United States

REVOLUTION PLUS combines the proven broad-spectrum protection of selamectin with the advanced flea- and tick-killing power of sarolaner

REV UP Protection Inside and Out

REVOLUTION PLUS is a simple-to-apply, quick-drying, small-volume, monthly topical solution that protects against fleas (Ctenocephalides felis), ticks (black-legged or deer tick (Ixodes scapularis), Gulf Coast tick (Amblyomma maculatum) and American dog tick (Dermacentor variabilis)), ear mites (Otodectes cynotis), roundworms (Toxocara cati), hookworms (Ancylostoma tubaeforme), and heartworms (Dirofilaria immitis) for cats and kittens as young as eight weeks of age and weighing 2.8 pounds or greater.

STARTS KILLING FLEAS
WITHIN 6 HOURS
Residual speed of kill maintained through day 28 during subsequent weekly infestations
  • 100% REDUCTION in adult flea count for at least 35 days in TWO clinical trials against an existing infestation and weekly reinfestation
  • INTERRUPTS THE FLEA LIFE CYCLE by killing fleas before they can lay eggs
  • DECREASES SIGNS of flea allergy dermatitis

See the MOAs, or modes of action, behind the "PLUS"

Unique Dual Action

Selamectin and Sarolaner Deliver Even Broader Protection Against Parasites ...
With Unique Dual Action Against Fleas and Ear Mites

  • Selamectin MOA: kills parasites primarily through interference with their glutamate-gated chloride channels, causing paralysis and death of the target parasite
  • Sarolaner MOA: kills parasites primarily through interference with their GABA-gated chloride channels, causing increased nerve stimulation and death of the target parasite
Selamectin and Sarolaner Deliver Even Broader Protection Against ParasitesSelamectin and Sarolaner Deliver Even Broader Protection Against Parasites

Black-legged or Deer Tick
(Ixodes scapularis)

Black-legged or Deer Tick

Photo: James Gathany, Centers for Disease Control and Prevention

Gulf Coast Tick
(Amblyomma maculatum)

Gulf Coast Tick

Photo: Centers for Disease Control and Prevention

American Dog Tick
(Dermacentor variabilis)

American Dog Tick

Photo: James Gathany, Centers for Disease Control and Prevention

Effective results sustained for up to 5 weeks for black-legged or deer tick and American dog tick

Explore tick descriptions and distribution

Black Legged or Deer Tick ranges map
Image by Centers for Disease Control and Prevention

Distribution: Widely distributed across the eastern United States13

Description: Adults ≈ 3 mm long; males dark brown to black in color; females are orange to red behind the scutum14

Parasite ranges are expanding, and the threat is ongoing

Guklf Coast Tick ranges map
Image by Centers for Disease Control and Prevention

Distribution: Coastal areas of the U.S. along the Atlantic coast and the Gulf of Mexico13

Description: ≈ 6 mm long; unfed females have a reduced dark brown scutum with silvery white posterior stripes; unfed males’ scutum covers the entire top of the tick and is dark brown, with interconnected ornamentation of silvery white lines15

Parasite ranges are expanding, and the threat is ongoing

American Dog Tick ranges map
Image by Centers for Disease Control and Prevention

Distribution: Widely distributed east of the Rocky Mountains. Also occurs in limited areas on the Pacific Coast13

Description: Brown to reddish-brown with gray/silver markings on the scutum. Unfed females are ≈ 5 mm long and males are ≈ 3.6 mm long. Females have a short scutum while the male scutum covers the majority of its dorsal surface16

Parasite ranges are expanding, and the threat is ongoing

REVOLUTION ® PLUS

>99% reduction in live counts

Maintains efficacy for 1 month after 1 dose

See the MOAs, or modes of action, behind the "PLUS"

Unique Dual Action

Selamectin and Sarolaner Deliver Even Broader Protection Against Parasites ...
With Unique Dual Action Against Fleas and Ear Mites

  • Selamectin MOA: kills parasites primarily through interference with their glutamate-gated chloride channels, causing paralysis and death of the target parasite
  • Sarolaner MOA: kills parasites primarily through interference with their GABA-gated chloride channels, causing increased nerve stimulation and death of the target parasite
Unique Dual Action

100%

REDUCTION IN ROUNDWORM
(Toxocara cati) fecal egg count on Days 30 and 60 (dosed once monthly)6

99.4%

REDUCTION IN HOOKWORM
(Ancylostoma tubaeforme) fecal egg counts at 30 days and 99.7% at 60 days6

All cats, regardless of their lifestyle, should be on year-round heartworm prevention

— Gary D. Norsworthy, DVM, DABVP (Feline), 2018 AAFP Conference

Every cat and kitten NEEDS heartworm protection

  • According to CAPC, data suggests that cats are infected with juvenile worms at the same rate as dogs8

  • Juvenile worms in cats are capable of causing severe lung damage, known as Heartworm-Associated Respiratory Disease (HARD)8  and sudden death

  • Adult heartworm infections are less common (10% the rate of dogs) but also cause HARD8

Greater than 1 in 4 catsGreater than 1 in 4 cats

Learn about Heartworm-Associated Respiratory Disease (HARD) in cats and kittens

The HARD Facts

Heartworm-Associated Respiratory Disease (HARD) in Cats

  • Over 25% of adult heartworm-infected cats had no signs of infection9
  • However, 10% of infected cats died suddenly without other clinical signs9
  • Signs of respiratory tract disease and vomiting were the most commonly represented clinical signs9