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CYTOPOINT is now approved for the treatment of allergic dermatitis! Learn more
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animal healthcare professionals

CYTOPOINT® treatment efficacy

CYTOPOINT® treatment efficacy

CYTOPOINT helps relieve itch in dogs within 24 hours while giving skin time to heal after only one injection1

Effective itch relief within one day

  • In a laboratory study, a single injection of CYTOPOINT was shown to significantly decrease IL-31-induced pruritus in dogs within one day of injection and for 28 days2
  • CYTOPOINT decreased pruritus by ≥50% in all dogs at Day 1, and in 95% of dogs at Day 282
CYTOPOINT Canine Itch Relief Efficacy Chart
  • Least squares mean (±SE).
  • Day -7 means are arithmetic mean values.
  • Statistically significant (P<0.0001) compared to placebo.

Success with CYTOPOINT treatment

87.8%

were treatment successes after one injection3†

77%

achieved a PVAS reduction of ≥50%3

MAJORITY
of dogs

showed clinical improvement within 24 hours

Success in dogs with all reported types of allergic dermatitis

No significant difference in success between disease types3

82%
of dogs with allergic dermatitis of undetermined cause
WERE TREATMENT SUCCESSES
  • All 10 dogs with food allergies and atopic dermatitis were treatment successes with CYTOPOINT
  • All study dogs, regardless of dermatitis type (i.e., allergic or atopic), were likely to be treatment successes
  • 93.3% (56/60) of large/giant dogs were treatment successes

Success across patient types

No significant differences in success with CYTOPOINT for3:

Age at onset of allergic signs

Duration of allergic dermatitis symptoms

Age at time of
first administration

  • Adverse events, reported by owners in 8.3% of dogs, were minor and resolved without medical intervention.
  • Treatment success for owner-assessed pruritus control was empirically defined as ≥2 cm reduction in PVAS from baseline on the day of assessment.
  • Owners described their dog’s level of itching by marking a point on a vertical line between extremely itchy and not itchy. Itching includes scratching, biting, licking, chewing and rubbing.4
  • Time until efficacy was known in 68 out of 135 dogs.

Fast, lasting canine atopic itch relief

  • CYTOPOINT starts working in 24 hours, continues working for 4 to 8 weeks* after 1 injection to help reduce pruritus and lesions associated with canine atopic dermatitis1

CYTOPOINT Canine Itch Relief Efficacy Chart
CYTOPOINT VAS Efficacy Score Chart

Defining treatment success

  • Repeat administration every 4 to 8 weeks as needed in individual patients.1
  • Successful canine pruritus relief was defined as a reduction in pruritus score of ≥20 mm on the visual analog scale (VAS). VAS is an owner-assessed scale that measures itch along a continuum from normal dog (no itch) to extremely severe itch, using numbers from 0 to 100. VAS scoring instruments were given to owners, accompanied by explanations of how to record itch based on the behavior of the dog. Owners recorded itch on Days 1, 2, 3, 7 and every 7 days thereafter.1
  • Statistically significant compared to placebo (P≤0.05).
  • Day 0 means are arithmetic mean values.

CYTOPOINT gives damaged skin a chance to heal after 1 injection1

CYTOPOINT canine skin improvement
CADESI-03 scores after CYTOPOINT

Defining treatment success

  • Treatment success was defined as a ≥50% reduction from baseline in skin condition scores as assessed by veterinarians using the Canine Atopic Dermatitis Extent and Severity Index (CADESI-03) score. CADESI-03 skin condition assessment consisted of an evaluation of erythema, lichenification, excoriation and self-induced alopecia at 62 body sites.1
  • Statistically significant compared to placebo (P≤0.05).
  • Day 0 means are arithmetic mean values.
CADESI-O3 measures CYTOPOINT efficacy

Indications: CYTOPOINT has been shown to be effective for the treatment of dogs against allergic dermatitis and atopic dermatitis.

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This site is intended for U.S. Animal Healthcare Professionals.

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