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Sileo (dexmedetomidine otomucosal gel)

Canine Noise Aversion

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  • On-demand CE courses and live consultations with boarded veterinary behaviorists
  • Tools to prepare dog owners for upcoming noise aversion triggers
  • Tools to diagnose noise-averse dogs and measure case progress

Loud noises
can be scary.

SILEO® (dexmedetomidine oromucosal gel) is the first FDA-approved medication indicated for the treatment of canine noise aversion.

At least one-third of dogs in the United States have noise aversion.1

Dogs experiencing noise aversion are distressed and suffering. They can damage property, injure themselves or escape. The suffering associated with self-inflicted trauma is readily recognized, but the physiological and emotional toll experienced by dogs with less obvious signs of noise aversion is often overlooked.

Learn more about canine noise aversion »

SILEO helps to alleviate signs of noise aversion by:

    • Calming without sedating, so that the dog remains fully functional to interact normally with the family

  • Reducing the dog’s suffering and distress and, subsequently, the pet owner’s stress, helping to preserve the human-animal bond
Sign in to Order* If you are a customer in Hawaii, please contact your local Zoetis Sales Representative or Hawaii Mega-Cor to place your order.
Sign in to Order* If you are a customer in Hawaii, please contact your local Zoetis Sales Representative or Hawaii Mega-Cor to place your order.

Important Safety Information: Do not use SILEO in dogs with severe cardiovascular disease, respiratory, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue or in dogs hypersensitive to dexmedetomidine or to any of the excipients. SILEO should not be administered in the presence of preexisting hypotension, hypoxia, or bradycardia. Do not use in dogs sedated from previous dosing. SILEO has not been evaluated in dogs younger than 16 weeks of age or in dogs with dental or gingival disease that could have an effect on the absorption of SILEO. SILEO has not been evaluated for use in breeding, pregnant, or lactating dogs or for aversion behaviors to thunderstorms. Transient pale mucous membranes at the site of application may occur with SILEO use. Other uncommon adverse reactions included emesis, drowsiness or sedation. Handlers should avoid direct exposure of SILEO to their skin, eyes or mouth. Failure to lock the ring-stop on the syringe before dosing SILEO could potentially lead to an accidental overdose. Always review INSTRUCTIONS FOR USE before dispensing and dosing. See full Prescribing Information.


  • 1. Based on online survey conducted by Harris Poll on behalf of Zoetis in November 2013 among 784 dog owners.



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This site is intended for U.S. Animal Healthcare Professionals. The product information provided in this site is intended only for residents of the United States. The products discussed herein may not have marketing authorization or may have different product labeling in different countries. The animal health information contained herein is provided for educational purposes only and is not intended to replace discussions with an animal healthcare professional. All decisions regarding the care of a veterinary patient must be made with an animal healthcare professional, considering the unique characteristics of the patient.

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