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Sileo (dexmedetomidine otomucosal gel)


You cover a lot during patient exams, and noise aversion might not be top of mind. In a survey, 88 percent of veterinarians said their clients initiate discussions about their dog’s noise aversion.2

Use these tools to open a dialogue with clients about their dog’s noise aversion.

Using SILEO at Home:

Prescribing Information (PDF)

Full Prescribing Information: indications, contraindications and more.

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Dosing Chart (PDF)

A pet owner can easily determine the appropriate dose by looking up their dog’s weight.

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Instructions for Dosing (PDF)

Before the use of a new syringe, an initial setup allows all doses to be given the same way.

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Clinic Tools:

Please contact your Zoetis representative or our Customer Service Team at 1-888-ZOETIS-1 (963-8471) for the SILEO veterinarian brochure and 13 behavior signs poster.

13 Common Signs of Noise Aversion in Dogs (video)

Learn about the 13 common signs of noise aversion in dogs video.
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How to Administer Sileo® Correctly (video)

Learn how to administer Sileo correctly video.
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Further Dosing (video)

Learn how to further dose your dog with Sileo video
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Diagnostic Checklist (PDF)

Diagnostic Checklist to determine if your dog suffers from noise aversion
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Noise Aversion & Sileo® (video)

Learn more about Noise Aversion & Sileo Video
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Noise Aversion Awareness (video)

Learn more about noise aversion awareness video.
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Client Communication:

Social Media Posts

Reach a greater audience with tips and sample posts, including fast facts, upcoming holiday preparation and behavior recognition.

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Client Email Templates

User-friendly graphics and topical content focused on upcoming holiday awareness and behavior recognition.

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Important Safety Information: Do not use SILEO in dogs with severe cardiovascular disease, respiratory, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue or in dogs hypersensitive to dexmedetomidine or to any of the excipients. SILEO should not be administered in the presence of preexisting hypotension, hypoxia, or bradycardia. Do not use in dogs sedated from previous dosing. SILEO has not been evaluated in dogs younger than 16 weeks of age or in dogs with dental or gingival disease that could have an effect on the absorption of SILEO. SILEO has not been evaluated for use in breeding, pregnant, or lactating dogs or for aversion behaviors to thunderstorms. Transient pale mucous membranes at the site of application may occur with SILEO use. Other uncommon adverse reactions included emesis, drowsiness or sedation. Handlers should avoid direct exposure of SILEO to their skin, eyes or mouth. Failure to lock the ring-stop on the syringe before dosing SILEO could potentially lead to an accidental overdose. Always review INSTRUCTIONS FOR USE before dispensing and dosing. See full Prescribing Information.


  • 2. FR Market Research – Noise Aversion; February 2016; N=472 Dog Owners, N=454 General Practitioners.



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