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What is the indication for Canine Atopic Dermatitis Immunotherapeutic*?
Canine Atopic Dermatitis Immunotherapeutic* aids in the reduction of clinical signs associated with atopic dermatitis in dogs.
How does Canine Atopic Dermatitis Immunotherapeutic* work?
Canine Atopic Dermatitis Immunotherapeutic* is a ready-to-use, sterile liquid containing caninized anti-cIL-31 monoclonal antibody (mAb). This mAb specifically targets and neutralizes canine interleukin (IL)-31, which is involved in sending the itch signal to the brain.1 By targeting the IL-31 pathway, Canine Atopic Dermatitis Immunotherapeutic* interrupts the cycle of itch in dogs with atopic dermatitis.
How long does Canine Atopic Dermatitis Immunotherapeutic* remain in the body?
Canine Atopic Dermatitis Immunotherapeutic* remains in circulation for several weeks.2 Like other naturally occurring antibodies and antibody-antigen complexes, it is eliminated via normal protein degradation pathways.
A historical perspective on the therapeutic use of antibodies
*This product license is conditional. Efficacy and potency test studies in progress.
References: 1. Gonzales AJ, Humphrey WR, Messamore JE, et al. Interleukin-31: its role in canine pruritus and naturally occurring canine atopic dermatitis. Vet Dermatol. 2013;24:48–53.e11-2. doi:10.1111/j.1365-3164.2012.01098.x. 2. Data on file, Study Report No. C863R-US-12-018. Zoetis LLC.
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