VANGUARD® Plus 5 L4 CV AIDS IN PROTECTING DOGS FROM CDV, CAV-1, CAV-2, CPV AND CPi VIRUS VANGUARD Plus 5 L4 CV is for vaccination of healthy dogs 6 weeks of age or older as an aid in preventing: Canine distemper caused by canine distemper (CD) virus. Infectious canine hepatitis caused by canine adenovirus type 1 (CAV-1). Respiratory disease caused by canine adenovirus type 2 (CAV-2). Canine parainfluenza caused by canine parainfluenza (CPiV) virus. Enteritis caused by canine coronavirus (CCV), canine parvovirus (CPV) and CPV-2c. Leptospirosis caused by Leptospira canicola, L. grippotyphosa, L. icterohaemorrhagiae and L. pomona.