REVOLUTION PLUS Prescribing Information

REVOLUTION® Prescribing Information

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REVOLUTION PLUS is proven safe for cats and kittens as young as 8 weeks of age, weighing 2.8 lbs or greater

BUILDING ON THE TRUSTED LEGACY OF REVOLUTION® (selamectin)

Veterinarians’ #1 Choice for Cats Veterinarians’ #1 Choice for Cats
20 Years of Proven Safety 20 Years of Proven Safety
  • In pre-approval clinical studies, no adverse reactions were associated with the concurrent use of REVOLUTION PLUS and commonly prescribed veterinary products
  • REVOLUTION PLUS may be administered to cats with adult heartworm infection

Adverse Reactions

Adverse Events by Treatment Group

In a field safety and effectiveness study, REVOLUTION PLUS was administered to cats and fleas. The study included a total of 430 cats (282 treated with REVOLUTION PLUS and 148 treated with imidacloprid + moxidectin once monthly for three treatments). Over the 90-day study period, all observations of potential adverse reactions were recorded. Reactions reported in the REVOLUTION PLUS group included those presented in the following table.
Adverse reactionsAdverse reactionsAdverse reactions

IMPORTANT SAFETY INFORMATION:

The safe use of REVOLUTION PLUS has not been established in kittens less than 8 weeks old or in breeding, pregnant or lactating cats. Reported side effects in clinical trials included lethargy and anorexia. Use with caution in cats with a history of neurologic disorders. Sarolaner, one of the ingredients in REVOLUTION PLUS, is a member of the isoxazoline class, which has been associated with adverse reactions such as tremors, ataxia, and seizures. Reactions have occurred in cats with or without a history of neurologic disorders. In humans, REVOLUTION PLUS may be irritating to skin and eyes.

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REVOLUTION PLUS is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. REVOLUTION PLUS kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestations with Ixodes scapularis (black-legged tick), Amblyomma maculatum (Gulf Coast tick) and Dermacentor variabilis (American dog tick), the treatment and control of ear mite (Otodectes cynotis) infestations, and the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections for one month in cats and kittens 8 weeks and older, and weighing 2.8 pounds or greater.

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