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Veterinarians’ Trusted Source for Heartworm Treatment.

DIROBAN® (melarsomine dihydrochloride)
Zoetis is the only animal health company that offers canine heartworm prevention, detection and treatment.



Reliable. Recommended.

  • Melarsomine dihydrochloride is the preferred treatment for heartworm disease by the American Heartworm Society and Companion Animal Parasite Council.1-2
  • The sooner adult and immature worms are killed, the sooner your patient and client return to their normal lives.
  • Helps preserve the human-animal bond by shortening the recovery time over slow kill.
  • Zoetis provides clinics and pet owners with support to help educate and manage heartworm treatment expectations.
  • Here when you need it.
    • Immiticide® (melarsomine dihydrochloride) experienced intermittent supply shortages.3

Slow Kill Treatment

Why Slow Kill Is the Inferior Treatment

  • The American Heartworm Society does NOT recommend slow kill as a treatment of heartworm disease.1
  • The longer adult worms are present, pathology continues to develop. Treatment with DIROBAN will shorten the duration of infection by months or even years.
  • When slow kill is used as a treatment, up to 20% of heartworm-infected dogs will continue to have persistent circulating microfilaria.4
    • Those dogs act as reservoirs for other dogs living nearby.4
  • With the slow kill treatment, dogs should be restricted from activity for up to 2 years;5 when treating with DIROBAN, the recommended period of restricted activity is only 12 weeks.2
  • Slow kill requires 100% pet owner compliance of monthly dosing for the duration of treatment up to 2 years.5 With DIROBAN, only 2 to 3 veterinary administrated doses are required during treatment.6

When compliance is a top concern, why take the risk?


A Product You Know, a Company You Can Rely On

  • The active ingredient in DIROBAN, melarsomine dihydrochloride, has been demonstrated to be safe and effective in all dogs with Class 1, 2 and 3 heartworm disease.6
  • Laboratory and clinical field trials demonstrated that treatment with melarsomine dihydrochloride reduces and/or clears Dirofilaria immitis infection in dogs with Class 1. 2 and 3 heartworm disease.6
Diroban Efficacy Chart



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This site is intended for U.S. Animal Healthcare Professionals. The product information provided in this site is intended only for residents of the United States. The products discussed herein may not have marketing authorization or may have different product labeling in different countries. The animal health information contained herein is provided for educational purposes only and is not intended to replace discussions with an animal healthcare professional. All decisions regarding the care of a veterinary patient must be made with an animal healthcare professional, considering the unique characteristics of the patient.

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