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For use in synchronization programs with LUTALYSE®

Delays in rebreeding can be costly. Synchronization programs with producer- and veterinarian-trusted products from Zoetis result in more efficient breeding, saving time and protecting your bottom line. FACTREL® Injection (gonadorelin injection) has an FDA-approved label to be used in conjunction with LUTALYSE® Injection (dinoprost injection) to synchronize estrous cycles to allow for fixed-time artificial insemination (FTAI) in lactating dairy cattle.

FACTREL is now available in a larger, more convenient 50-mL bottle. Now you can treat up to 25 cows per bottle of FACTREL compared with just 10 doses in the 20-mL bottle. With more than 12,000 total cows studied, you can have confidence that FACTREL is effective. Now you can adapt a reproduction program that fits your management needs, with flexible schedule and dosing with FACTREL and LUTALYSE.

FACTREL is also indicated for the treatment of ovarian follicular cysts in cattle. When used in cattle with ovarian follicular cysts, treatment effect is to reduce the number of days to next estrus.  

It’s more than just the bottle. Zoetis works with you to make appropriate decisions about the use of LUTALYSE and FACTREL in your herds and to create a comprehensive approach for your reproduction program, so you can set and achieve higher pregnancy rate goals, improving your milk production and increasing the opportunities you have for herd improvement through genetic selection.

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  • FACTREL is approved for use with LUTALYSE to synchronize estrous cycles to allow FTAI:

    • Consistent with protocols recommended by the Dairy Cattle Reproduction Council
    • Flexible treatment regimens to meet needs of individual operations
    • Improves breeding efficiency

    For treatment of ovarian follicular cysts in cattle:

    • Treat infertility due to ovarian cysts
    • Number of days to next estrus is reduced
    • Better utilization of AI genetics when cows are prepared for insemination through resolution of follicular cysts
  • The recommended dosage of FACTREL for use with LUTALYSE to synchronize estrous cycles to allow fixed-time artificial insemination is 2 to 4 mL/cow intramuscularly.

    Below are three examples of treatment regimens for FTAI with FACTREL and LUTALYSE.


    Example 1

    Example 2

    Example 3

    Day 0 (Monday)

    1st FACTREL

    1st FACTREL

    1st FACTREL

    Day 7 (the following Monday)




    Day 9 (Wednesday)

    2nd FACTREL + FTAI at 48 hours after LUTALYSE

    2nd FACTREL 48 hours after LUTALYSE

    2nd FACTREL 56 hours after LUTALYSE

    Day 10 (Thursday)


    FTAI 24 hours after 2nd FACTREL

    FTAI 16 hours after FACTREL

    The recommended dosage of FACTREL for the treatment of ovarian follicular cysts in cattle is 2 mL/cow intramuscularly.

    FACTREL is available in a 20-mL vial (10 doses) and a 50-mL vial (25 doses). 

IMPORTANT SAFETY INFORMATION FOR FACTREL: FACTREL is for use in cattle only. See full Prescribing Information.

IMPORTANT SAFETY INFORMATION FOR LUTALYSE: Women of childbearing age and persons with respiratory problems should exercise extreme caution when handling LUTALYSE. LUTALYSE is readily absorbed through the skin and may cause abortion and/or bronchiospasms, therefore spillage on the skin should be washed off immediately with soap and water. Aseptic technique should be used to reduce the possibility of post-injection clostridial infections. Do not administer LUTALYSE in pregnant cattle unless cessation of pregnancy is desired. See full Prescribing Information.




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