LUTALYSE^®

Most-used prostaglandin in the market

LUTALYSE^® Injection (dinoprost tromethamine injection) is the most "veterinarian recommended" and "producer used" prostaglandin in the market.¹ Artificial insemination synchronization programs with LUTALYSE can improve breeding success. Producers and veterinarians today have more options for using LUTALYSE in reproduction programs than ever before. FACTREL^® Injection (gonadorelin injection) is now approved for use with LUTALYSE to synchronize estrous cycles to allow for fixed-time artificial insemination (FTAI) in lactating dairy cows.

LUTALYSE is the only prostaglandin approved to be used with EAZI-BREED™ CIDR^® Cattle Inserts in dairy heifers and dairy cows.

Zoetis is the world leader in dairy reproduction research and support and its products are supported by industry-leading sales and technical services.

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Key Benefits
Use with FACTREL for estrous synchronization is consistent with protocols recommended by the Dairy Cattle Reproduction Council

A synchronized breeding program with LUTALYSE can:

Improve pregnancy rates

Reduce time necessary for heat detection

Make more efficient use of labor

Reduce cull rates

An entirely natural prostaglandin

No meat or milk withdrawal

A product you can trust for performance and safety: LUTALYSE is the most thoroughly researched prostaglandin in the world2

Useful therapeutically for controlled breeding

Ideal dose size reduces problems if injection-site leakage occurs

Dosing & Administration

Effective in animals having a functional corpus luteum in the following applications:

In lactating dairy cows, for use with FACTREL for estrous synchronization to allow for FTAI with the following framework:

	Example 1	Example 2	Example 3
Day 0 (Monday)	1^st FACTREL	1^st FACTREL	1^st FACTREL
Day 7 (the following Monday)	LUTALYSE (25 mg)	LUTALYSE (25 mg)	LUTALYSE (25 mg)
Day 9 (Wednesday)	2^nd FACTREL + FTAI at 48 hours after LUTALYSE	2^nd FACTREL 48 hours after LUTALYSE	2^nd FACTREL 56 hours after LUTALYSE
Day 10 (Thursday)		FTAI 24 hours after 2^nd FACTREL	FTAI 16 hours after FACTREL

For estrus synchronization, inject 5 mL LUTALYSE intramuscularly (IM) either once or twice at 10- to 12-day intervals.
For treatment of unobserved estrus, inject a 5 mL dose IM. If estrus has not been observed by 80 hours after injection, breed at 80 hours; if the cow returns to estrus, breed at the usual time relative to estrus.
For postpartum treatment of pyometra, inject a dose of 5 mL IM at signs of pyometra (presence of a corpus luteum on the ovary and uterine horns containing fluid but not a conceptus based on palpation).

Resources & Technical Information

¹Animalytix Ruminant Segments & Equine MAT ending Jan 2015.

² Based on a literature search of the Journal of Animal Science, Journal of Dairy Science and Theriogenology, 1994-2011.

Presentation: FTAI Research Summary

IMPORTANT SAFETY INFORMATION FOR LUTALYSE: Women of childbearing age and persons with respiratory problems should exercise extreme caution when handling LUTALYSE. LUTALYSE is readily absorbed through the skin and may cause abortion and/or bronchiospasms, therefore spillage on the skin should be washed off immediately with soap and water. Aseptic technique should be used to reduce the possibility of post-injection clostridial infections. Do not administer LUTALYSE in pregnant cattle unless cessation of pregnancy is desired. See full Prescribing Information.

IMPORTANT SAFETY INFORMATION FOR FACTREL: FACTREL is for use in cattle only. See full Prescribing Information.

IMPORTANT SAFETY INFORMATION FOR EAZI-BREED CIDR: Avoid contact with skin by wearing protective gloves when handling EAZI-BREED CIDR inserts. Do not use in heifers of insufficient size or age for breeding or in cattle with abnormal, immature, or infected genital tracts. Do not use inserts more than once.