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Fetal Protection Matters


Reproductive Diseases Can Be Costly

The reproductive forms of the following viral diseases can pose a threat to profitability:

Bovine viral diarrhea (BVD)

  • Caused by bovine viral diarrhea virus Types 1 and 2
  • Can lead to abortion, fetal death/resorption and/or congenital malformation of the fetus
  • Fetal infection can result in the birth of weak or BVD persistently infected (PI) calves 1
  • BVD PI cattle can serve as a long-term source of infection for the herd

Infectious bovine rhinotracheitis (IBR)

  • Caused by bovine herpesvirus 1 (BoHV-1) which is commonly referred to as IBR virus
  • Can lead to sporadic abortions and abortion storms 1
  • The virus can hide in the body and be reactivated when cattle are stressed or injured
  • Viral shedding can lead to infection of other cattle
Loss of Up To $93.52Per Head
Due to decreased performance and fatalities when cattle are exposed to BVD PI cattle 2
More Than
More Costly
Than respiratory diseases 3
Up To 60%
of Herd
By abortion storms during IBR outbreaks

Set Cattle Up For A Lifetime of Success

An effective reproductive vaccine program, coupled with good nutrition, can help heifers conceive earlier and potentially extend the length of their productive lives. In fact, research shows that heifers that conceive in the first 21-day breeding period demonstrate increased longevity. 4

Delivering More Ways To Protect Your Unborn Calves

A three-year study evaluated the efficacy of pre-breeding vaccination with BOVI-SHIELD GOLD FP ® 5, an MLV vaccine, and then annual revaccination with the same product or a transition to CATTLEMASTER GOLD FP ® 5, a vaccine with the efficacy of an MLV vaccine but the safety of a fully killed vaccine, at pregnancy check. 5


Sequential infectious exposure to BVD virus types 1a, 1b and 2 followed by IBR virus subjected pregnant cows to a very severe reproductive challenge:

  • The challenges resulted in fetal infection of 100% (15/15) of the control group.
  • In 47% (7/15) of the aborted calves, both IBR and BVD virus were isolated. 5
  • Both vaccine programs provided significantly high levels of protection against virulent BVD and IBR exposure (P < 0.0001). 5

While BOVI-SHIELD GOLD FP can provide an effective pregnant cow vaccination program, if you need more flexibility, CATTLEMASTER GOLD FP offers an any cow, anytime option with no loss in vaccine efficacy for either IBR abortion or BVD types 1 and 2 Persistent Infection.



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See why all fetal protection vaccines aren't the same.

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Watch how Zoetis ensures reproductive vaccine safety.

Protecting Calves Before Day One

Watch the prerecorded webinar about an immunization program that offers high levels of protection and convenience.

Webinar Leaders

Paul H. Walz profile picture

Paul H. Walz, DVM, MS, PhD, Diplomate, ACVIM

Professor and Coordinator, Animal Health Research Department of Pathobiology

College of Veterinary Medicine, Auburn University

Daniel W. Scruggs profile picture

Daniel W. Scruggs, DVM, Diplomate, ACVP

Managing veterinarian, Zoetis Technical Services

Webinar Q&A


Based on the overall results, should I change to CATTLEMASTER GOLD? It looks like the protection was better.


Summary of Dr. Walz’s Reply: The results from this study indicate that both vaccination programs are highly efficacious. We did see better protection with the CATTLEMASTER GOLD FP revaccination program, but those weren’t statistically significant differences.


Does this mean I can expect the same results giving other all killed vaccines?


Summary of Dr. Scruggs’ Reply: None of the other killed vaccines have labels for fetal protection against IBR or BVD. There have been assertions that other killed vaccines will provide the same level of protection, but at some point they’re going to have to prove that before producers and veterinarians are going to invest the money.


What will happen three to four years down the road. What kind of protection might I anticipate if I stay on CATTLEMASTER GOLD FP and never use MLV in those cows after the heifer vaccination.


Summary of Dr. Walz’s Reply: Modified-live viral vaccines do a great job of stimulating both arms of the immune system. They stimulate antibody production but they also stimulate a cell-mediated immune response. Killed vaccines generally only stimulate a humoral, or antibody, response.

In our study, when we administered the inactivated BVD viral component and the temperature-sensitive modified-live viral component of CATTLEMASTER GOLD FP, we did stimulate tremendous humoral immunity in those animals. But what we don’t know is how well we’re stimulating the cell portion of the immunity.


Can I give a modified-live viral vaccine to the calves nursing pregnant cows vaccinated this way?


Summary of Dr. Scrugg’ Reply: According to label, if the nursing calf is to be administered a modified-live viral vaccine, that cow needs to have received the same modified-live viral vaccine within the previous 12 months. It’s really a call for the veterinarian overseeing the herd.


Depending on weather and other priorities, I find myself working heifers at different ages from those in the study. How wide is my window of opportunity to give them two doses of BOVI-SHIELD GOLD FP prior to breeding?


Summary of Dr. Scrugg’ Reply: The width of the time between vaccinations is not that important. The key vaccine for heifers is the dose that occurs 30 to 40 days prior to breeding. That’s the important dose in terms of efficacy and safety if that heifer’s going to receive BOVI-SHIELD GOLD FP as a pregnant cow.

  1. Smith BP. Large Animal Internal Medicine, 5th ed. St. Louis, MO: Mosby; 2014.
  2. Hessman BE, Fulton RW, Sjeklocha DB, Murphy TA, Ridpath JF, Payton ME. Evaluation of economic effects and the health and performance of the general cattle population after exposure to cattle persistently infected with bovine viral diarrhea virus in a starter feedlot. Am J Vet Res. 2009:70(1):73-85.
  3. Bellows DS, Ott SL, Bellows RA. Review: Cost of Reproductive Diseases and Conditions in Cattle. Prof Anim Sci. 2002;18(1):26-32.
  4. Mousel EM, Cushman RA, Perry GA, Kill LK. Effect of heifer calving date on longevity and lifetime productivity, in Proceedings. Appl Repro Strat in Beef Cattle 2012;23-31.
  5. Walz PH, Givens MD, Rodning SP, et al. Evaluation of reproductive protection against bovine viral diarrhea virus and bovine herpesvirus-1 afforded by annual revaccination with modified-live viral or combination modified-live/killed viral vaccines after primary vaccination with modified-live viral vaccine. Vaccine. 2017;35(7):1046-1054.