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The safety you expect from a cephalosporin. The power of an injectable.

Since the approval of CONVENIA® (cefovecin sodium), the pharmacovigilance data have been consistent with:

  • Events reported during the preapproval target animal safety studies.
  • The clinical efficacy and safety field studies.
  • The class effects described on the CONVENIA U.S. label and in the veterinary literature for the β-lactam group of antimicrobials.

CONVENIA has been used concomitantly with many medications, including antibiotics, parasiticides, NSAIDs, vaccines and anesthetics.

Clinical efficacy & safety field studies3,4

A total of 320 dogs (maximum age 19 years) and 291 cats (maximum age 21 years) were included in a field study safety analysis conducted in 26 veterinary hospitals in the United States.

Preapproval field efficacy and safety studies: side effects

 Preapproval studies: table showing no. of dogs with adverse reactions, CONVENIA vs. cefadroxil
 Preapproval studies: table showing no. of cats with adverse reactions, CONVENIA vs. cefadroxil

Laboratory safety studies10

CONVENIA was tested at 1.5 times, 4.5 times and 7.5 times the label dose every 7 days for a total of 5 injections in dogs and cats.

CONVENIA was evaluated in a single injection 22.5 times the normal dose in dogs and cats.

Summary of field and laboratory safety studies

  • Occasional gastrointestinal signs were observed, with the incidence increasing in a dose-related manner in the laboratory studies.
  • Mild elevations in BUN and/or creatinine were observed in a few dogs and cats in laboratory and field studies and were not associated with clinical signs of organ dysfunction.
  • Some injection site irritation, vocalization and edema were observed following injection in the groups given 22.5 times (180 mg/kg) the label dose. The edema resolved within 8–24 hours. When injection sites were evaluated histopathologically in cats, minimal signs of active inflammation were observed in only a few cats even at elevated doses (1 given a placebo, 1 given 4.5 times the label dose and 1 given 7.5 times the label dose).

Zoetis supports the responsible use of antibiotics in animals and people.
Learn about our commitment to antibiotic stewardship »

IMPORTANT SAFETY INFORMATION: People with known hypersensitivity to penicillin or cephalosporins should avoid exposure to CONVENIA. Do not use in dogs or cats with a history of allergic reactions to penicillins or cephalosporins. Side effects for both dogs and cats include vomiting, diarrhea, decreased appetite/anorexia and lethargy. See full Prescribing Information.



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