- SIMBADOL (package insert), Florham Park, NJ, Zoetis, 2014.
- Data on file. Clinical Efficacy (Soft Tissue), 08-30-MC-D-CT-BP, and Clinical Efficacy (Orthopedic), 08-31-MC-D-CT-BP. Zoetis.
- Hellyer PW, Uhrig SR, Robinson NG. Colorado State University Veterinary Medical Center feline acute pain scale. 2006.
- Brondani, JT, Luna SP, Padovani CR. Refinement and initial validation of a multidimensional composite scale for use in assessing acute postoperative pain in cats. Am J Vet Res. 2011;72(2):174-183.
- Calvo G, Holden E, Reid J, et al. Development of a behaviour-based measurement tool with defined intervention level for assessing acute pain in cats. J Small Anim Pract. 2014;55(12):622-629.
- Freedom of Information Summary, NADA 141-434, SIMBADOL, July 18, 2014.
- Grim K, Tranquilli W, Lamont L, eds. Essentials of Small Animal Anesthesia and Analgesia. 2nd ed. Hoboken, NJ: Wiley-Blackwell; 2011:99.
- Heel RC, Brogden RN, Speight TM, et al. Buprenorphine: a review of its pharmacological properties and therapeutic efficacy. Drugs. 1979;17(2):81-110.
- Steagall PV, Pelligand L, Giordano T, et al. Pharmacokinetic and pharmacodynamic modelling of intravenous, intramuscular and subcutaneous buprenorphine in conscious cats. Vet Anaesth Analg. 2013;40(1):83-95.
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ii Polson S, Taylor PM, Yates D. Analgesia after feline ovariohysterectomy under midazolam-medetomidine-ketamine anaesthesia with buprenorphine or butorphanol and carprofen or meloxicam: a prospective randomised clinical trial. J Fel Med & Surg 2012, 14: 553-559.
iii Santos LC, Ludders JW, Erb HN et al. Sedative and cardiorespiratory effects of dexmedetomidine and buprenorphine administered to cats via oral transmucosal or intramuscular routes. Vet A & A 2010, 37: 417-424.
iv Porters N, Bosmans T, Debille, et al. Sedative and antinociceptive effects of dexmedetomidine and buprenorphine after oral transmucosal or intramuscular administration in cats. Vet A & A, 2014: 41: 90-96.
v Staffieri F, Centonze P, Gigante G et al. Comparison of the analgesic effects of robenacoxib, buprenorphine and their combination in cats after ovariohysterectomy. The Vet J, 2013, 197: 363-367.
vi Warne LN, Beths T, Holm M, et al. Evaluation of the perioperative analgesic efficacy of buprenorphine compared with butorphanol in cats. JAVMA, 2014; 245: 195-202.
vii Catbagan DL, Quimby JM, Mama KR, et al. Comparison of the efficacy and adverse effects of sustained-release buprenorphine hydrochloride following subcutaneous administration and buprenorphine hydrochloride following oral transmucosal administration in cats undergoing ovariohysterectomy. AJVR, 2011; 72: 461-466.
viii Steagall PVM, Monteiro-Steagall BP, Taylor PM. A review of the studies using buprenorphine in cats. J Vet Intern Med, 2010; 2014:762-770.
ix Brewster D, Humphrey MJ, McLeavy MA. Biliary excretion, metabolism and enterohepatic circulation of buprenorphine. Xenobiotica 1981;11:189-196.
x Court MH. Feline drug metabolism and disposition: pharmacokinetic evidence for species differences and molecular mechanisms. Vet Clin Small Anim 2013; 43:1039-1054.
xi Zoetis Study Report: Summary Report for In-Use Stability Study for Multi-Dose Buprenorphine Injection, 1.8 mg/mL. November 14, 2012. (10 mL Presentation)AAI Pharma
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INDICATION: SIMBADOL is indicated for the control of postoperative pain associated with surgical procedures in cats.
See References for detailed information about research studies referenced on this website.
IMPORTANT SAFETY INFORMATION: Due to serious human safety and abuse concerns, including physical or psychological dependence, life-threatening respiratory depression and additive CNS depressant effects, read the full prescribing information before using this drug, including the complete Boxed Warning. Not for use in humans. Hospital staff should be trained in the handling of potent opioids and should avoid accidental exposure. SIMBADOL has not been evaluated in breeding, pregnant, or lactating cats, in cats younger than 4 months of age or moribund cats. Do not use in cats with known hypersensitivity to buprenorphine hydrochloride or any of the components of SIMBADOL, or known intolerance to opioids. Use with caution in cats with impaired hepatic function. Adverse reactions may include hyperthermia, tachycardia, hypotension, hypertension, hypothermia, anorexia, and hyperactivity. For more safety information, refer to the full Prescribing Information.
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