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Three dogs with mosquito

Any Dog Could Be
Infected, Anywhere

Clinical Signs Versus External Signs

Damage happens before standard heartworm antigen tests turn positive.1

Heartworm-positive heart Heart showing vascular damage Heart showing significant pulmonary damage

The heart of a heartworm-positive dog is dissected to the level of the pulmonary valve.

A normal pulmonary artery like this can suffer damage from one or two heartworms long before diagnosis.

Significant pulmonary damage can occur in as little as 5 months.1

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Heartworm Disease Has Been Diagnosed in All 50 States2

>21% Increase in the average number of cases of canine heartworm disease*4

Average number of cases per reporting clinic:

  • <1 cases/clinic
  • 1-5 cases/clinic
  • 6-25 cases/clinic
  • 26-50 cases/clinic
  • 51-99 cases/clinic
  • >100 cases/clinic

Heartworm Disease Incidence 2016 Map3

2007 Incidence Map 2013 Incidence Map 2016 Incidence Map

2007 2013 2016

Prevention Is Less Expensive Than Treatment

Treatment isn’t just expensive

  • It involves multiple injections of arsenic-based melarsomine dihydrochloride next to the spine, and often requires hospitalization5
  • Heartworm disease leaves the dog with serious and permanent damage to invaded organs even after the worms are gone1
  • The process of treatment is a miserable experience for dogs, pet owners, and veterinarians
Illustration of balancing scales showing heartworm prevention vs heartworm treatment

Heartworm Prevention vs Treatment6

Illustration of balancing scales showing heartworm prevention vs heartworm treatment

*Per veterinary clinic 2013-2016.
Average cost for a 40-lb dog.


Stock photo of Opera House in Sydney, Australia

#1Prescribed Heartworm Preventative in Australia

Since 2000, doctors have administered ProHeart 12 in Australia, the second-largest canine heartworm market in the world.

Known in Australia as ProHeart SR-12.

IMPORTANT SAFETY INFORMATION: Use PROHEART 12 in dogs 12 months of age or older. Do not administer to dogs that are sick, debilitated, underweight, have a history of weight loss, or to those previously found to be hypersensitive to the drug. Hypersensitivity reactions may occur in some dogs when PROHEART 12 is administered alone or with vaccines. Anaphylactic and anaphylactoid reactions can result in death and should be treated immediately with the same measures used to treat hypersensitivity reactions to vaccines and other injectable products. The most common reported side effects in clinical trials were vomiting, lethargy, diarrhea, and anorexia. People should avoid inhalation, contact with eyes, or accidental self-injection. Certification is required before veterinarians and staff administer PROHEART 12. See full Prescribing Information.

Reference: 1. Jones, S. Heartworm disease: What lies beneath; DVM 360, April 19, 2018. 2. AHS Canine Guidelines 2018. 3. Heartworm Incidence Maps. Accessed March 8, 2019. 4. Drake, Jason and Scott Wiseman. Increasing incidence of Dirofilaria immitis in dogs in USA with focus on the southeast region 2013 – 2016. Parasites & Vectors (2018) 11:39. 5. Rehm C. Do your heartworm protocols need an update? DVM 360. Posted February 11, 2019. Accessed March 7, 2019. 6. The costs of heartworm treatment. American Heartworm Society. Accessed January 23, 2019.

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