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SIMBADOL buprenorphine injection
24-hour continuous surgical pain control for cats

THE SCIENCE
BEHIND SIMBADOL

SIMBADOL is a novel combination of dose and concentration. It contains 1.8 mg/mL of buprenorphine hydrochloride and has been specifically formulated so that one dose of 0.24 mg/kg administered subcutaneously (SQ) will provide 24 hours of continuous postoperative analgesia to a cat. Watch the Mechanism of Action video below to see exactly how SIMBADOL works to block pain in cats following surgery.

Watch vets explain the use and benefits of SIMBADOL.


SIMBADOL is an immediate-release product, so buprenorphine is quickly absorbed after SQ injection. It begins to take effect within one hour after administration.

SIMBADOL mechanism of action
SIMBADOL onset of analgesia

Pharmacokinetics and Pharmacodynamics

How effective a pain medication is, and how long that pain control lasts, often depends on how closely the drug binds with a receptor. Buprenorphine has both high affinity and high avidity for the opioid receptors8, making it a highly effective pain medication for feline pain relief.

Most formulations of buprenorphine only provide 6 to 8 hours of analgesia. In order to achieve 24 hours of continuous feline pain control, multiple doses are required. Depending on the dosage and dosing interval, cats may experience pain between doses.

SIMBADOL is unique in that it provides continuous analgesia for a full 24 hours with only one injection. The longer duration of analgesia associated with SIMBADOL is likely related to a combination of dosage, metabolism and receptor affinity and avidity.

How SIMBADOL works to control pain

SIMBADOL pain pathway SIMBADOL pain pathway
1
Transmission
SIMBADOL may have an analgesic effect on peripheral nerves.
2
Modulation
The impulses are inhibited or blocked by SIMBADOL acting on the mu receptors in the dorsal horn.
3
Perception
SIMBADOL blocks pain from being recognized in the brain for 24 hours by binding to the mu receptors.

Why SIMBADOL is the Best Choice for Postsurgical Feline Pain Control

24-hour duration of activity

Every cat responds differently to buprenorphine.9 However, in two large field studies, one dose of SIMBADOL was found to be effective in controlling postoperative pain associated with surgical procedures in cats for 24 hours.6

Formulated specifically for cats

SIMBADOL is one of very few analgesics that have been formally tested and FDA approved to provide postsurgical pain relief for cats.

Binds selectively

SIMBADOL is a partial mu agonist with a high affinity and avidity, which allows for a prolonged duration of analgesia.

Provides efficacy while ensuring safety

In studies, the majority of adverse effects cited with SIMBADOL were mild in severity and either an expected opioid response (mydriasis, hyperactivity, hyperthermia) or similar to the placebo (hypothermia, anorexia, hypotension).2

Ensures absorption and delivery

SIMBADOL is administered by veterinary staff, so 100% compliance is guaranteed. With SIMBADOL, you know your feline patients will return home with pain treatment “on board.”

Learn more about the safety and efficacy of SIMBADOL
LEARN MORE
Try SIMBADOL Today

Try SIMBADOL Today

24-hour. The only FDA Approved buprenorphine for cats.
ONE INJECTION ADMINISTERED IN-CLINIC
24 HOURS OF CONTINUOUS PAIN CONTROL
UP TO 3 ONCE-DAILY SUBCUTANEOUS DOSES FOR A TOTAL OF 72 HOURS OF PAIN CONTROL1
DEMONSTRATED SAFETY AND EFFICACY IN MORE THAN 200 CATS TREATED WITH SIMBADOL1
COST COMPETITIVE
100% COMPLIANCE
ORDER SIMBADOL

Have Questions?

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INDICATION: SIMBADOL is indicated for the control of postoperative pain associated with surgical procedures in cats.

See References for detailed information about research studies referenced on this website.

IMPORTANT SAFETY INFORMATION: Due to serious human safety and abuse concerns, including physical or psychological dependence, life-threatening respiratory depression and additive CNS depressant effects, read the full prescribing information before using this drug, including the complete Boxed Warning. Not for use in humans. Hospital staff should be trained in the handling of potent opioids and should avoid accidental exposure. SIMBADOL has not been evaluated in breeding, pregnant, or lactating cats, in cats younger than 4 months of age or moribund cats. Do not use in cats with known hypersensitivity to buprenorphine hydrochloride or any of the components of SIMBADOL, or known intolerance to opioids. Use with caution in cats with impaired hepatic function. Adverse reactions may include hyperthermia, tachycardia, hypotension, hypertension, hypothermia, anorexia, and hyperactivity. For more safety information, refer to the full Prescribing Information.

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