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Mannheimia haemolytica Bacterin-Toxoid

One Shot

One Shot® is a bacterin-toxoid for vaccination of healthy cattle as an aid in preventing bovine pneumonia caused by Mannheimia haemolytica type A1. One Shot is an inactivated, freeze-dried product prepared from whole cultures propagated to increase the production of leukotoxin and capsular and cell-associated antigens. A sterile diluent containing adjuvant to enhance the immune response is used to rehydrate the freeze-dried bacterin-toxoid.

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  • Uses: Aids in the prevention of bovine pneumonia caused by Mannheimia haemolytica Type A1.

    Key Features:

    • Helps protect against the primary cause of respiratory death in cattle, shipping fever and pneumonia caused by Mannheimia haemolytica Type A1.
    • Contains killed bacterial culture plus a toxoid.
    • Produces leukotoxin and whole-cell antibody responses, helping provide protection needed to withstand Mannheimia haemolytica challenge.
    • Single subcutaneous (SC) dose is 2 mL.

    Safety and Efficacy

    One Shot is considered safe in cattle of all ages. Following vaccination, animals remained alert and exhibited no signs of pain or soreness. The product was observed to cause moderate swelling at the injection site in some animals, primarily in dairy calves. Resolution occurred in most cases within 14-28 days; while in a few animals, small swelling was noticeable 60 days post vaccination.  Efficacy of One Shot was demonstrated in challenge-of-immunity studies. Cattle (400-550 lb) vaccinated with one dose of One Shot were subjected to severe experimental challenge at two weeks post vaccination with a heterologous strain of M. haemolytica type A1. Six days post-challenge, animals were necropsied and individual lungs were evaluated for lung damage and lesions characteristic of M. haemolytica type A1 infection. Subcutaneous vaccinates demonstrated statistically significant reduction in lung damage compared to placebo controls.

  • Packaging: 5-, 10- and 50-dose vials.


    1. General directions: Vaccination of healthy cattle is recommended. Aseptically rehydrate the freeze-dried bacterin-toxoid with the accompanying adjuvant-containing sterile diluent, shake well, and administer 2 mL subcutaneously. In accordance with Beef Quality Assurance guidelines, this product should be administered subcutaneously (SC) under the skin. Healthy cattle should be vaccinated a minimum of 14 days prior to weaning, shipping, or exposure to stress or infectious conditions.
    2. Primary vaccination: Administer a single dose to healthy cattle. Only a single dose is necessary to confer active immunity. Good management practices support revaccination whenever subsequent stress or exposure is likely.
    3. Good animal husbandry and herd health management practices should be employed.
  • Precautions:

    1. Store at 2°-7°C. Prolonged exposure to higher temperatures may adversely affect potency. Do not freeze.
    2. Use entire contents when first opened.
    3. Sterilized syringes and needles should be used to administer this bacterin-toxoid.
    4. Do not vaccinate within 21 days before slaughter.
    5. As with many vaccines, anaphylaxis may occur after use. Initial antidote of epinephrine is recommended and should be followed with appropriate supportive therapy.
    6. This product has been shown to be efficacious in healthy animals. A protective immune response may not be elicited if animals are incubating an infectious disease, are malnourished or parasitized, are stressed due to shipment or environmental conditions, are otherwise immunocompromised, or the bacterin-toxoid is not administered in accordance with label directions.



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