Print page content Print
Increase text size Decrease text size
Text Size


The safety you expect from a cephalosporin. The power of an injectable.

Since the approval of CONVENIA® (cefovecin sodium), the pharmacovigilance data have been consistent with:

  • Events reported during the preapproval target animal safety studies.
  • The clinical efficacy and safety field studies.
  • The class effects described on the CONVENIA U.S. label and in the veterinary literature for the β-lactam group of antimicrobials.

CONVENIA has been used concomitantly with many medications, including antibiotics, parasiticides, NSAIDs, vaccines and anesthetics.

Clinical efficacy & safety field studies3,4

A total of 320 dogs (maximum age 19 years) and 291 cats (maximum age 21 years) were included in a field study safety analysis conducted in 26 veterinary hospitals in the United States.

Preapproval field efficacy and safety studies: side effects

 Preapproval studies: table showing no. of dogs with adverse reactions, CONVENIA vs. cefadroxil
 Preapproval studies: table showing no. of cats with adverse reactions, CONVENIA vs. cefadroxil

Laboratory safety studies10

CONVENIA was tested at 1.5 times, 4.5 times and 7.5 times the label dose every 7 days for a total of 5 injections in dogs and cats.

CONVENIA was evaluated in a single injection 22.5 times the normal dose in dogs and cats.

Summary of field and laboratory safety studies

  • Occasional gastrointestinal signs were observed, with the incidence increasing in a dose-related manner in the laboratory studies.
  • Mild elevations in BUN and/or creatinine were observed in a few dogs and cats in laboratory and field studies and were not associated with clinical signs of organ dysfunction.
  • Some injection site irritation, vocalization and edema were observed following injection in the groups given 22.5 times (180 mg/kg) the label dose. The edema resolved within 8–24 hours. When injection sites were evaluated histopathologically in cats, minimal signs of active inflammation were observed in only a few cats even at elevated doses (1 given a placebo, 1 given 4.5 times the label dose and 1 given 7.5 times the label dose).
  • Based on the safety and efficacy studies CONVENIA injectable for dogs and cats when used under label conditions is safe and effective.11

Zoetis supports the responsible use of antibiotics in animals and people.
Learn about our commitment to antibiotic stewardship »

IMPORTANT SAFETY INFORMATION: People with known hypersensitivity to penicillin or cephalosporins should avoid exposure to CONVENIA. Do not use in dogs or cats with a history of allergic reactions to penicillins or cephalosporins. Side effects for both dogs and cats include vomiting, diarrhea, decreased appetite/anorexia and lethargy. See full Prescribing Information.



Mon–Fri, 8:30am–8:00pm ET

This site is intended for U.S. Animal Healthcare Professionals. The product information provided in this site is intended only for residents of the United States. The products discussed herein may not have marketing authorization or may have different product labeling in different countries. The animal health information contained herein is provided for educational purposes only and is not intended to replace discussions with an animal healthcare professional. All decisions regarding the care of a veterinary patient must be made with an animal healthcare professional, considering the unique characteristics of the patient.

All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. ©2021 Zoetis Services LLC. All rights reserved.