- SIMBADOL (package insert), Florham Park, NJ, Zoetis, 2014.
- Data on file. Clinical Efficacy (Soft Tissue), 08-30-MC-D-CT-BP, and Clinical Efficacy (Orthopedic), 08-31-MC-D-CT-BP. Zoetis.
- Hellyer PW, Uhrig SR, Robinson NG. Colorado State University Veterinary Medical Center feline acute pain scale. 2006.
- Brondani, JT, Luna SP, Padovani CR. Refinement and initial validation of a multidimensional composite scale for use in assessing acute postoperative pain in cats. Am J Vet Res. 2011;72(2):174-183.
- Calvo G, Holden E, Reid J, et al. Development of a behaviour-based measurement tool with defined intervention level for assessing acute pain in cats. J Small Anim Pract. 2014;55(12):622-629.
- Freedom of Information Summary, NADA 141-434, SIMBADOL, July 18, 2014.
- Grimm K, Tranquilli W, Lamont L, eds. Essentials of Small Animal Anesthesia and Analgesia. 2nd ed. Hoboken, NJ: Wiley-Blackwell; 2011:99.
- Heel RC, Brogden RN, Speight TM, et al. Buprenorphine: a review of its pharmacological properties and therapeutic efficacy. Drugs. 1979;17(2):81-110.
- Steagall PV, Pelligand L, Giordano T, et al. Pharmacokinetic and pharmacodynamic modelling of intravenous, intramuscular and subcutaneous buprenorphine in conscious cats. Vet Anaesth Analg. 2013;40(1):83-95.
ONCE-DAILY* 24‑HOUR CONTINUOUS SURGICAL PAIN CONTROL FOR CATSORDER SIMBADOL
See full Prescribing Information, including the complete Boxed Warning for human safety.
In two large clinical studies, SIMBADOL
(buprenorphine injection) was well
tolerated and demonstrated safety and
efficacy for postoperative pain control
INJECTION ONCE DAILY
SIMBADOL administered subcutaneously once daily on days one (60 minutes before surgery), two and three.1
TREATMENT SUCCESS FOR
SIMBADOL TREATED CATS
Successful treatment defined as a cat not requiring rescue analgesia during the 72-hour observation period.
In Soft Tissue Surgery and Orthopedic Surgery studies, the majority of adverse events were mild in severity and either typical opioid reactions or were similar to the placebo group in frequency.3,4
PAIN MANAGEMENT FOR CATS
With one dose, your feline patients get 24 hours of continuous postoperative pain control, while saving your staff the time and effort of multiple injections.
24 HOURS OF CONTINUOUS
PAIN CONTROL FOR CATS
SIMBADOL lasts as long as three or four doses of other feline pain medications
INDICATION: SIMBADOL is indicated for the control of postoperative pain associated with surgical procedures in cats.
See References for detailed information about research studies referenced on this website.
IMPORTANT SAFETY INFORMATION: Due to serious human safety and abuse concerns, including physical or psychological dependence, life-threatening respiratory depression and additive CNS depressant effects, read the full prescribing information before using this drug, including the complete Boxed Warning. Not for use in humans. Hospital staff should be trained in the handling of potent opioids and should avoid accidental exposure. SIMBADOL has not been evaluated in breeding, pregnant, or lactating cats, in cats younger than 4 months of age or moribund cats. Do not use in cats with known hypersensitivity to buprenorphine hydrochloride or any of the components of SIMBADOL, or known intolerance to opioids. Use with caution in cats with impaired hepatic function. Adverse reactions may include hyperthermia, tachycardia, hypotension, hypertension, hypothermia, anorexia, and hyperactivity. For more safety information, refer to the full Prescribing Information.
All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted.
Zoetis Services LLC. All rights reserved. SIM-00052
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