Scientific References

United States

SCIENTIFIC REFERENCES

1. VetStreet Data Analytics 2018. Canine and Feline Flea, Tick, Heartworm Market Share. December 2017. Data on file. Zoetis Inc.
2. Vetstreet Data Analytics 2015. Vetstreet % Pets Purchasing FTH. Data on file. Zoetis Inc. 3.
3. Dog owner flea/tick product study: executive summary & data sheet. March 15, 2016. Data on file. Zoetis Inc.
4. Foster Rosenblatt Top Cat Pricing Research & Forecast. Data on file. Zoetis Inc.
5. Indoor Cats Parasiticides Tracker: “Stock Up” survey; fielded on 5/21-6/5/2018. Data on file. Zoetis Inc.
6. Core Technical Slides, 2018. Data on file. Zoetis Inc.
7. Norsworthy GD. HARD facts about heartworms in cats. Presented at: American Association of Feline Practitioners (AAFP) Conference; September 28, 2018; Charlotte, NC, Alamo Feline Health Center, San Antonio, Texas.
8. Companion Animal Parasite Counsel (CAPC), Heartworms; Available at: https:www.capcvet.org/guidelines/heartworms/. Accessed Aug. 21st, 2018
9. Atkins CE, DeFrancesco TC, Coats JR, Sidley JA, Keene BW. Heartworm infection in cats: 50 cases (1985-1997). J Am Vet Med Assoc. 2000;217(3):355-358.
10. Cat Owners – Fleas. Companion Animal Parasite Council. Available at: http://www.petsandparasites.org/cat-owners/fleas/. Accessed September 2018.
11. Fleas – Cat. Companion Animal Parasite Council. Available at: https://www.capcvet.org/guidelines/fleas/. Accessed September 2018.
12. Foil CS. Flea Allergy. Annual Dermatology Conference, Louisiana State University, December 11, 2005. Available at: http://www.lsu.edu/vetmed/veterinary_hospital/services/dermatology/ ce_lectures/flea_allergy.php. Accessed June 2018.
13. Geographic distribution of ticks that bite humans. Available at: https://www.cdc.gov/ticks/geographic_distribution.html. Accessed September 2018.
14. Tick description. Available at: http://entnemdept.ufl.edu/creatures/URBAN/MEDICAL/Deer tick.htm. Accessed September 2018
15. Tick description. Available at: http://entnemdept.ufl.edu/creatures/urban/medical/gulf_coast_tick.htm. Accessed September 2018.
16. Tick description. Available at: http://entnemdept.ufl.edu/creatures/urban/medical/american_dog_tick.htm. Accessed September 2018.
17. Ticks – Cat. Companion Animal Parasite Council. Available at: https://www.capcvet.org/guidelines/ticks/.Accessed September 2018.
18. Cat Owners – Ticks. Companion Animal Parasite Council. Available at: http://www.petsandparasites.org/cat-owners/ticks/. Accessed September 2018.
19. Cat Owners – Ear Mites. Companion Animal Parasite Council. Available at: http://www.petsandparasites.org/cat-owners/ear-mites. Accessed September 2018.
20. Gastrointestinal parasites of cats. Cornell University College of Veterinary Medicine. Available at: http://www.vet.cornell.edu/fhc%20/Health_Information /brochure_parasite.cfm. Accessed June 2018.
21. Cat Owners – Roundworms. Companion Animal Parasite Council. Available at: http://www.petsandparasites.org/cat-owners/roundworms/. Accessed September 2018.
22. Cat Owners – Hookworms. Companion Animal Parasite Council. Available at: http://www.petsandparasites.org/cat-owners/hookworms/. Accessed September 2018.
23. Cat Owners – Heartworms. Companion Animal Parasite Council. Available at: http://www.petsandparasites.org/cat-owners/heartworms/. Accessed September 2018.
24. REVOLUTION® [package insert]. Kalamazoo, MI: Zoetis Inc; 2018.
25. Advantage Multi [package insert]. Shawne Mission, KS: Bayer Animal Health; 2016.
26. Frontline Gold brochure. Your golden opportunity awaits; 2017. Merial, Inc. Duluth, GA; 2017.
27. Bravecto Topical Solution for Dogs [prescribing information]. Madison, NJ. Merck Animal Health; 2016.

IMPORTANT SAFETY INFORMATION:

The safe use of REVOLUTION PLUS has not been established in kittens less than 8 weeks old or in breeding, pregnant or lactating cats. Reported side effects in clinical trials included lethargy and anorexia. Use with caution in cats with a history of neurologic disorders. Sarolaner, one of the ingredients in REVOLUTION PLUS, is a member of the isoxazoline class, which has been associated with adverse reactions such as tremors, ataxia, and seizures. Reactions have occurred in cats with or without a history of neurologic disorders. In humans, REVOLUTION PLUS may be irritating to skin and eyes.

PRESCRIBING INFORMATION >>

REVOLUTION PLUS is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. REVOLUTION PLUS kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestations with Ixodes scapularis (black-legged tick), Amblyomma maculatum (Gulf Coast tick) and Dermacentor variabilis (American dog tick), the treatment and control of ear mite (Otodectes cynotis) infestations, and the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections for one month in cats and kittens 8 weeks and older, and weighing 2.8 pounds or greater.

SCIENTIFIC REFERENCES >>

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