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When it comes to fast relief from allergic itch without the common side effects of steroids*
IT WOULD
BE A SHAME
TO MAKE
THEM WAIT
When it comes to fast relief from allergic itch without the common side effects of steroids*
IT WOULD
BE A SHAME
TO MAKE
THEM WAIT

FIRST TIME, EVERY TIME

Start and stay with APOQUEL for relief of short- and long-term allergic itch.2,3

Fast and effective

APOQUEL is the first choice of veterinarians for fast allergic itch relief4,5

Effective in flea allergy, food allergy, contact allergy, atopic dermatitis2,6

Proven efficacy for allergic skin diseases

APOQUEL delivered fast relief that began to control itch within 4 hours, comparable to oral steroids, in dogs with allergic dermatitis5,7

Apoquel delivered fast relief vs steroids

*The dose of prednisolone was lowered at Day 6 to account for the real-world dosing scenario of prednisolone.

In a study, APOQUEL exhibited faster onset of relief than AtopicaTM (cyclosporine capsules, USP) in the control of pruritus in dogs with atopic dermatitis8,9

Apoquel delivered fast relief vs Atopica

IMPORTANT SAFETY INFORMATION
Do not use APOQUEL® (oclacitinib tablet) in dogs less than 12 months of age or those with serious infections. APOQUEL may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. APOQUEL has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporine. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. APOQUEL has been used safely with many common medications including parasiticides, antibiotics and vaccines.

For more information, please see the full Prescribing Information.

*Common side effects of steroids include polyuria, polydipsia and polyphagia.12,13 Side effects of APOQUEL reported most often are vomiting and diarrhea.1

References: 1. Data on file, Monthly VetStreet Report, December 2018, Zoetis Inc. 2. Cosgrove SB, Wren JA, Cleaver DM, et al. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. Vet Dermatol. 2013;24(5):479-e114. doi:10.1111/vde.12047. 3. Cosgrove SB, Cleaver DM, King VL, et al. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. Vet Dermatol. 2015;26(3):171-179. doi:10.1111/vde.12194. 4. Data on file, APOQUEL/CYTOPOINT Vet Tracker Wave 11, 2018, Zoetis Inc. 5. Gadeyne C, Little P, King VL, et al. Efficacy of oclacitinib (APOQUEL®) compared with prednisolone for the control of pruritus and clinical signs associated with allergic dermatitis in client-owned dogs in Australia. Vet Dermatol. 2014;25(6):512-e86. doi:10.1111/vde.12166. 6. Moriello KA. Canine allergic dermatitis: pathogenesis, clinical signs, and diagnosis. http://veterinarymedicine.dvm360.com/canine-allergic-dermatitis-pathogenesis-clinical-signs-and-diagnosis. Accessed August 22, 2017. 7. Data on file, Study Report No. A161R-AU-12-096, Zoetis Inc. 8. Little PR, King VL, Davis KR, et al. A blinded, randomized clinical trial comparing the efficacy and safety of oclacitinib and ciclosporin for the control of atopic dermatitis in client-owned dogs. Vet Dermatol. 2015;26(1):23-e8. doi:10.1111/vde.12186. 9. Data on file, Study Report No. 6962R-14-10-025, Zoetis Inc. 10. Data on file, Study Report No. 1962C-60-10-A16, Zoetis Inc. 11. Cosgrove SB, Wren JA, Cleaver DM, et al. A blinded, randomized, placebo-controlled trial of the efficacy and safety of the Janus kinase inhibitor oclacitinib (APOQUEL®) in client-owned dogs with atopic dermatitis. Vet Dermatol. 2013;24(6):587-e142. doi:10.1111/vde.12088. 12. Edwards SH. The Merck Veterinary Manual. 11th ed. Kenilworth, NJ: Merck Sharp & Dohme Corp; 2014. http://merckvetmanual.com/pharmacology/anti-inflammatory-agents/corticosteroids?qt=antiinflammatoryagents&alt=sh. Accessed January 4, 2018. 13. Sousa CA. Glucocosteroids in veterinary dermatology. In: Bonagura JD, Twedt DC, eds. Kirk’s Current Veterinary Therapy. 14th ed. St. Louis, MO: Saunders Elsevier; 2009:400-404.

