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(doxycycline hyclate)

Treats and controls periodontal disease in dogs

DOXIROBE Gel (doxycycline hyclate) is indicated for the treatment and control of periodontal disease in dogs. A single treatment of DOXIROBE Gel can reduce periodontal pocket depth, increase reattachment and reduce gingival inflammation.1

Each unit of DOXIROBE Gel contains Syringe A (polymer delivery system) and Syringe B (doxycycline) which when mixed in approximately 0.5 ml of doxycycline system. Available as a 3-unit carton (containing 1 additional blunt cannula).

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  • • One treatment can reduce periodontal pocket depth, increase reattachment, and reduce gingival inflammation.1

    • Special syringe with cannula permits injection of doxycycline directly into infected periodontal pockets, providing local antimicrobial action at the infection site for several weeks.

    • Provides better results than antibiotics and scaling alone.1

    • Biodegrades over time, eliminating the need to physically remove it.

    • Improves gingival health in 2 to 4 weeks.


    Teeth should be cleaned and scaled prior to application of the product.

    If required, root plaining and debridement of affected sites should be performed. The product is applied with the animal under sedation or anesthesia. Use as many units as required to fill the periodontal pockets of affected teeth.

    Treatment and control of periodontal disease requires a comprehensive program of routine scaling and cleaning, home care and dental hygiene (e.g., brushing, rinses or the use of chewing devices) in addition to application of this product. Severe cases may require surgical intervention.

    Reconstituted product not used on the day of mixing should be stored in the resealable foil pouch at room temperature (15-25°C or 59-77°F) and used within 3 days of reconstitution. Ten additional exchanges between syringes should be performed if reconstituted product has been stored.

  • 1. Zetner K, Rothmuller G. The treatment of periodontal pockets with the new perioceutic DOXIROBE. Vet Ther. 2002;3(4):441-452.

Do not use DOXIROBE Gel in dogs under 1 year of age, because the use of tetracycline during tooth development has been associated with permanent discoloring of teeth.

See full Prescribing Information, here.



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