- SIMBADOL (package insert), Florham Park, NJ, Zoetis, 2014.
- Data on file. Clinical Efficacy (Soft Tissue), 08-30-MC-D-CT-BP, and Clinical Efficacy (Orthopedic), 08-31-MC-D-CT-BP. Zoetis.
- Hellyer PW, Uhrig SR, Robinson NG. Colorado State University Veterinary Medical Center feline acute pain scale. 2006.
- Brondani, JT, Luna SP, Padovani CR. Refinement and initial validation of a multidimensional composite scale for use in assessing acute postoperative pain in cats. Am J Vet Res. 2011;72(2):174-183.
- Calvo G, Holden E, Reid J, et al. Development of a behaviour-based measurement tool with defined intervention level for assessing acute pain in cats. J Small Anim Pract. 2014;55(12):622-629.
- Freedom of Information Summary, NADA 141-434, SIMBADOL, July 18, 2014.
- Grim K, Tranquilli W, Lamont L, eds. Essentials of Small Animal Anesthesia and Analgesia. 2nd ed. Hoboken, NJ: Wiley-Blackwell; 2011:99.
- Heel RC, Brogden RN, Speight TM, et al. Buprenorphine: a review of its pharmacological properties and therapeutic efficacy. Drugs. 1979;17(2):81-110.
- Steagall PV, Pelligand L, Giordano T, et al. Pharmacokinetic and pharmacodynamic modelling of intravenous, intramuscular and subcutaneous buprenorphine in conscious cats. Vet Anaesth Analg. 2013;40(1):83-95.
ACUTE FELINE PAIN
Assessing pain in cats is challenging because they are known for hiding pain as a survival instinct. As a result, feline pain is often underdiagnosed.
Subtle behavioral and physiological changes are often the only indicators of feline pain.
changes in facial expression
Feline Acute Pain Scales
There are now two pain scales validated to assess surgical pain in the cat, the UNESP-Botucatu Multidimensional Composite Pain Scale and the Glasgow Composite Measure Pain Scale–Feline.4,5 The Colorado State University Feline Acute Pain Scale is also a useful tool to assess pain in cats, although it has not been validated.3 Regardless of how you are assessing feline postoperative pain, we can assume that cats will feel pain.
Pain processing is similar in all mammals.
It follows four distinct steps.
Assessing and alleviating pain in cats is not only a core goal of veterinary medicine, but successfully controlling the pain of a surgical procedure can also strengthen the human-animal bond and even help reinforce the relationship between veterinarian, client and patient.
Veterinarians tend to agree that feline pain can last longer than 24 hours after common surgical procedures.3 SIMBADOL (buprenorphine injection) is the first and only FDA-approved opioidto provide once-daily 24-hour control of postoperative pain in cats. SIMBADOL works well with other induction and maintenance anesthesia drugs and can be incorporated into any feline surgical protocols.
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INDICATION: SIMBADOL is indicated for the control of postoperative pain associated with surgical procedures in cats.
See References for detailed information about research studies referenced on this website.
IMPORTANT SAFETY INFORMATION: Due to serious human safety and abuse concerns, including physical or psychological dependence, life-threatening respiratory depression and additive CNS depressant effects, read the full prescribing information before using this drug, including the complete Boxed Warning. Not for use in humans. Hospital staff should be trained in the handling of potent opioids and should avoid accidental exposure. SIMBADOL has not been evaluated in breeding, pregnant, or lactating cats, in cats younger than 4 months of age or moribund cats. Do not use in cats with known hypersensitivity to buprenorphine hydrochloride or any of the components of SIMBADOL, or known intolerance to opioids. Use with caution in cats with impaired hepatic function. Adverse reactions may include hyperthermia, tachycardia, hypotension, hypertension, hypothermia, anorexia, and hyperactivity. For more safety information, refer to the full Prescribing Information.
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