Allows diagnostic testing

The first step in providing allergic itch relief during diagnostic testing1,2

APOQUEL lets you establish and maintain itch
relief while allowing you to achieve a diagnosis

  • Fast itch control improves quality of life1 while you conduct diagnostic trials
  • Short half-life lets you "turn-on" and "turn-off" itch control during flea control and food trials 

Relieve itch with APOQUEL during an 8-week food trial2

APOQUEL during an 8-week food trial

Zoetis offers 2 best-in-class options for treating allergic itch.

LEARN MORE ABOUT THE ZOETIS DERMATOLOGY PORTFOLIO

SEE WHAT SETS APOQUEL APART FROM STEROIDS

IMPORTANT SAFETY INFORMATION
Do not use APOQUEL® (oclacitinib tablet) in dogs less than 12 months of age or those with serious infections. APOQUEL may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. APOQUEL has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporine. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. APOQUEL has been used safely with many common medications including parasiticides, antibiotics and vaccines.

For more information, please see the full Prescribing Information.

References: 1. Aleo MM, Galvan EA, Fleck TJ, et al. Effects of oclacitinib and prednisolone on skin test sensitivity [abstract]. Vet Dermatol. 2013;24(3):297. 2. Olivry T, Mueller RS, Prélaud P, et al. Critically appraised topic on adverse food reactions of companion animals (1): duration of elimination diets. BMC Vet Res. 2015;11:225. doi:10.1186/s12917-015-0541-3.

APOQUEL is not a steroid

First medicine specifically designed to target canine allergic itch and inflammation1,2

Works differently from steroids and cyclosporine2,3

  • Nonsteroidal APOQUEL targets specific cytokines that cause itch and inflammation, relieving symptoms of allergic skin disease with minimal impact on the immune system

Cytokines involved in dog allergies

APOQUEL inhibits the function of a variety of pruritogenic and proinflammatory cytokines, including JAK1- and JAK3-dependent cytokines involved in dog allergies…

Apoquel controls itch with minimal immune effect

…while having only minimal effect on JAK2-dependent cytokines involved in hematopoiesis and innate immunity

Short-term steroid use can cause side effects

  • 55% of dog owners report side effects with steroids. The most common include4:

    • - Increased hunger and thirst
    • - Excessive urination
  • APOQUEL work differently than steroids.2,3 Side effects reported most often are vomiting and diarrhea5

  • Balancing the need for relief with consideration of side effects can create an emotional "roller coaster" for pet owners

LEARN MORE ABOUT SAFETY WITH APOQUEL

IMPORTANT SAFETY INFORMATION
Do not use APOQUEL® (oclacitinib tablet) in dogs less than 12 months of age or those with serious infections. APOQUEL may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. APOQUEL has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporine. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. APOQUEL has been used safely with many common medications including parasiticides, antibiotics and vaccines.

For more information, please see the full Prescribing Information.

References: 1. Data on file, Press Release, 2014, Zoetis Inc. 2. Gonzales AJ, Bowman JW, Fici G, et al. Oclacitinib (APOQUEL®) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. J Vet Pharmacol Ther. 2014;37(4):317-324. doi:10.1111/jvp.12101. 3. Coutinho AE, Chapman KE. The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights. Mol Cell Endocrinol. 2011;335(1):2-13. doi:10.1016/j.mce.2010.04.005. 4. Data on file, Pet Owner Quantitative Market Research, 2013, Zoetis Inc. 5. Cosgrove SB, Wren JA, Cleaver DM, et al. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. Vet Dermatol. 2013;24(5):479-e114. doi:10.1111/vde.12047.

