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APOQUEL® targets specific cytokines that cause itch and inflammation in allergic skin disease, relieving symptoms with minimal impact on the immune system

How does APOQUEL work?

Apoquel MOA JAK2 Image

APOQUEL inhibits the function of a variety of pruritogenic and proinflammatory cytokines, as well as cytokines involved in allergy that are dependent on JAK1 or JAK3 enzyme activity1

Apoquel MOA cytokines Image

APOQUEL has minimal effect on JAK2-dependent cytokines involved in hematopoiesis and innate immunity

Apoquel MOA playBtn itch cycle

APOQUEL is not a corticosteroid, antihistamine or cyclosporine

Control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.

Important Safety Information
Do not use APOQUEL in dogs less than 12 months of age or those with serious infections. APOQUEL may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. APOQUEL has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporine. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. APOQUEL has been used safely with many common medications including parasiticides, antibiotics and vaccines.

For more information, please see the full Prescribing Information.

References: 1. Gonzales AJ, Fleck TJ, Humphrey WR, et al. IL‐31‐induced pruritus in dogs: a novel experimental model to evaluate anti‐pruritic effects of canine therapeutics. Vet Dermatol. 2016;27(1):34-e10. doi:10.1111/vde.12280. 2. Marsella R, Sousa CA, Gonzales AJ, et al. Current understanding of the pathophysiologic mechanisms of canine atopic dermatitis. J Am Vet Med Assoc. 2012;241(2):194-207. doi:10.2460/javma.241.2.194.

The product information provided in this site is intended only for residents of the United States. The products discussed herein may not have marketing authorization or may have different product labeling in different countries. The animal health information contained herein is provided for educational purposes only and is not intended to replace discussions with an animal healthcare professional. All decisions regarding the care of a veterinary patient must be made with an animal healthcare professional, considering the unique characteristics of the patient.

All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted.

© 2017 Zoetis Services LLC. All rights reserved. APQ-00371

Cytokines are protein messages sent from one cell to another, stimulating the receiving cell to action. Think of them as “text messages” between neighbors2

Janus kinases (JAKs) are intracellular enzymes that are activated when the “text message” (cytokine) is received, triggering itch and inflammation in the skin2