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Orbeseal®

Prevent New Infections, Naturally™

Orbeseal® is a sterile, non-antibiotic intramammary infusion in the form of a viscous paste. Orbeseal is indicated for the prevention of new intramammary infections throughout the dry period.

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  • Orbeseal Works

    The effectiveness of Orbeseal is well-researched. In a trial1 completed by the University of Minnesota in well-managed, high-producing herds using a mastitis vaccination program, infusing Orbeseal following dry-cow therapy was evaluated against conventional dry-cow therapy alone.

    The results showed statistical significance in favor of the Orbeseal-treated group by improving all three key economic parameters as follows:

    • 20% improvement in incidence of new infections at calving
    • 26% improvement in clinical mastitis between dry-off and 60 days in milk
    • 19% improvement* in somatic cell count at 6–8 days in milk

    Imagine what this can mean to your operation.

    *Somatic cell count data derived from linear scores.

    Key Features

    • Mimics the cow’s natural first line of defense, the keratin plug.
    • Provides a safe, antibiotic free, physical barrier between the udder and the environment.
    • Helps control mastitis during the dry period where more than 50% of early lactation Escherichia coli mastitis cases begin.
    • Compatible with conventional dry cow management practices.

    References

    Godden, S., P. Rapnicki, et al. (2003). "Effectiveness of an Internal Teat Seal in the Prevention of New Intramammary Infections During the Dry and Early-Lactation Periods in Dairy Cows when used with a Dry Cow Intramammary Antibiotic." J. Dairy Sci. 86(12): 3899-3911.

  • AFTER USING YOUR CURRENT DRY-COW TREATMENT PROGRAM, PERFORM THE FOLLOWING STEPS:

    For a PDF version with how-to-administer photos, please click here.

    1. Teats should be clean and dry. If teats are not clean, CAREFULLY wash and dry them before disinfection.
    2. Using an alcohol pad, physically clean the end of the teat to remove any contaminated skin, dirt or manure. Repeat until the pad remains clean.
    3. Disinfect the far teats before the near teats to avoid accidental contamination of previously disinfected teats.
    4. Insert the Orbeseal syringe nozzle into the teat canal, grasp the base of the teat near the udder attachment with two fingers press firmly together and slowly inject all contents. Use one complete syringe per quarter. Do not massage. Orbeseal must remain in the teat to be effective.
    5. Insert Orbeseal into the nearest teats first, to minimize contamination of teats that have not been treated.
    6. After inserting Orbeseal, mark the cow so others can tell she has been dried off. Then dip each teat with a quality teat dip.

    Orbeseal requires no milk or preslaughter withdrawal. Follow the withdrawal rules described on the label, when Orbeseal is used in conjunction with a dry-cow treatment program.

    TO REMOVE ORBESEAL, PERFORM THE FOLLOWING STEPS:

     

    1. To effectively strip Orbeseal, be sure to grab the top of the teat-where it meets the udder-and work all the way down. Don’t grab the middle of the teat, squeeze and work down. This will only clear the bottom half of the teat. Strip the entire quarter by starting at the top and working all the way down.
    2. Strip aggressively-10 to 12 times per quarter-for the first 4 days post-freshening. This helps to ensure that you're removing the plug and all Orbeseal particles. Do not remove Orbeseal by action of the milking machine.
    3. Milk into a bucket for the first 3 to 4 days post-freshening. This will help to remove any remaining Orbeseal particles.

    Packaging

    Primary packaging for Orbeseal is a ready-to-use polyethylene intramammary syringe filled with 4 g of the teat sealant infusion. The product is supplied in plastic buckets containing 144 of the intramammary syringes.
     

  • What is Orbeseal®?
    Orbeseal is the first-and-only product of its kind. It is an antibiotic-free paste that acts as a physical barrier against mastitis-causing bacteria, locking them out for the entire dry period. When it is infused at dry off, new mastitis infections can be significantly reduced and somatic cell counts can be lowered.

    Is Orbeseal an antibiotic?
    No, Orbeseal does not contain any antibiotics and, therefore, will not treat any subclinical or clinical mastitis infections that may be present at dry off.

    Does the keratin plug seal all teat ends adequately and fast enough after dry off?
    No, many teat ends remain open, leaving cows more susceptible to new infections during the dry period. A recent North American study demonstrated that nearly half of all teats remained open during the first week of dry off, while over 23 percent of teats remained open six weeks after dry off.1

    How does Orbeseal work?
    Infusing a single Orbeseal tube into each teat at dry off mimics the function of the cow’s natural keratin plug by instantly sealing all teats for the entire dry period.

    For what period of time does Orbeseal work?
    X-ray images have shown that Orbeseal-treated teat ends will remain sealed
    for at least 100 days, or until Orbeseal is stripped out at calving.

    I am already using a dry cow antibiotic and a mastitis vaccine in my dry cow treatment program. Why should I add Orbeseal?
    Research has shown that cows treated with Orbeseal and a dry cow treatment program* had a significant reduction of clinical mastitis, even in a well-managed dry cow environment, when compared to a conventional dry cow treatment program alone.2 Results showed statistical significance in favor of the Orbeseal-treated
    group, which exhibited improvement in three economic parameters:

    • 20% improvement in incidence of new infections at calving.
    • 26% improvement in clinical mastitis between dry off and 60 days in milk.
    • 19% improvement** in somatic cell count at 6-8 days in milk.

    What are the important steps that should be taken to ensure fast and effective sealing of teat ends?
    Each teat should be cleaned and disinfected prior to the infusion of any product. Orbeseal is a sterile product, but the syringe tip easily can be contaminated with bacteria if aseptic techniques are not used. DO NOT MASSAGE THE UDDER after infusing Orbeseal.

    Do I have to strip Orbeseal out by hand before applying the milking machine after calving?
    Stripping Orbeseal out by hand is the best option. The removal of Orbeseal by the milking machine should not be done.

    Is Orbeseal safe?
    Each tube contains bismuth subnitrate (65% w/w) in an oil base, which is safe for use in non-lactating dairy cows.

    Does Orbeseal have a withdrawal period?
    Orbeseal alone requires no milk or preslaughter withdrawal. When Orbeseal is used in conjunction with a dry cow antibiotic, withdrawal on the antibiotic label should be followed.

    *Dry cow treatment program includes a dry cow antibiotic and a mastitis vaccine.
    **Somatic cell counts derived from linear score.

    1Dingwell, R.T., Timms, L.L., Sargeant, J.M., Kelton, D.F., Schukken, Y.H. and Leslie, K.E. (2003). The association of teat canal closure and other risk factors for new dry period
    intramammary infections. National Mastitis Council 42nd Annual Meeting Proceedings, 298-299.

    2Godden, S., P. Rapnicki, et al. (2003). "Effectiveness of an Internal Teat Seal in the Prevention of New Intramammary Infections During the Dry and Early-Lactation Periods in Dairy Cows when used with a Dry Cow Intramammary Antibiotic." J. Dairy Sci. 86(12): 3899-3911.

    Orbeseal® is a registered trademark and Prevent New Infections, Naturally™ is a trademark of Zoetis Inc.
    ©2003 Zoetis Inc ORB03019