THAN THEY DELIVER.
HOW YOU VACCINATE MAY INCREASE IMMUNE RESPONSE
Ever tear open a full bag of chips, only to find more air than chips? According to research, big one-shot combination vaccines may deliver less than you expect, too. While equine vaccine combinations that include West Nile virus (WNV) with equine encephalomyelitis viruses and tetanus antigens in a single formulation may be convenient, the horse’s immunity could be what’s sacrificed. Dividing antigens into concurrent, separate injections may help increase the horse’s immune response to West Nile.1What are the Differences Between
Core and Risk Equine Vaccines?
CUSTOMIZE EQUINE VACCINATIONS TO MEET UNIQUE NEEDS
As every horse has a unique set of needs, a standard one-size-fits-all equine vaccination program does not exist. The American Association of Equine Practitioners (AAEP) Vaccination Guidelines recommend an evaluation of each individual horse’s situation and vaccinating according to his needs.2 Use the preventive health questionnaire below to make identifying each horse’s vaccination needs easier.
Dividing West Nile and equine influenza/equine herpesvirus (rhino) antigens into separate injections allows you to tailor vaccine programs. This can help provide an increased immune response to West Nile antigens. Separating antigens can allow the horse’s immune system to focus on processing the antigens while potentially reducing immune system competition.
COMBINATION VACCINES CAN CAUSE ANTIGEN INTERFERENCE
Combination vaccines can generate antigen interference due to a multitude of factors, which may inhibit the horse’s immune response. A study showed that separate administration of WEST NILE-INNOVATOR® and FLUVAC INNOVATOR® generated four times the immune response to West Nile than was produced by a big one-shot combination vaccine.1
DOING WHAT’S BEST FOR THE HORSE
Horse owners may feel that one shot is best for their horse; however, be sure to explain to your clients that the potential tradeoffs of a big one-shot combination vaccine could be a lot more important to consider than convenience.
CONVENIENCE MAY COME AT A COST
Big one-shot combination vaccines may save time, but it could be at the expense of the horse’s immune response to West Nile. A horse’s immune system supplies antigen-presenting cells to process antigens when vaccinated, allowing the horse’s immune system to trigger an effective response when presented with viremia. Administering the WEST NILE-INNOVATOR and FLUVAC INNOVATOR vaccines individually allows for the antigen-presenting cells to be most effective, therefore triggering a greater immune response to West Nile.1
REDUCE REACTIONS BY DIVIDING
If your clients are concerned about vaccination reactions, break up injections by administering different vaccines on different days.3 This will limit the number of antigens the horse will receive per visit, potentially reducing the intensity of the expected side effects.3 Also, be sure to work with the horse owner to develop a vaccination program which targets antigens the horse is truly at risk for.2,3Proper Vaccine Care
and Handling Poster
ZOETIS IS COMMITTED TO HORSE HEALTH
FLUVAC INNOVATOR and WEST NILE-INNOVATOR are the veterinarian’s first choice for core and risk equine disease protection.4 The broad portfolio of core and risk-based vaccines from Zoetis is the one both you and your clients can rely on. Zoetis continues to invest in research and development to bring you advanced vaccine solutions.
The FLUVAC INNOVATOR line of vaccines helps provide broad protection against newly emerging and conventional equine influenza viruses (EIV) as well as equine herpesvirus (EHV-1 and EHV-4).5-10 FLUVAC INNOVATOR is the most trusted risk-based disease vaccine, and regular testing helps ensure the vaccine continues to be effective against emerging EIV isolates.4-10
WEST NILE-INNOVATOR vaccines aid in the prevention of West Nile; equine encephalomyelitis due to Eastern, Western and Venezuelan viruses; and tetanus. WEST NILE-INNOVATOR is the veterinarian’s first choice for core disease protection and has been shown to provide a West Nile virus immune response that is four times stronger than a one-shot combination containing West Nile virus.1,4
METASTIM® AMPLIFIES IMMUNE RESPONSE
MetaStim® is a proprietary adjuvant system designed for safe, enhanced presentation of antigens to the horse’s immune system. MetaStim features a dual-phase formulation shown to stimulate both cell-mediated and humoral immunity.11,12 Only INNOVATOR vaccines are adjuvanted with MetaStim for improved immune responses.
Immune Response of Horses
PROVIDE PEACE OF MIND
You can offer your clients peace of mind with the Equine Immunization Support Guarantee from Zoetis, the most comprehensive guarantee available. If a horse, properly vaccinated by a veterinarian, contracts the corresponding equine disease, Zoetis will reimburse the horse owner up to $5,000 in diagnostic and treatment costs. Diseases covered by the Equine Immunization Support Guarantee include: equine rhinopneumonitis (respiratory) caused by equine herpesvirus types 1 (EHV-1) and 4 (EHV-4), West Nile, equine influenza, tetanus, Eastern equine encephalitis (EEE), Western equine encephalitis (WEE) and Venezuelan equine encephalitis (VEE).
WANT TO LEARN MORE?
To learn more about how administering core and risk antigens separately helps protect horses from disease, contact your Zoetis representative or the Zoetis Customer Service team at 1-888-963-8471.
1 Cortese V, Hankins K, Holland R, et al. Serologic responses of West Nile virus seronegative mature horses to West Nile virus vaccines. J Equine Vet Sci. 2013;33:1101-1105.
2 American Association of Equine Practitioners. Vaccination Guidelines. 2012. http://www.aaep.org/info/vaccination-guidelines. Accessed October 28, 2016.
3 Equine Chronicle. Injection Reactions. 2012. http://equinechronicleonline.com/injection-reactions/. Accessed October 28, 2016.
4 Data on file, MDI sales data for FLUVAC INNOVATOR and WEST NILE-INNOVATOR as of 12/31/15, Zoetis LLC.
5 Data on file, Study Report No. 671-02-001R, Zoetis LLC.
6 Data on file, Study Report No. 671-08-004.R, Zoetis LLC.
7 Data on file, Study Report No. 766-09-002.R, Zoetis LLC.
8 Data on file, Study Report No. 10OREQBIO-01, Zoetis LLC.
9 Data on file, Study Report No. 14OREQBIO-1, Zoetis LLC.
10 Data on file, Study Report No. 15EQRGBIO-02, Zoetis LLC.
11 Davis EG, Zhang Y, Tuttle J, et al. Investigation of antigen specific lymphocyte responses in healthy horses vaccinated with an inactivated West Nile virus vaccine. Vet Immunol Immunopathol. 2008;126(3-4):293-301.
12 Davis EG, Bello NM, Bryan AJ, et al. Characterisation of immune responses in healthy foals when a multivalent vaccine protocol was initiated at age 90 or 180 days. Equine Vet J. 2014. doi:10.1111/evj.12350.
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