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ANTIROBE®

(clindamycin hydrochloride)

Concentrates in leukocytes, reaching the site of infection quickly

ANTIROBE® (clindamycin hydrochloride)

ANTIROBE (clindamycin hydrochloride) Capsules (dogs only) and ANTIROBE Aquadrops Liquid (dogs and cats) are indicated for the treatment of infections caused by susceptible strains of designated microorganisms in the following conditions:

Dogs

  • Skin infections (wounds and abscesses) due to coagulase positive staphylococci (Staphylococcus aureus or Staphylococcus intermedius). Deep wounds and abscesses due to Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium necrophorum and Clostridium perfringens.
  • Dental infections due to Staphylococcus aureus, Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium necrophorum and Clostridium perfringens.
  • Osteomyelitis due to Staphylococcus aureus, Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium necrophorum and Clostridium perfringens.

Cats

  • Skin infections (wounds and abscesses) due to Staphylococcus aureus, Staphylococcus intermedius, Streptococcus spp. Deep wounds and infections due to Clostridium perfringens and Bacteroides fragilis.
  • Dental infections due to Staphylococcus aureus, Staphylococcus intermedius, Streptococcus spp., Clostridium perfringens and Bacteroides fragilis.

 

Capsules:
25 mg – bottles of 600
75 mg – bottles of 200
150 mg – bottles of 100

AQUADROPS Liquid:
20 mL filled in 30 mL bottles (25 mg/mL) supplied in packers containing 12 cartoned bottles with direction labels and calibrated dosing droppers.

 

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  • Key Benefits
    • Concentrates in leukocytes, quickly reaching the infection site to treat intracellular pathogens.1
    • Activity against susceptible strains of aerobic and anaerobic bacteria.
    • Maintains full antimicrobial activity in purulent environments.2
    • Penetrates biofilms found in both dental and bone infections.3,4
    • No reconstitution or refrigeration needed.
    • Convenient once-a-day dosing for cats.

     

  • Dosage and Administration



    Please refer to the full Prescribing Information for complete dosage and administration information.

     

  • References

    1. Gemmel CG. Interactions between clindamycin and immune function. Rev Contemp Pharmacother. 1992;3:321-327.

    2. Joiner KA, Lowe BR, Dzink JL, et al. Antibiotic levels in infected and sterile subcutaneous abscesses in mice. J Infect Dis. 1981;143:487-494.

    3. Veringa EM, Ferguson DA, Lambe DW, et al. The role of glycocalyx in surface phagocytosis of Bacteriodes spp. in the presence and absence of clindamycin. J Antimicrob Chemother. 1989;23:711-720.

    4. Zetner K, Pum G, Rausch W-D, et al. Effect of clindamycin hydrochloride on gingival crevicular fluid and immune mediators in beagles. Vet Ther. 2002;3(2):177-188.


IMPORTANT SAFETY INFORMATION:
Do not use ANTIROBE in animals with a history of hypersensitivity to clindamycin or lincomycin.

See full Prescribing Information, attached.

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