a 41% reduction in second BRD treatments and a 45% reduction in third BRD treatments compared with calves that received Vista® Once SQ.6  
Cattle producers can also have confidence that INFORCE 3 delivers at least six months of immunity against IBR in addition to preventing bovine respiratory syncytial virus respiratory disease.
Consult your veterinarian about how to design a vaccination program to protect your cattle from respiratory disease challenges. And visit for full details about INFORCE 3 and the potential it offers for your herd. 
About Zoetis
Zoetis is the leading animal health company, dedicated to supporting its customers and their businesses. Building on more than 65 years of experience in animal health, Zoetis discovers, develops, manufactures and commercializes medicines, vaccines and diagnostic products, which are complemented by biodevices, genetic tests and precision livestock farming. Zoetis serves veterinarians, livestock producers and people who raise and care for farm and companion animals with sales of its products in more than 100 countries. In 2019, the company
generated annual revenue of $6.3 billion with approximately 10,600 employees. For more information, visit
For more information, contact:
Leona Ferguson
Lori Maude
Bader Rutter
1 U.S. Department of Agriculture. Cattle and Calves Nonpredator Death Loss in the United States, 2010.
Published December 2011. Accessed December 8, 2016.
2 Brodersen BW. Bovine respiratory syncytial virus. Vet Clin North Am Food Anim Pract. 2010;26(2):323- 333. 
3 Griffin D, Chengappa MM, Kuszak J, McVey DS. Bacterial pathogens of the bovine respiratory disease complex. Vet Clin North Am Food Anim Pract. 2010;26(2):381-394.
4 Stokka GL, Neville B, Seeger JT, Stoltenow C, Dyer N, Gaspers JJ. Evaluation of the serologic effect of concurrent IBR, BRSV, PI3 and Mannheimia vaccination and time interval between the first and second dose on the subsequent serological response to the Mannheimia toxoid and BRSV fractions on spring- born beef calves in North Dakota. North Dakota Beef Report. 2014;40-42.
5 Cortese V, Woolums A, Hurley D, Bernard J, Berghaus R, Short T. Comparison of interferon and BoHV1 IgA levels in nasal secretions of dairy cattle vaccinated with Inforce 3 prior to calving or on day of calving, in Proceedings. 29th World Buiatrics Congress 2016;436.
6 Step DL, Krehbiel CR, Hixon C, et al. Evaluation of Commercially Available Multivalent Modified-Live Viral Vaccines on Health and Performance in Feedlot Cattle. JJ Vaccine Vaccination. 2015;1(3):1-8.



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