Demonstrated performance of CDV, CPV, CAV-1, CAV-2, and CPiV based on retrospective serological studies.
VANGUARD Plus 5 L4 CV is a freeze-dried preparation of attenuated strains of CDV, CAV-2, CPiV, CPV, CCV and inactivated whole cell cultures of L. canicola, L. grippotyphosa, L. icterohaemorrhagiae, and L. pomona.
Leptospira cells are extensively rinsed via a proprietary diafiltration process which helps to reduce extraneous material in the vaccine.
Safety documented in a large-scale, multicenter study.
Efficacy confirmed against the common canine Leptospira serovars.
Covered by the Companion Animal Immunization Support Guarantee.
Directions: Aseptically rehydrate the freeze-dried vaccine (Vanguard Plus 5 L4) with the accompanying vial of adjuvanted liquid vaccine (Vanguard CV), shake well, and administer 1 mL subcutaneously or intramuscularly. Healthy dogs should receive 2 doses administered 3 weeks apart, followed by a single dose of Vanguard CV 3 weeks later. To avoid the potential for maternal antibody interference, dogs vaccinated at less than 9 weeks of age should receive 3 doses of the combination vaccine, each administered 3 weeks apart. Annual revaccination with a single dose is recommended.
1. Mouzin DE, Lorenzen MJ, Haworth JD, et al. Duration of serologic response to five viral antigens in dogs. J Am Vet Med Assoc 2004; 224: 55-60.
Precautions: Store at 2°-7°C. Prolonged exposure to higher temperatures and/or direct sunlight may adversely affect potency. Do not freeze. Use entire contents when first opened. Sterilized syringes and needles should be used to administer this vaccine. Do not sterilize with chemicals because traces of disinfectant may inactivate the vaccine. Burn containers and all unused contents. Contains gentamicin as preservative. Vaccination of pregnant bitches should be avoided. In case of anaphylaxis, administer epinephrine or equivalent.
Technical inquiries should be directed to Zoetis Veterinary Services, (855) 424-7349 (USA), (800) 461-0917 (Canada).
This product has been shown to be efficacious in healthy animals. A protective immune response may not be elicited if animals are incubating an infectious disease, are malnourished or parasitized, are stressed due to shipment or environmental conditions, are otherwise immunocompromised, or the vaccine is not administered in accordance with label directions.