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SIMBADOL buprenorphine injection

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i Giordano T, Steagall PVM, Ferreira TH, et al Postoperative analgesic effects of intravenous, intramuscular, subcutaneous or oral transmucosal buprenorphine administered to cats undergoing ovariohysterectomy. Vet A & A. 2010:37:357-366.
ii Polson S, Taylor PM, Yates D. Analgesia after feline ovariohysterectomy under midazolam-medetomidine-ketamine anaesthesia with buprenorphine or butorphanol and carprofen or meloxicam: a prospective randomised clinical trial. J Fel Med & Surg 2012, 14: 553-559.
iii Santos LC, Ludders JW, Erb HN et al. Sedative and cardiorespiratory effects of dexmedetomidine and buprenorphine administered to cats via oral transmucosal or intramuscular routes. Vet A & A 2010, 37: 417-424.
iv Porters N, Bosmans T, Debille, et al.  Sedative and antinociceptive effects of dexmedetomidine and buprenorphine after oral transmucosal or intramuscular administration in cats. Vet A & A, 2014: 41: 90-96.
v Staffieri F, Centonze P, Gigante G et al. Comparison of the analgesic effects of robenacoxib, buprenorphine and their combination in cats after ovariohysterectomy. The Vet J, 2013, 197: 363-367.
vi Warne LN, Beths T, Holm M, et al. Evaluation of the perioperative analgesic efficacy of buprenorphine compared with butorphanol in cats. JAVMA, 2014; 245: 195-202.
vii Catbagan DL, Quimby JM, Mama KR, et al. Comparison of the efficacy and adverse effects of sustained-release buprenorphine hydrochloride following subcutaneous administration and buprenorphine hydrochloride following oral transmucosal administration in cats undergoing ovariohysterectomy. AJVR, 2011; 72: 461-466.
viii Steagall PVM, Monteiro-Steagall BP, Taylor PM. A review of the studies using buprenorphine in cats. J Vet Intern Med, 2010; 2014:762-770.
ix Brewster D, Humphrey MJ, McLeavy MA. Biliary excretion, metabolism and enterohepatic circulation of buprenorphine. Xenobiotica 1981;11:189-196.
x Court MH. Feline drug metabolism and disposition: pharmacokinetic evidence for species differences and molecular mechanisms. Vet Clin Small Anim 2013; 43:1039-1054.
xi Zoetis Study Report: Summary Report for In-Use Stability Study for Multi-Dose Buprenorphine Injection, 1.8 mg/mL. November 14, 2012. (10 mL Presentation)AAI Pharma

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24-hour. The only FDA Approved buprenorphine for cats.
ONE INJECTION ADMINISTERED IN-CLINIC
24 HOURS OF CONTINUOUS PAIN CONTROL
UP TO 3 ONCE-DAILY SUBCUTANEOUS DOSES FOR A TOTAL OF 72 HOURS OF PAIN CONTROL1
DEMONSTRATED SAFETY AND EFFICACY IN MORE THAN 200 CATS TREATED WITH SIMBADOL1
COST COMPETITIVE
100% COMPLIANCE
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INDICATION: SIMBADOL is indicated for the control of postoperative pain associated with surgical procedures in cats.

See References for detailed information about research studies referenced on this website.

IMPORTANT SAFETY INFORMATION: Due to serious human safety and abuse concerns, including physical or psychological dependence, life-threatening respiratory depression and additive CNS depressant effects, read the full prescribing information before using this drug, including the complete Boxed Warning. Not for use in humans. Hospital staff should be trained in the handling of potent opioids and should avoid accidental exposure. SIMBADOL has not been evaluated in breeding, pregnant, or lactating cats, in cats younger than 4 months of age or moribund cats. Do not use in cats with known hypersensitivity to buprenorphine hydrochloride or any of the components of SIMBADOL, or known intolerance to opioids. Use with caution in cats with impaired hepatic function. Adverse reactions may include hyperthermia, tachycardia, hypotension, hypertension, hypothermia, anorexia, and hyperactivity. For more safety information, refer to the full Prescribing Information.

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