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CYTOPOINT - now approved for the treatment of allergic dermatitis! Learn more

Tailor your approach—talk to your client about 2 best-in-class options for relief: CYTOPOINT and APOQUEL (oclacitinib tablet)

With CYTOPOINT, a single in-office injection offers 4 to 8 weeks of relief,* giving damaged skin a chance to heal and helping to improve the quality of life for dogs
and their families¹
Both APOQUEL and CYTOPOINT have distinct advantages for relieving allergic itch
These 2 options can also be used together to complement each other

For rapid itch relief you can start and stop

APOQUEL controls pruritus associated with allergic dermatitis and controls atopic dermatitis in dogs at least 12 months of age

Starts providing itch relief within 4 hours, protecting the bonds that matter most²

Targets itch and inﬂammatory cytokines, resulting in signiﬁcant reduction of pruritus and inﬂammation³

Can be used long term for maintenance therapy and with many other medications, including NSAIDs, anti-infectives, parasiticides, antifungals and allergen-speciﬁc therapy^4†

Allows ﬂexibility to stop and start control of pruritus quickly—as necessary—for assessments during the diagnostic workup (eg, ﬂea and food trials)

APOQUEL is a great choice for:

rapid allergic itch relief⁴

start-and-stop itch control

use during diagnostic tests⁷

dogs at least 12 months of age

short- and long-term management of itch

†The use of APOQUEL has not been evaluated in combination with other systemic immunosuppressants, such as corticosteroids and cyclosporine

For sustained long lasting relief

CYTOPOINT has been shown to be effective for the treatment of dogs against allergic dermatitis and atopic dermatitis

Begins to relieve itch within 24 hours and lasts for 4 to 8 weeks, giving the skin time to heal⁸

Can be used in dogs with concomidant disease or in compination with other commonly used medications, including APOQUEL⁹

Targets and neutralizes interlukin (IL)-31, a key itch-inducing cytokine in allergic and atopic dermatitis¹⁰

Provides long-lasting relief with a single in-office injection, ensuring compliance⁸

CYTOPOINT is a great choice for:

dogs who are difficult to pill or cases in which owner compliance is a concern

dogs with comorbidities

owners who seek non-drug therapy

dogs of all ages

dogs requiring lasting, life-long disease management

When managing an atopic dermatitis patient, remember:

Treat for fleas year-round

Dogs with atopic dermatitis should be treated year-round for fleas^8‡

Remain vigilant for infection

Up to 66 percent of dogs with atopic dermatitis have a concurrent yeast or bacterial skin infection⁹

Exeland's story¹⁰

9-year-old male Labrador Retriever
Atopic dermatitis uncontrolled with antihistamines, glucocorticoids, cyclosporine, allergen-specific immunotherapy and elimination diet
Diagnosed with blastomycosis and treated with systemic antifungals, and secondary bacterial pneumonia and Staph pyoderma treated with systemic antibiotics
Exeland's veterinarian chose CYTOPOINT to manage the atopic dermatitis
2 days after the initial injection, Exeland's owner reported that the itch was 0/10
Exeland's blastomycosis continues improving clinically and he remains free of skin and ear infections

Exeland before CYTOPOINT for his atopic dermatitis

Before Treatment
Staph pyoderma secondary to uncontrolled atopic dermatitis

Exeland after CYTOPOINT for his atopic dermatitis

After Treatment

CYTOPOINT helped protect the bond

Exeland's owner has a debilitating condition that affects his manual dexterity and makes regular pilling challenging, and Exeland's treatments and illness had been both mentally and physically overwhelming for him. For both owner and dog, Exeland's refractory itch had a severe negative impact on quality of life before CYTOPOINT.

Next, Long-term management

Learn more at CYTOPOINT.COM

Learn more at APOQUEL.COM

CYTOPOINT Indications: CYTOPOINT has been shown to be effective for the treatment of dogs against allergic dermatitis and atopic dermatitis.

APOQUEL Indications: Control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.

APOQUEL IMPORTANT SAFETY INFORMATION: Do not use APOQUEL in dogs less than 12 months of age or those with serious infections. APOQUEL may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. APOQUEL has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporine. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. APOQUEL has been used safely with many common medications including parasiticides, antibiotics and vaccines.

For more information, please see the full Prescribing Information.

Repeat administration every 4 to 8 weeks as needed in individual patients.¹

2015 ICADA Guidelines recommend systemic and oral adulticides like SIMPARICA for dogs who are frequently shampooed.

References: 1. Data on file, Study Report No. C863R-US-12-018, Zoetis Inc. 2. Gadeyne C, Little P, King VL, et al. Efficacy of oclacitinib (APOQUEL®) compared with prednisolone for the control of pruritus and clinical signs associated with allergic dermatitis in client-owned dogs in Australia. Vet Dermatol. 2014;25(6):512-518. doi:10.1111/vde.12166. 3. Gonzales AJ, Bowman J, Fici G, et al. Oclacitinib (APOQUEL®) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. J Vet Pharmacol Ther. 2014;37(4):317-324. doi:10.1111/jvp.12101. 4. Cosgrove SB, Cleaver DM, King VL, et al. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. Vet Dermatol. 2015;26(3):171-179. doi:10.1111/vde.12194. 5. Aleo MM, Galvan EA, Fleck JT, et al. Effects of oclacitinib and prednisolone on skin test sensitivity [abstract]. Vet Dermatol. 2013;24(3):297. 6. Data on file, Study Report No. C961R-US-13-051, Zoetis Inc. 7. Gonzales AJ, Humphrey WR, Messamore JE, et al. Interleukin-31: its role in canine pruritus and naturally occurring canine atopic dermatitis. Vet Dermatol. 2013;24(1):48-53. doi:10.1111/j.1365-3164.2012.01098.x. 8. Olivry T, DeBoer D, Favrot C, et al. Treatment of canine atopic dermatitis: 2015 updated guidelines from the International Committee on Allergic Diseases of Animals (ICADA). BMC Vet Res. 2015;11:210. doi:10.1186/s12917-015-0514-6. 9. Bizikova P, Santoro D, Marsella R, et al. 32 of 41 Review: clinical and histological manifestations of canine atopic dermatitis. Vet Dermatol. 2015;26(2):79-e24. 10. Data on file, CYTOPOINT Case Studies, 2015, Zoetis Inc.

Testimonials represent individual experience only and the experiences and opinions herein may be unique to the patient and the speaker. Individual results may vary, considering the unique characteristics of the patient.

The animal health information contained herein is provided for educational purposes only and is not intended to replace discussions with an animal healthcare professional. All decisions regarding the care of a veterinary patient must be made with an animal healthcare professional, considering the unique characteristics of the patient.

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