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Flexibility to Fit Your Plans

Used concurrently, INFORCE 3® and ONE SHOT® BVD give you flexibility to vaccinate according to your schedule. They combat harmful bovine respiratory disease (BRD) pathogens and give calves a healthy start:

  • Rapid immune response — Intranasal administration of INFORCE 3® stimulates a rapid immune response where respiratory infections begin.1
  • More complete immune response — A study showed that INFORCE 3® did not result in infectious bovine rhinotracheitis (IBR) dominant antigen interference with injectable Mannheimia haemolytica vaccines.2
  • Superior respiratory protection — INFORCE 3® and ONE SHOT BVD offer the highest label claims in their categories.


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  • Comprehensive bovine respiratory disease protection

    Together, the trusted performance of INFORCE 3® and ONE SHOT BVD helps protect calves from the most damaging pathogens associated with BRD:

    • Bovine respiratory syncytial virus (BRSV)
    • Infectious bovine rhinotracheitis (IBR) virus
    • Parainfluenza 3 (PI3) virus
    • Mannheimia haemolytica
    • Bovine viral diarrhea (BVD) Types 1 and 2 viruses


    Fewer re-treatments, better profits

    In a study, the use of INFORCE 3® boosted with Bovi-Shield GOLD 5 and ONE SHOT BVD significantly reduced (p = 0.01) second and third BRD re-treatments compared with Vista® Once boosted with Vista 5 SQ.3 Differences in treatments and mortalities resulted in greater total costs per head compared to Inforce 3 + Bovi-Shield GOLD 5.

    • Cattle receiving Vista Once SQ / Vista 5 SQ resulted in $32.40 more per head in total costs.3
    • Cattle given Pyramid 5 + Presponse SQ had $16.78 more per head in total costs.3
  • INFORCE 3®
    INFORCE 3 has been demonstrated to be safe for use in all ages and classes of cattle. That includes high-stress nursing calves, weaned calves, high-stress stocker cattle and pregnant heifers and cows.


    • Aseptically rehydrate the freeze-dried vaccine with the sterile diluent provided and shake well.
    • Administer 2 mL intranasally using a cannula or a syringe with the needle removed.
    • Place half the dose (1 mL) in each nostril, or 2 mL in one nostril.

    Calves vaccinated before the age of 6 months should be revaccinated after 6 months of age to avoid possible maternal antibody interference with immunization. Annual revaccination with a single dose is recommended.


    ONE SHOT BVD may be administered to pregnant cattle provided they were vaccinated, according to label directions, with any BOVI-SHIELD GOLD® FP or PREGGUARD GOLD® FP vaccine within the past 12 months. ONE SHOT BVD also may be administered to calves nursing pregnant cows provided their dams were vaccinated within the past 12 months as described above. To help ensure safety in pregnant cattle, heifers must receive at least two doses of any BOVI-SHIELD GOLD FP or PREGGUARD GOLD FP product with the second dose administered approximately 30 days prebreeding.



    • Vaccination of healthy cattle is recommended.
    • Aseptically rehydrate the freeze-dried vaccine with the sterile diluent provided and shake well.
    • Administer 2 mL subcutaneously in the neck region, in accordance with Beef Quality Assurance guidelines.

    To avoid possible maternal antibody interference with active immunization, calves vaccinated before the age of 6 months should be revaccinated after 6 months of age or at weaning. Annual revaccination with a single dose is recommended. Good management practices support revaccination whenever subsequent stress or exposure is likely.

  • 1 Ellis JA, Gow SP, Mahan S, Leyh R. Duration of immunity to experimental infection with bovine respiratory syncytial virus following intranasal vaccination of young passively immune calves. J Am Vet Med Assoc. 2013;243(11):1602-1608.

    2 Stoltenow CL, Cortese VS, Seeger JT, Stokka GS, Weigel D. Immunologic response of beef calves to concurrent application of modified-live viral vaccine (intranasal and systemic administration) and systemically administered Mannheimia haemolytica bacterin-leukotoxoid. Bovine Pract. 2011;45(2):132-138.

    3 Step DL, Krehbiel CR, Hixon C, Blanding MR, Hilbig DR, Cortese VS, Short TH. Evaluation of Commercially Available Multivalent Modified-Live Viral Vaccines on Health and Performance in Feedlot Cattle. JJ Vaccine Vaccination. 2015; 1(3): 1-8.

    Pyramid® and Presponse® are registered trademarks of Boehringer Ingelheim Vetmedica, Inc. Vista® is the registered trademark of Intervet Inc. or an affiliate.




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