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VANGUARD® B ORAL is the Bordetella bronchiseptica vaccine that helps provide protection by stimulating a mucosal immune response.

"We have given over 500 doses of the new VANGUARD® B Oral without any complications. The exceptional palatability and ease of administration is why it's our first choice for a Bordetella bronchiseptica vaccine."

Dr. Lowell O. Henderson,
Memorial Vet Pet Care Hospital, Houston, Texas
June 2016

Intranasal Administration

For vaccination of healthy dogs 8 weeks of age or older as an aid in preventing canine infectious tracheobronchitis (Kennel Cough) caused by Bordetella bronchiseptica.

  • Administer a single 1 mL dose orally into the buccal pouch

  • Annual revaccination with a single dose is recommended

The 1 mL dose may be administered with a syringe or a syringe-free applicator (to reduce the risk of accidental injections), providing a smooth exam room experience for veterinary staff, patients and pet owners.

Canine Infectious Respiratory Disease (CIRD)

CIRD is caused by many bacteria and viruses. Bordetella bronchiseptica is a commonly encountered bacterial pathogen in the disease complex that often leads to clinical signs of respiratory disease in dogs.

Convenient choices for vaccinating against the primary CIRD pathogen helps you PREVENT THE PREVENTABLE.

Etiology of Cird

Efficacy and Safety Studies

Efficacy Study7

Efficacy Study

Clinical Observations

Dogs were evaluated for clinical signs of respiratory disease including cough, nasal discharge, sneeze, ocular discharge, retch, depression, respiration and fever.


  • The vaccine significantly reduced coughing, p<0.0085 in comparison to the controls

  • Challenge resulted in cough in 75% of the controls, indicating challenge was successful

  • 100% of control dogs coughed in multiple (not necessarily consecutive) periods after the challenge

  • No adverse events were noted during the study

Safety Study8

Out of 321 client-owned dogs enrolled, ONE was reported to have had a brief self-limiting episode of vomiting within the 15-minute post-vaccination period.

Late Phase Post-Vaccination Period Observations



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