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VANGUARD L4 is a vaccine for healthy dogs 6 weeks of age or older to help prevent leptospirosis


VANGUARD L4 is for vaccination of healthy dogs 6 weeks of age or older as an aid in preventing leptospirosis caused by Leptospira canicola, L. grippotyphosa, L. icterohaemorrhagiae and L. pomona.

Canine leptospirosis has been increasingly reported across the United States, especially in suburban areas where dogs are coming into ever closer contact with wildlife.1

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    • VANGUARD L4 is a freeze-dried preparation of inactivated whole cell cultures of L. canicola, L. grippotyphosa, L. icterohaemorrhagiae and L. pomona.
    • Efficacy confirmed against the most common canine Leptospira serovars.
    • Microfiltered 5 times to help remove extraneous proteins, providing excellent antigen purity and smoothness.
    • Safety documented by large-scale multicenter study.
    • VANGUARD L4 is supported by our Companion Animal Immunization Support Guarantee (ISG).
  • Directions: Aseptically rehydrate the freeze-dried vaccine (Vanguard L4) with the sterile gel provided, shake well, and administer 1 mL subcutaneously or intramuscularly. Healthy dogs should receive 2 doses administered 3-4 weeks apart. Annual revaccination with a single dose is recommended.

  •  1. Stokes JE, Kaneene JB, Schall WD, et al. Prevalence of serum antibodies against six Leptospira serovars in healthy dogs. J Am Vet Med Assoc 2007;230:1657-1664.

Precautions: Store at 2°-7°C. Do not freeze. Use entire contents when first opened. Sterilized syringes and needles should be used to administer this vaccine. Vaccination of pregnant bitches should be avoided. In case of anaphylaxis, administer epinephrine or equivalent.



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