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DOMOSO® GEL

(dimethyl sulfoxide)

DOMOSO (dimethyl sulfoxide) Gel is recommended as a topical application to reduce acute swelling due to trauma.

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  • Product Description:

    INDICATIONS

    DOMOSO (dimethyl sulfoxide) Gel is recommended as a topical application to reduce acute swelling due to trauma.

    Dosing and Administration:

    DOMOSO Gel (dimethyl sulfoxide) is to be administered topically to the skin over the affected area.

    Horses

    Liberal application should be administered two to three times daily. Total daily dosage should not exceed 100 g. Total duration of therapy should not exceed 30 days.

    PRECAUTION AND CONTRAINDICATIONS

    Contact between DOMOSO Gel and the skin should be avoided. Rubber gloves should be worn while applying this drug. Forceps and swabs may be used to facilitate application. If absorbed through the skin, DOMOSO Gel will cause odorous breath and unpleasant mouth taste. Mild sedation or drowsiness, sensations of warmth, burning, irritation, itching and mild erythematous localized or generalized dermatitis have been reported in some persons following exposure to DOMOSO Gel. Treatment of such side effects is symptomatic. Consult a physician immediately if adverse effects appear.

    DOMOSO Gel may mask certain disease signs such as seen in fractures, etc.; this does not obviate the need for specific therapy in such conditions.

    Since DOMOSO Gel effectively alters the biologic membrane, it will in some cases facilitate the systemic absorption of other topically applied drugs and may have a potentiating effect on drugs administered systemically.

    DOMOSO Gel should be judiciously used when administered in conjunction with other pharmaceutical preparations, especially those affecting the cardiovascular and central nervous systems.

    DOMOSO Gel may enhance the absorption of other materials into the skin. The veterinarian should make certain that other medications are not present prior to its application.

    Keep DOMOSO Gel out of the reach of children.

    DOMOSO Gel is recommended for topical application only. DO NOT ADMINISTER BY ANY OTHER ROUTE.

    DOMOSO Gel should not be used under occlusive dressings.

    DOMOSO Gel is contraindicated in horses and dogs intended for breeding purposes.

    DOMOSO Gel is a potent solvent and may have a deleterious effect on fabrics, plastics and other materials. Care should be taken to prevent physical contact with DOMOSO Gel.

    DOMOSO Gel should not be administered to horses that are to be slaughtered for food.

    CAUTION: HYGROSCOPIC. CLOSE CAP TIGHTLY AFTER USE. AVOID FREEZING. DUE TO THE RAPID PENETRATION ABILITY OF DOMOSO GEL, RUBBER GLOVES SHOULD BE WORN WHEN APPLYING THIS DRUG.

    Resources and Technical Information:

    REFERENCES:

