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Role Of NGF In OA Pain

Studies have identified a new key player in the transmission of pain associated with osteoarthritis (OA) in people, dogs and cats.1,2 In adults, Nerve Growth Factor (NGF) plays a significant role in pain signaling. Watch the video below to watch the newly identified mechanism of action of Nerve Growth Factor in OA pain.

NGF in Osteoarthritis Pain
Duncan Lascelles, BSc, BVSc, PhD, FRCVS, CertVA, CertSAS, discusses the clinical implications of NGF for osteoarthritis pain.

NGF in Central Sensitization
Duncan Lascelles, BSc, BVSc, PhD, FRCVS, CertVA, CertSAS, discusses the clinical implications of NGF for central sensitization.

The Experience of Osteoarthritis Pain
If you can get to the understanding that chronic pain takes on a life of its own regardless of the initiator, then they can understand that you have to manage it. Dr. Steve Budsberg, DVM, MS, DACVS

A panel of experts convened to discuss the latest science describing the progression, clinical implications, and treatment options for chronic osteoarthritis pain in cats and dogs. These proceedings capture their thoughts and insights about what we know and how they communicate this knowledge to pet owners. Also included is a Chronic Pain Pet Owner Teaching Tool.


Pain Progression Pet Owner Teaching Tool

Hear panel members’ reflections after their meeting.

How would you describe the pain experience?

What is the central sensitization?

How What makes osteoarthritis pain complex?

How do you explain the complexity of the clinical pain response?

References: 1. Chang DS, et al, Anti-nerve growth factor in pain management: current evidence. J Pain Res. 2016;9:373‐383 (AR-10511). 2. Enomoto, M., Mantyh, PW., Murrell, J., Innes, JF., Lascelles, BDX. (2019) Anti-nerve growth factor monoclonal antibodies for the control of pain in dogs and cats. Veterinary Record 184, 23 (AR-08011).



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Other Resources

Anti-NGF monoclonal antibodies as a prospective new therapy for feline and canine osteoarthritis

Read a paper published in Veterinary Record (January 5, 2019) that reviews the science behind NGF and the potential veterinary treatments based on this novel pathway by Masataka Enomoto, DVM.



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