Fast relief for short- and long-term allergic pruritus—first time, every time

Safe to use in dogs 12 months of age and older

Side effects were similar to placebo over short-term

  • Most common side effects in a short-term clinical trial included vomiting and diarrhea, and were self-limiting1

Can be used long-term for maintenance therapy

Can be used concomitantly with many medications

  • Including NSAIDs, anti-infectives, parasiticides, antifungals and allergen-specific immunotherapy2

  • The use of APOQUEL has not been evaluated in combination with other systemic immunosuppressants, such as corticosteroids and cyclosporine

Not for use in dogs with serious infections, or for use in breeding, pregnant or lactating dogs

IMPORTANT SAFETY INFORMATION
Do not use APOQUEL® (oclacitinib tablet) in dogs less than 12 months of age or those with serious infections. APOQUEL may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. APOQUEL has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporine. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. APOQUEL has been used safely with many common medications including parasiticides, antibiotics and vaccines.

For more information, please see the full Prescribing Information.

References: 1. Cosgrove SB, Wren JA, Cleaver DM, et al. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. Vet Dermatol. 2013;24(5):479-e114. doi:10.1111/vde.12047. 2. Cosgrove SB, Cleaver DM, King VL, et al. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. Vet Dermatol. 2015;26(3):171-179. doi:10.1111/vde.12194. 3. Data on file, Study Report No. A161R-AU-12-096, Zoetis Inc. 4. Cosgrove SB, Wren JA, Cleaver DM, et al. A blinded, randomized, placebo-controlled trial of the efficacy and safety of the Janus kinase inhibitor oclacitinib (APOQUEL®) in client-owned dogs with atopic dermatitis. Vet Dermatol. 2013;24(6):587-e142. doi:10.1111/vde.12088. 5. Data on file, Study Report No. 6962R-14-10-025, Zoetis Inc. 

How to dose APOQUEL

  • The dose of APOQUEL tablets is 0.18 to 0.27 mg/lb (0.4 to 0.6 mg/kg)
  • APOQUEL should be given twice daily (BID) for up to 14 days of therapy and once daily (SID) thereafter for maintenance
  • APOQUEL may be given with or without food
  • APOQUEL may be discontinued without tapering

Apoquel dose chart

DOWNLOAD DOSING GUIDE

EXPERIENCE APOQUEL SUCCESS STORIES

IMPORTANT SAFETY INFORMATION
Do not use APOQUEL® (oclacitinib tablet) in dogs less than 12 months of age or those with serious infections. APOQUEL may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. APOQUEL has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporine. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. APOQUEL has been used safely with many common medications including parasiticides, antibiotics and vaccines.

For more information, please see the full Prescribing Information.

APOQUEL is #1 in veterinatrian and pet owner satisfaction1,2*

Veterinarians feel confident when prescribing APOQUEL

"APOQUEL is a reliable, fast-acting way to ensure the pet finds relief from itching.”3

— Dr Holly Dutton,
North Bay Animal Hospital, FL,
3/5/16

“APOQUEL works well to provide relief, increasing owners' confidence in our recommendation and building trust that we are going to help their pets.”3

— Dr Samantha Lockwood,
Dermatology for Animals, AZ,
3/17/19

“Whenever you solve a problem for a pet owner, it always results in increased trust and more acceptance of other recommendations.”3

— Dr Farid Saleh,
Erlich Animal Hospital, FL,
3/9/19

Pet owners are highly satisfied with APOQUEL treatment for their dogs

Owners of allergic dogs were asked for their APOQUEL reviews:

90% would recommend APOQUEL to a friend4

97% believed APOQUEL improved their dog’s life5

95% said APOQUEL improved their own life5

APOQUEL has changed the lives of dogs and their owners!

"It was like seeing her find herself again!"
— Bijou's owner, 11/10/16

NANI suffered from a grass allergy6
Apoquel (oclacitinib) relieved Nani’s dog allergiesApoquel (oclacitinib) relieved Nani’s dog allergies
NANI suffered from a grass allergy6

[Now Nani] can sleep at night, She can go outside and play. She has a better quality of life.

– Nani's owner, 11/10/16
GUNNER had itching and an infected hot spot6
Apoquel (oclacitinib) relieved Gunner’s dog allergiesApoquel (oclacitinib) relieved Gunner’s dog allergies
GUNNER had itching and an infected hot spot6

Once I left the clinic knowing that the injection of CONVENIA and the APOQUEL were on board initially, and I saw the relief in Gunner, I felt relief myself.