    1. Huggins, C.E., PRESERVATION OF BLOOD FOR TRANSFUSIONS BY FREEZING WITH DIMETHYL SULFOXIDE AND A NOVEL WASHING TECHNIQUE. 1963 Surgery 54,191-194 Jul 1963
    2. Pyle, H.M. and Boyer, H.F., EFFECTS OF DIMETHYL SULFOXIDE ON BLOOD CELLS AND BONE MARROW. 1961 Vox Sang 6,199-200 1961
    3. Rowe, A.W., Kaczmarek, C.S. and Cohen, E., LOW TEMPERATURE PRESERVATION OF LEUKOCYTES IN DIMETHYL SULFOXIDE. Federation of American Societies for Experimental Biology, 47th Annual Meeting. 16-20 Apr 1963. Atlantic City 1963 Fed. Proc. 22, 170 1963 Abstr. No. 60
    4. Ashwood-Smith, M.J., LOW TEMPERATURE PRESERVATION OF MOUSE LYMPHOCYTES WITH DIMETHYL SULFOXIDE. 1964 Blood 23, 494-501 Apr 1964
    5. Djerassi, I. and Roy, A., A METHOD FOR PRESERVATION OF VIABLE PLATELETS, COMBINED EFFECTS OF SUGARS AND DIMETHYL SULFOXIDE. 1963 Blood 22, 703-717 1963
    6. Sawada, Y. and Chang, M.C., MOTILITY AND FERTILIZING CAPACITY OF RABBIT SPERMATOZOA AFTER FREEZING IN A MEDIUM CONTAINING DIMETHYL SULFOXIDE. 1964 Fertil. Steril. 15, 222-229 Mar-Apr 1964
    7. Zimmerman, S.J., Maude, M.B. and Moldawer, M., FREEZING AND STORAGE OF HUMAN SEMEN IN 50 HEALTHY MEDICAL STUDENTS. A Comparative Study of Glycerol and Dimethyl Sulfoxide as a Preservative. 1964 Fertil. Steril. 15, 505-510 Sep-Oct 1964
    8. Sherman, J.K., DIMETHYL SULFOXIDE AS A PROTECTIVE AGENT DURING FREEZING AND THAWING OF HUMAN SPERMATOZOA. 1964 Proc. Soc. Exp. Biol. Med. 177, 261-264 1964
    9. Mueller, F.O., Casey, T.A. and Trevor-Roper, P.D., USE OF DEEP-FROZEN HUMAN CORNEA IN FULL-THICKNESS GRAFTS. 1964 Brit. Med. J. No. 5407, 473-A75 22 Aug 1964
    10. Platts, S. and Reed, H., USE OF DIMETHYL SULFOXIDE FOR PRESERVING CORNEAL TISSUE. 1963 Brit. J. Ophthal. 47, 334-338 1963
    11. Barlyn, L.W., Berggren, R.B. and Lehr, H.B., FROZEN SKIN AUTOGRAFTS PROTECTED BY DIMETHYL SULFOXIDE. 1964 Surg. Forum 15, 475-476 1964
    12. Nagington, J. and Greaves, R.I., PRESERVATION OF TISSUE CULTURE CELLS WITH LIQUID NITROGEN. 1962 Nature 194, 993-994 9 Jun 1962
    13. Porterfield, J.S. and Ashwood-Smith, M.J., PRESERVATION OF CELLS IN TISSUE CULTURE BY GLYCEROL AND DIMETHYL SULFOXIDE. 1962 Nature 193, 548-550 10 Feb 1962
    14. Lovelock, J.E. and Bishop, M.W., PREVENTION OF FREEZING DAMAGE TO LIVING CELLS BY DIMETHYL SULFOXIDE. 1959 Nature 183, 1394-1395 16 May 1959
      15. Dougherty, R.M., USE OF DIMETHYL SULFOXIDE FOR PRESERVATION OF TISSUE CULTURE CELLS BY FREEZING. 1962 Nature 193, 550-552 10 Feb 1962
    15. Walker, P.J. and Ashwood-Smith, M.J., DIMETHYL SULFOXIDE, AN ALTERNATIVE TO GLYCEROL, FOR THE LOW-TEMPERATURE PRESERVATION OF TRYPANOSOMES. 1961 Ann. Trop. Med. Parasit. 55, 93-96 1961
