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CYTOPOINT is now approved for the treatment of allergic dermatitis! Learn more
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This site is intended for U.S.
animal healthcare professionals

CYTOPOINT® treatment efficacy

CYTOPOINT® treatment efficacy

CYTOPOINT helps relieve itch in dogs within 24 hours while giving skin time to heal after only one injection1

Effective itch relief within one day

  • In a laboratory study, a single injection of CYTOPOINT was shown to significantly decrease IL-31-induced pruritus in dogs within one day of injection and for 28 days2
  • CYTOPOINT decreased pruritus by ≥50% in all dogs at Day 1, and in 95% of dogs at Day 282
CYTOPOINT Canine Itch Relief Efficacy Chart
  • Least squares mean (±SE).
  • Day -7 means are arithmetic mean values.
  • Statistically significant (P<0.0001) compared to placebo.

Success with CYTOPOINT treatment


were treatment successes after one injection3†


achieved a PVAS reduction of ≥50%3

of dogs

showed clinical improvement within 24 hours

Success in dogs with all reported types of allergic dermatitis

No significant difference in success between disease types3

of dogs with allergic dermatitis of undetermined cause
  • All 10 dogs with food allergies and atopic dermatitis were treatment successes with CYTOPOINT
  • All study dogs, regardless of dermatitis type (i.e., allergic or atopic), were likely to be treatment successes
  • 93.3% (56/60) of large/giant dogs were treatment successes

Success across patient types

No significant differences in success with CYTOPOINT for3:

Age at onset of allergic signs

Duration of allergic dermatitis symptoms

Age at time of
first administration

  • Adverse events, reported by owners in 8.3% of dogs, were minor and resolved without medical intervention.
  • Treatment success for owner-assessed pruritus control was empirically defined as ≥2 cm reduction in PVAS from baseline on the day of assessment.
  • Owners described their dog’s level of itching by marking a point on a vertical line between extremely itchy and not itchy. Itching includes scratching, biting, licking, chewing and rubbing.4
  • Time until efficacy was known in 68 out of 135 dogs.

Fast, lasting canine atopic itch relief

  • CYTOPOINT starts working in 24 hours, continues working for 4 to 8 weeks* after 1 injection to help reduce pruritus and lesions associated with canine atopic dermatitis1

CYTOPOINT Canine Itch Relief Efficacy Chart
CYTOPOINT VAS Efficacy Score Chart

Defining treatment success

  • Repeat administration every 4 to 8 weeks as needed in individual patients.1
  • Successful canine pruritus relief was defined as a reduction in pruritus score of ≥20 mm on the visual analog scale (VAS). VAS is an owner-assessed scale that measures itch along a continuum from normal dog (no itch) to extremely severe itch, using numbers from 0 to 100. VAS scoring instruments were given to owners, accompanied by explanations of how to record itch based on the behavior of the dog. Owners recorded itch on Days 1, 2, 3, 7 and every 7 days thereafter.1
  • Statistically significant compared to placebo (P≤0.05).
  • Day 0 means are arithmetic mean values.

CYTOPOINT gives damaged skin a chance to heal after 1 injection1

CYTOPOINT canine skin improvement
CADESI-03 scores after CYTOPOINT

Defining treatment success

  • Treatment success was defined as a ≥50% reduction from baseline in skin condition scores as assessed by veterinarians using the Canine Atopic Dermatitis Extent and Severity Index (CADESI-03) score. CADESI-03 skin condition assessment consisted of an evaluation of erythema, lichenification, excoriation and self-induced alopecia at 62 body sites.1
  • Statistically significant compared to placebo (P≤0.05).
  • Day 0 means are arithmetic mean values.
CADESI-O3 measures CYTOPOINT efficacy

Indications: CYTOPOINT has been shown to be effective for the treatment of dogs against allergic dermatitis and atopic dermatitis.



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