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The first monoclonal antibody therapy for canine atopic dermatitis

CYTOPOINT™ interrupts the itch cycle, allowing dogs to stop scratching so damaged skin can heal

Cytopoint Professional MOA Itch Cycle graphic

EXPOSURE: Allergens enter via the skin, often due to a disrupted or dysfunctional epidermal barrier2

2 SENSITIZATION: Allergens are detected by the immune system, priming immune cells to respond to the allergens in the future2
3 CYTOKINE RELEASE: Exposure to allergens triggers T-cell activation and the release of itch- and inflammation-causing cytokines such as IL-312
4 JAK ENZYME ACTIVATION: IL-31 activates peripheral nerves via the JAK-STAT pathway, resulting in transmission of the itch signal to the brain3
5 ITCH/SCRATCH STIMULATION: The itch signal in the brain triggers scratching behavior. This, combined with cytokine-induced inflammation, further disrupts the epidermal barrier2,4
6 EPIDERMAL DAMAGE: The weakened barrier makes the dog more vulnerable to transepidermal entry of allergens, thus restarting and perpetuating the cycle of itch2

Zoetis' extensive research into the itch cycle has resulted in two innovative and highly targeted therapies, giving veterinarians the flexibility to offer customized treatment to canine atopic dermatitis patients.

Visit our website to learn more about APOQUEL® (oclacitinib tablet), a daily oral tablet offering fast and safe relief of itch in dogs with allergic dermatitis and atopic dermatitis.

Indication: CYTOPOINT aids in the reduction of clinical signs associated with atopic dermatitis in dogs.

APOQUEL Indication: Control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.

IMPORTANT SAFETY INFORMATION: Do not use APOQUEL in dogs less than 12 months of age or those with serious infections. APOQUEL may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. APOQUEL has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. APOQUEL has been used safely with many common medications including parasiticides, antibiotics and vaccines. For more information, please see the full Prescribing Information.

References: 1. Data on file, Press Release, August 2015, Zoetis LLC. 2. Marsella R, Sousa CA, Gonzales AJ, et al. Current understanding of the pathophysiologic mechanisms of canine atopic dermatitis. J Am Vet Med Assoc. 2012;241(2):194-207. doi:10.2460/javma.241.2.194. 3. Gonzales AJ, Humphrey WR, Messamore JE, et al. Interleukin-31: its role in canine pruritus and naturally occurring canine atopic dermatitis. Vet Dermatol. 2013;24(1):48-53. doi:10.1111/j.1365-3164.2012.01098.x. 4. Olivry T, DeBoer DJ, Favrot C, et al. Treatment of canine atopic dermatitis: 2010 clinical practice guidelines from the International Task Force on Canine Atopic Dermatitis. Vet Dermatol. 2010;21(3): 233-248. doi:10.1111/j.1365-3164.2010.00889.x.

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