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VANGUARD® Plus 5

Helps protect against serious threats to dogs - CD virus, CAV-1, CAV-2, CPI virus, CPV and CPV-2c.

VANGUARD Plus 5 is for vaccination of healthy dogs 6 weeks of age or older as an aid in preventing canine distemper caused by canine distemper (CD) virus, infectious canine hepatitis (ICH) caused by canine adenovirus type 1 (CAV-1), respiratory disease caused by canine adenovirus type 2 (CAV-2), canine parainfluenza caused by canine parainfluenza (CPI) virus, and canine parvoviral enteritis caused by canine parvovirus (CPV) and CPV-2c.

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    • VANGUARD Plus 5 vaccines help protect puppies against diseases presenting the greatest risk of viral enteritis.
    • The CAV-2 component in VANGUARD Plus 5 vaccines cross-immunizes against CAV type 1 to help protect dogs against ICH without producing post-vaccination side effects—including persistent kidney infections, uveitis and corneal opacity (blue eye)—sometimes attributed to CAV-1 vaccines.
    • Demonstrated long-term performance of the viral antigens based on retrospective serological studies.1
    • Customer-friendly packaging includes peel-off labels to make record-keeping faster and more accurate, a color-coded organizing system, and an easy-open safety band.
    • VANGUARD Plus 5 is supported by our Companion Animal Immunization Support Guarantee (ISG).
  • Directions: Aseptically rehydrate the freeze-dried vaccine with the sterile diluent provided, shake well, and administer 1 mL subcutaneously or intramuscularly. Healthy dogs 6 weeks of age or older should receive 3 doses, each administered 3 weeks apart. Annual revaccination with a single dose is recommended. Duration of immunity has not been established.

  • 1. Mouzin DE, Lorenzen MJ, Haworth JD, et al. Duration of serologic response to five viral antigens in dogs. J Am Vet Med Assoc 2004; 224: 55-60.


Precautions: Store at 2°-7°C. Prolonged exposure to higher temperatures and/or direct sunlight may adversely affect potency. Do not freeze. Use entire contents when first opened. Sterilized syringes and needles should be used to administer this vaccine. Do not sterilize with chemicals because traces of disinfectant may inactivate the vaccine. Burn containers and all unused contents. Contains gentamicin as preservative. Vaccination of pregnant bitches should be avoided. As with many vaccines, anaphylaxis may occur after use. Initial antidote of epinephrine is recommended and should be followed with appropriate supportive therapy.

Technical inquiries should be directed to Zoetis Veterinary Services, (855) 424-7349 (USA), (800) 461-0917 (Canada).

This product has been shown to be efficacious in healthy animals. A protective immune response may not be elicited if animals are incubating an infectious disease, are malnourished or parasitized, are stressed due to shipment or environmental conditions, are otherwise immunocompromised, or the vaccine is not administered in accordance with label directions.