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Administering
SILEO®

(dexmedetomidine oromucosal gel)

VETERINARIAN FAQs (PDF)

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SILEO® (dexmedetomidine oromucosal gel) is the first and only FDA-approved treatment for canine noise aversion. SILEO is designed for easy, at-home administration by the pet owner.

As with any new medication, it is important that the dog owner receives hands-on training on how to administer the treatment.

Review the dosing administration instructions to:

  • Ensure that the pet owner wears gloves
  • Confirm the correct dose
  • Reinforce that the locking ring needs to be in the lock position before administering
  • Be sure that the pet owner understands that SILEO is administered between the cheek and gum and that it is not swallowed

SILEO gel is presented in a 3 mL multidose oral syringe that can be used for repeated doses on an as-needed basis. The gel is applied between the cheek and gum for transmucosal absorption. If SILEO is ingested, due to extensive first pass metabolism by the liver, little dexmedetomidine will be absorbed; therefore SILEO may be ineffective. If swallowed, allow at least two hours before applying the next dose.

SILEO Dosing is Tailored to the Situation


The first dose can be administered:

  • Approximately 30 to 60 minutes before the fear and/or anxiety eliciting noise stimulus
  • Or immediately after the dog shows first signs of anxiety or fear related to noise
  • Or when the owner detects a typical noise stimulus (e.g., fireworks) eliciting anxiety or fear in the dog

If noise lasts greater than 2–3 hours and the dog’s signs of fear and/or anxiety reappear, another dose may be given:

  • At minimum intervals of 2 hours between doses
  • Up to five doses can be given during one noise event

If there is any SILEO remaining in the syringe, the syringe should be returned to the carton to protect it from light. If the remaining portion of the syringe is not used within 2 weeks, it should be discarded according to local and federal regulations.

Videos

How to Administer Sileo® Correctly

Further Dosing



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Dosing by Body Weight

A pet owner can easily determine the appropriate dose by looking up their dog’s weight on this dosing chart, which will indicate the corresponding number of dots the dog should receive.

 

Instructions for Dosing

Before using a new syringe, an initial setup is required. Detailed instructions are provided on the package insert.



VETERINARIAN FAQs (PDF)

Download
Sign in to Order** If you are a customer located in Hawaii, contact your local Zoetis Distributor to order.

Important Safety Information: Do not use SILEO in dogs with severe cardiovascular disease, respiratory, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue or in dogs hypersensitive to dexmedetomidine or to any of the excipients. SILEO should not be administered in the presence of preexisting hypotension, hypoxia, or bradycardia. Do not use in dogs sedated from previous dosing. SILEO has not been evaluated in dogs younger than 16 weeks of age or in dogs with dental or gingival disease that could have an effect on the absorption of SILEO. SILEO has not been evaluated for use in breeding, pregnant, or lactating dogs. Transient pale mucous membranes at the site of application may occur with SILEO use. Other uncommon adverse reactions included emesis, drowsiness or sedation. Handle gel-dosing syringes with caution to avoid direct exposure to skin, eyes or mouth. SILEO has not been evaluated for aversion behaviors to thunderstorms. See full Prescribing Information.