– Gunner's owner, 11/10/16
CAPTAIN did not do well on steroids6
Captain’s owner shares Apoquel reviewCaptain’s owner shares Apoquel review
CAPTAIN did not do well on steroids6

Within a week he had his cone off and he looked like a normal dog!

– Captain's owner, 12/10/13
MOLLY struggled with multiple allergies6
Molly’s owner shares Apoquel reviewsMolly’s owner shares Apoquel reviews
MOLLY struggled with multiple allergies6

[Now] she just has such a different personality…Or maybe she had that personality and it was just masked by all the pain and the suffering before.

– Molly's owner, 12/10/13

EXPLORE RESOURCES FOR YOUR PRACTICE

IMPORTANT SAFETY INFORMATION
Do not use APOQUEL® (oclacitinib tablet) in dogs less than 12 months of age or those with serious infections. APOQUEL may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. APOQUEL has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporine. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. APOQUEL has been used safely with many common medications including parasiticides, antibiotics and vaccines.

For more information, please see the full Prescribing Information.

*Based on survey data from veterinarians (n=250) and pet owners (n=150).

References: 1. Data on file, APOQUEL/CYTOPOINT Vet Tracker Wave 11, 2018, Zoetis Inc. 2. Data on file, APOQUEL/CYTOPOINT Pet Tracker Wave 6, 2019, Zoetis Inc. 3. Data on file, APOQUEL Customer Survey, 2019, Zoetis Inc. 4. Data on file, APOQUEL EEP Pet Owner Aggregate Data, Zoetis Inc. 5. Data on file, Pet Owner Survey Aggregate Report, 2014, Zoetis Inc. 6. Data on file, Pet Owner Case Studies–Bijou, Nani, Gunner, Captain and Molly, Zoetis Inc.

The animal health information contained herein is provided for educational purposes only and is not intended to replace discussions with an animal healthcare professional. Testimonials represent individual experience only and the experiences and opinions herein may be unique to the patient and the speaker. Individual results may vary considering the unique characteristics of the patient.

APOQUEL resources

A new way to save—APOQUEL is now part of Zoetis Petcare Rewards!

Clients can earn money for future veterinary visits with Zoetis Petcare Rewards

With every APOQUEL purchase, pet owners can earn rewards! Rewards can help pay for any product or service at your veterinary practice. Clients can spend their rewards on anything they choose at the veterinary office for their pet's care.

Clinical information

APOQUEL dosing guide

Save the APOQUEL dosing table for reference in your practice.

APOQUEL technical monograph

A comprehensive overview of allergic skin disease and APOQUEL, including pharmacology and clinical trials.

Steroid side effects 1-pager

A simple diagram that reviews short-term and long-term side effects of steroids.

Promotional materials for your practice

Waiting room video

A colorful and compelling 60-second video introduction to APOQUEL. Video is subtitled so it can be played without sound.

Client information sheet

Gives dog owners a quick overview of allergic skin disease and a review of APOQUEL treatment explaining what to expect.

Itch tracker

Helps your clients track the improvement in their dog’s itch. 

Pet owner brochure

An informative, easy-to-understand review of APOQUEL for your customers. It can be used in the waiting room and/or given to owners whose allergic dogs have already been prescribed APOQUEL. 

INDICATIONS
Control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.

IMPORTANT SAFETY INFORMATION
Do not use APOQUEL® (oclacitinib tablet) in dogs less than 12 months of age or those with serious infections. APOQUEL may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. APOQUEL has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporine. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. APOQUEL has been used safely with many common medications including parasiticides, antibiotics and vaccines.

For more information, please see the full Prescribing Information.

The product information provided in this site is intended only for residents of the United States. The products discussed herein may not have marketing authorization or may have different product labeling in different countries. The animal health information contained herein is provided for educational purposes only and is not intended to replace discussions with an animal healthcare professional. All decisions regarding the care of a veterinary patient must be made with an animal healthcare professional, considering the unique characteristics of the patient.

All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted.
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