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Tick Protection

Simparica wipes out ticks all month long with no risky gaps in protection.

  • In well-controlled laboratory studies, Simparica chewable tablets demonstrated ≥96.9% effectiveness for 35 days against Ixodes scapularis, Amblyomma americanum, Amblyomma maculatum, Dermacentor variabilis, and Rhipicephalus sanguineus.1-3

Simparica starts killing ticks fast, reducing the likelihood of transmission of tick-borne pathogens.4

As demonstrated in a clinical study, Lyme and anaplasmosis didn’t stand a chance against Simparica. When dogs were given a single oral dose (2mg/kg), Simparica blocked the transmission of the pathogens that cause Lyme disease and anaplasmosis from deer ticks.5

Summary of Pivotal Dose Confirmation Studies Against Ticks in the United States 2,3

Simparica is for use only in dogs, 6 months of age and older. Simparica may cause abnormal neurologic signs such as tremors, decreased conscious proprioception, ataxia, decreased or absent menace, and/or seizures. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. Simparica has been safely used in dogs treated with commonly prescribed vaccines, parasiticides and other medications. The most frequently reported adverse reactions were vomiting and diarrhea. See full Prescribing Information.

1. Six RH, Geurden T, Carter L, et al. Evaluation of the speed of kill of sarolaner (Simparica) against induced infestations of three species of ticks (Amblyomma maculatum, Ixodes scapularis, Ixodes ricinus) on dogs. Vet Parasitol. 2016;222:37-42. doi:10.1016/j.vetpar.2016.02.014.
2. Zoetis. Data on file. Study Number A166C-US-15-608. Dose Confirmation of PF-06450567 Administered Orally Against Induced Infestations of Ixodes scapularis on Dogs. 2016.
3. Six RH, Everett WR, Young DR, et al. Efficacy of a novel oral formulation of sarolaner (Simparica) against five common tick species infesting dogs in the United States. Vet Parasitol. 2016;222:28-32.
4. Little SE. Changing paradigms in understanding transmission of canine tick-borne diseases: the role of interrupted feeding and intrastadial transmission. Proceedings of the 2nd Canine Vector-Borne Disease (CVBD) Symposium. April 25-28, 2007; Mazara del Vallo, Sicily, Italy.
5. Honsberger NA, Six RH, Heinz TJ, Weber A, Mahabir SP, Berg TC. Efficacy of sarolaner in the prevention of Borrelia burgdorferi and Anaplasma phagocytophilum transmission from infected Ixodes scapularis to dogs. Vet Parasitol. 2016;222:67-72. doi:10.1016/j.vetpar.2016.02.010.

This site is intended for U.S. Animal Healthcare Professionals.

The product information provided in this site is intended only for residents of the United States. The products discussed herein may not have marketing authorization or may have different product labeling in different countries. The animal health information contained herein is provided for educational purposes only and is not intended to replace discussions with an animal healthcare professional. All decisions regarding the care of a veterinary patient must be made with an animal healthcare professional, considering the unique characteristics of the patient.

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