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CYTOPOINT™ starts working within 24 hours, continues working for 4 to 8 weeks after 1 injection1

*Successful pruritus relief was defined as a reduction in pruritus score of ≥20 mm on the visual analog scale (VAS). VAS is an owner-assessed scale that measures itch along a continuum from normal dog (no itch) to extremely severe itch, using numbers from 0 to 100. VAS scoring instruments were given to owners, accompanied by explanations of how to record itch based on the behavior of the animal. Owners recorded itch on Days 1, 2, 3, 7 and every 7 days thereafter.1

Significantly different compared to placebo (P≤0.05).

Indication: CYTOPOINT aids in the reduction of clinical signs associated with atopic dermatitis in dogs.

Reference: 1. Data on file, Study Report No. C863R-US-12-018, Zoetis LLC.

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© 2016 Zoetis Services LLC. All rights reserved. CYT-00090

STUDY DESIGN

A single 2.0 mg/kg dose of CYTOPOINT (n=50) or placebo (n=52) was administered subcutaneously on Day 0 in this randomized, double-blind, placebo-controlled study of dogs diagnosed with atopic dermatitis. The primary effectiveness endpoints were treatment success in pruritus as assessed by owners on a VAS (success defined as a ≥20 mm reduction in pruritus scores compared to Day 0) and by investigators with CADESl-03 (success defined as a ≥50% decrease in CADESl-03 score compared to Day 0).1