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According to the American Association of Equine Practitioners (AAEP), five equine diseases pose the greatest threat to your horse.1
Here’s what you should know.


Eastern Equine Encephalomyelitis

Transmitted through infected mosquitoes, the EEE virus attacks the horse’s nervous system.


Found throughout North America, rabies is a viral disease transmitted from the bite of infected animals.

Western Equine Encephalomyelitis

Transmitted through infected mosquitoes, the WEE virus attacks the horse’s nervous system.


Horses face ongoing exposure to tetanus bacteria in the soil. It is transmitted through puncture wounds, open lacerations or surgical incisions.

West Nile

West Nile is transmitted through mosquitoes. Horses with West Nile experience fever, blindness and seizures.

Vaccinate graphic


The five core equine diseases threaten every horse, everywhere. Only annual vaccination helps provide the protection your horse needs. New CORE EQ INNOVATOR™ is the first and only vaccine to protect against all core diseases in one shot.1,2

Bonnie Rush*, DVM, MS, DACVIM, dean of veterinary medicine at Kansas State University, talks about why vaccinating against the five core diseases is so important.
Buff Hildreth, DVM, shares her thoughts about dealing with a case of equine rabies at her veterinary practice in Richmond, Texas.

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  • 1 American Association of Equine Practitioners. Core Vaccination Guidelines. 2012. https://aaep.org/guidelines/vaccination-guidelines/core-vaccination-guidelines. Accessed March 1, 2018.

    2 MacKay R. Tetanus. In: Sellon DC, Long M, eds. Equine Infectious Diseases, 2nd ed. St. Louis, MO: Saunders Elsevier 2007:368-372.

    3 Ma X, Monroe BP, Cleaton JM, et al. Rabies Surveillance in the United States during 2016. JAVMA. 2018;252(8):945-957.

    4 The American Society for the Prevention of Cruelty to Animals. Pet Statistics. https://www.aspca.org/animal-homelessness/shelter-intake-and-surrender/pet-statistics. Accessed May 4, 2018.

    5 American Horse Council; Washington, DC; 2017 Economic Impact of the U.S. Horse Industry.

    6 Centers for Disease Control and Prevention. Horse Stabled at Tennessee Walking Horse 2006 National Celebration Tested Positive for Rabies. https://www.cdc.gov/rabies/resources/news/2006-09-09.html Accessed February 5, 2018.

    *Bonnie Rush, DVM, MS, DACVIM, dean of veterinary medicine, Kansas State University is a consultant to Zoetis.

    According to meta-analysis, in 2016 there were 58 rabid dogs.3 Fifty-eight cases divided by 78 million domestic dogs4 equates to approximately 0.74 rabies cases per million dogs. There were 20 rabid horses.3 Twenty cases divided by 7.2 million horses5 equates to approximately 2.8 rabies cases per million horses.