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CERENIA® (maropitant citrate)

The only approved veterinary antiemetic

Cerenia

CERENIA (maropitant citrate) Injectable Solution is indicated for the prevention and treatment of acute vomiting in dogs 8 weeks of age and older and for the treatment of vomiting in cats 16 weeks of age and older.

CERENIA tablets are indicated for the prevention of acute vomiting in dogs 8 weeks of age and older and the prevention of vomiting due to motion sickness in dogs 16 weeks of age and older.

 

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    • Unique mode of action works in the emetic center, where all vomiting pathways converge, preventing and treating vomiting from multiple causes1-3
    • Rapid onset of action and 24-hour efficacy4-9
    • Once-daily dosing is easier for patients and enhances owner compliance
    • Non-sedating
  • INJECTABLE (dogs and cats)

    For Prevention of Acute Vomiting in dogs 8 weeks and older and for the Treatment of Vomiting in cats 16 weeks and older

    Administer CERENIA Injectable Solution subcutaneously at 1 mg/kg (0.45 mg/lb) equal to 1 mL/10kg (1 mL/22 lb) of body weight once daily for up to 5 consecutive days. Use of refrigerated product may reduce the pain response associated with the injection.

    For dogs, CERENIA Injectable Solution may be used interchangeably with CERENIA Tablets for once daily dosing for the prevention of acute vomiting. 

    TABLETS (dogs only)

    For Prevention of Acute Vomiting in dogs 8 weeks and older
    Administer CERENIA Tablets orally at a minimum dose of 2 mg/kg (0.9 mg/lb) body weight once daily for up to 5 consecutive days.

    Prevention of Acute Vomiting
    Minimum of 2 mg/kg BW Dosing
     

    Cerenia PI Table

    CERENIA Tablets may be used interchangeably with CERENIA Injectable Solution for once daily dosing for the prevention of acute vomiting.

    For Prevention of Vomiting Due to Motion Sickness in dogs 16 weeks and older
    Administer CERENIA Tablets orally at a minimum dose of 8 mg/kg (3.6 mg/lb) body weight once daily for up to 2 consecutive days. Dogs should be fasted 1 hour prior to administration of CERENIA Tablets. Administer CERENIA Tablets 2 hours prior to travel.

    Prevention of Vomiting Due to Motion Sickness
    Minimum of 8 mg/kg BW Dosing
     
     

    Cerenia_PI_Table2

     

     

  • 1. Sedlacek HS, Ramsey DS, Boucher JF, et al. Comparative efficacy of maropitant and selected drugs in preventing emesis induced by centrally or peripherally acting emetogens in dogs. J Vet Pharm Therap 2008;31:533-537.
    2. Quartara L, Maggi CA.  The tachykinin NK1 Receptor.  Part II: Distribution and pathophysiological roles. Neuropeptides 1998;32:1-49.
    3. Washabau RJ, Elie MS.  Antiemetic Therapy.  In: Kirk RW, Bonagura JD, eds.  Kirk’s Current Veterinary Therapy XII Small Animal Practice.  Philadelphia: WB Saunders; 1995:679-684.
    4. De la Puente-Redondo VA, Tile N, Rowan T, et al. Efficacy of maropitant for treatment and prevention of emesis caused by intravenous infusion of cisplatin in dogs. AJVR 2007;68:48-56.
    5. Data on file, Zoetis Study Report 1960C-60-03-672. Dose confirmation of the efficacy of maropitant for apomorphine-induced emesis in dogs.
    6. Data on file, Zoetis Study Report 1960C-60-01-588. Dose confirmation of the efficacy of maropitant for apomorphine-induced emesis in dogs.
    7. De La Puente-Redondo VA, Siedek EM, Benchaoui HA, et al. The anti-emetic efficacy of maropitant (Cerenia™) in the treatment of ongoing emesis caused by a wide range of underlying clinical aetiologies in canine patients in Europe. J Small Anim Pract 2007;48:93-98.
    8. Data on file, Zoetis Study Report 5961P-36-01-247. Preliminary dose selection study of maropitant administered for the prevention of emesis in dogs.
    9. Data on file, Zoetis Study Report 5961P-36-01-248. Preliminary study to select the dose of maropitant required for the prevention of emesis and nausea in dogs.


Important Safety Information
The safe use of CERENIA has not been evaluated in dogs or cats used for breeding, or in pregnant or lactating bitches or queens. The safe use of CERENIA has not been evaluated in patients with gastrointestinal obstruction, or patients that have ingested toxins. Use with caution in patients with hepatic dysfunction. CERENIA Injectable is recommended for dogs 8 weeks and older for prevention and treatment of acute vomiting and for cats 16 weeks and older for the treatment of vomiting. CERENIA Tablets are recommended for dogs 8 weeks and older for prevention of acute vomiting and for dogs 16 weeks and older for prevention of vomiting due to motion sickness. The most common side effects seen in dogs and cats administered CERENIA are pain/vocalization (injectable), depression/lethargy, anorexia, anaphylaxis, ataxia, convulsions, and hypersalivation, and vomiting.

For more safety information, see full prescribing information.