EFFECTIVE AGAINST MULTIPLE SERIOUS THREATS TO DOGS—CDV, CAV-1, CAV-2, CPiV, CPV AND CPV-2C—AND HELPS PREVENT LEPTOSPIROSIS
VANGUARD Plus 5 L4 is for vaccination of healthy dogs 6 weeks of age or older as an aid in preventing canine distemper caused by canine distemper (CD) virus, infectious canine hepatitis (ICH) caused by canine adenovirus type 1 (CAV-1), respiratory disease caused by canine adenovirus type 2 (CAV-2), canine parainfluenza caused by canine parainfluenza CPiV, enteritis caused by canine parvovirus (CPV) and CPV-2c, and leptospirosis caused by Leptospira canicola, L. grippotyphosa, L. icterohaemorrhagiae, and L. pomona.
Demonstrated performance of the viral antigens based on retrospective serological studies.1
Vanguard Plus 5 L4 is a freeze-dried preparation of attenuated strains of CDV, CAV-2, CPiV, CPV, and inactivated whole cell cultures of L. canicola, L. grippotyphosa, L. icterohaemorrhagiae, and L. pomona.
During the manufacturing process in front of Leptospira cells are extensively rinsed, resulting in reduced extraneous materials.
Safety documented in a large-scale, multicenter study.
Efficacy confirmed against the most common canine Leptospira serovars.
Covered by the Companion Animal Immunization Support Guarantee.
Directions: Aseptically rehydrate the freeze-dried vaccine (Vanguard Plus 5 L4) with the sterile gel diluent provided, shake well, and administer 1 mL subcutaneously or intramuscularly. Healthy dogs should receive 2 doses administered 3 weeks apart. To avoid the potential for maternal antibody interference, dogs vaccinated at less than 9 weeks of age should receive 3 doses, each administered 3 weeks apart. Annual revaccination with a single dose is recommended. Duration of immunity has not been established.
1 Mouzin DE, Lorenzen MJ, Haworth, JD, et al. Duration of serologic response to five viral antigens in dogs. J Am Vet Med Assoc 2004; 224: 55-60.
Precautions: Store at 2°-7°C. Prolonged exposure to higher temperatures and/or direct sunlight may adversely affect potency. Do not freeze. Use entire contents when first opened. Sterilized syringes and needles should be used to administer this vaccine. Do not sterilize with chemicals because traces of disinfectant may inactivate the vaccine. Burn containers and all unused contents. Contains gentamicin as preservative. Vaccination of pregnant bitches should be avoided. In case of anaphylaxis, administer epinephrine or equivalent.
Technical inquiries should be directed to Zoetis Veterinary Services, (855) 424-7349 (USA), (800) 461-0917 (Canada).
This product has been shown to be efficacious in healthy animals. A protective immune response may not be elicited if animals are incubating an infectious disease, are malnourished or parasitized, are stressed due to shipment or environmental conditions, are otherwise immunocompromised, or the vaccine is not administered in accordance with label directions.