Print page content Print
Increase text size Decrease text size
Text Size


(neomycin sulfate; isoflupredone acetate;
tetracaine hydrochloride)

Delivers the therapeutic benefit of a topical antibiotic,
anti-inflammatory, and anesthetic


NEO-PREDEF with Tetracaine Topical Powder is indicated in the treatment or adjunctive therapy of certain ear and skin conditions—in dogs, cats and horses—caused by or associated with neomycin susceptible organisms and/or allergy. In addition, it is indicated as superficial dressing applied to minor cuts, wounds, lacerations and abrasions, and for postsurgical application where reduction of pain and inflammatory response is deemed desirable.

NEO-PREDEF with Tetracaine may be used as a dusting powder following: amputation of tails, claws and dew-claws; ear trimming and castrating; and surgical procedures such as ovariohysterectomies.

Applied superficially, it has been used successfully in the treatment of acute otitis externa, acute moist dermatitis and interdigitial dermatitis in dogs, and as a dusting powder to various minor cuts, lacerations, and abrasions in the horse, cat and dog.

15 gram plastic insufflator bottles (pack of 12).

Collapse All
    • 3-way therapy provides an antibiotic, anti-inflammatory, and anesthetic effect.
      • Isoflupredone has potent anti-inflammatory action.
      • Neomycin has a broad spectrum of antibacterial activity.
      • Tetracaine provides rapid, potent topical anesthesia that can reduce the possibility of self-inflicted trauma.
    • Prompt relief of symptoms.
    • Reduces further self-inflicted trauma.
    • Ease of application.
    • Adherent to moist surfaces.

Prior to administering NEO-PREDEF with Tetracaine, ensure tympanic membrane is not ruptured. If hearing or vestibular dysfunction is noted during the course of treatment discontinue use. Observe treated animals for signs of hypersensitivity or allergy and discontinue use if noted.

See full Prescribing Information.



Mon–Fri, 8:30am–8:00pm ET

This site is intended for U.S. Animal Healthcare Professionals. The product information provided in this site is intended only for residents of the United States. The products discussed herein may not have marketing authorization or may have different product labeling in different countries. The animal health information contained herein is provided for educational purposes only and is not intended to replace discussions with an animal healthcare professional. All decisions regarding the care of a veterinary patient must be made with an animal healthcare professional, considering the unique characteristics of the patient.

All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. ©2021 Zoetis Services LLC. All rights reserved.