    16. Ashwood-Smith, M.J., INABILITY OF DIMETHYL SULFOXIDE TO PROTECT MOUSE TESTIS AGAINST THE EFFECT OF X-RADIATION. 1961 Int. J. Radiat. Biol. 3, 101-103 1961
    17. Ashwood-Smith, M.J., RADIOPROTECTIVE EFFECT OF COMBINATION OF AET OR CYSTEAMINE WITH DIMETHYL SULFOXIDE. 1962 Int. J. Radiat. Biol. 5, 201-202 May 1962
    18. Leake, C.D., DIMETHYL SULFOXIDE. Science 152, 1646-1649 17 Jun 1966
    19. Sweeney, T.M., Downes, A.M. and Matoltsy, A.G., THE EFFECT OF DIMETHYL SULFOXIDE ON THE EPIDERMAL WATER BARRIER. 1966 J. Invest. Derm. 46, 300-302 Mar 1966
    20. Horita, A. and Weber, L.J., SKIN PENETRATING PROPERTY OF DRUGS DISSOLVED IN DIMETHYL SULFOXIDE, (DMSO), AND OTHER VEHICLES. 1964 Life Sci. 3, 1389-1395 Dec 1964
    21. Rosen, H., Blumenthal, A., Panasevich, R. and McCallum, J., DIMETHYL SULFOXIDE (DMSO) AS A SOLVENT IN ACUTE TOXICITY DETERMINATIONS. 1965 Proc. Soc. Exp. Biol. Med. 120, 511-514 Nov 1965
    22. Dixon, R.L., Adamson, R.H., Ben, M. and Rall, D.P., APPARENT LACK OF INTERACTION BETWEEN DIMETHYL SULFOXIDE AND A VARIETY OF DRUGS. 1965 Proc. Soc. Exp. Biol. Med. 118, 756-759 Mar 1965
    23. Rosenkrantz, H., Hadidian, Z., Seay, H. and Mason, M.M., DIMETHYL SULFOXIDE, ITS STEROID SOLUBILITY AND ENDOCRINOLOGIC AND PHARMACOLOGIC-TOXICOLOGIC CHARACTERISTICS. 1963 Cancer Chemother. Rep. No. 31, 7-24 Sep 1963
    24. Haeusler, G. and Jahn, U., UNTERSUCHUNGEN ZUR PHARMAKOLOGIE VON DIMETHYLSULFOXYD (DMSO). 1966 Arch. Int. Pharmacodyn 159, 386-400 Feb 1966
    25. Pantio, M. and Kaerki, N.T., THE INFLUENCE OF DIMETHYL SULFOXIDE ON THE ABSORPTION OF PHENYLBUTAZONE. Spanish Translation. 1965 Air 8, 133-147 1965
      27. Preziosi, P. and Scapagnini, U., ACTION OF DIMETHYL SULFOXIDE ON ACUTE INFLAMMATORY REACTIONS. 1966 Curr. Ther. Res. 8, 261-264 May 1966
    26. Katz, J., Knott, L.W. and Rubinstein, L.J., THE NEUROHISTOLOGICAL CHANGES INDUCED BY PHENOL, DIMETHYL SULFOXIDE, AND HYALURONIDASE ON THE SCIATIC NERVE OF THE RAT. Special Abstract From Fall Pharmacology Meeting April 1966
    27. Sams, W.M., Carroll, N.V. and Crantz, P.L., EFFECTS OF DIMETHYL SULFOXIDE ON ISOLATED-INNERVATED SKELETAL, SMOOTH, AND CARDIAC MUSCLE. 1966 Proc. Soc. Exp. Biol. Med. 122, 103-107 May 1966
    28. Gerhards, E., Gibian, H. and Raspe, G., STOFFWECHSEL UND STOFFWECHSELWIRKUNGEN VON DIMETHYLSULFOXID. 1965 Arzneimittelforschung 15 1295-1297 Nov 1965
    29. Mayer, J.H., Anido, H., Almond, C.H. and Seaber, A., DIMETHYL SULFOXIDE IN PREVENTION OF INTESTINAL ADHESIONS. 1965 Arch. Surg., Chicago, 91, 920-923 Dec 1965
    30. Huu, N. and Albert, H.M., EFFECT OF DMSO ON WOUND HEALING TENSILE STRENGTH MEASUREMENTS IN RABBITS. 1966 Amer. Surg. 32, 421-424 Jun 1966
    31. Wright, E.T. and Winer, L.H., TOPICAL APPLICATION OF DIMETHYL SULFOXIDE (DMSO) TO SKIN OF GUINEA PIGS, A Histopathological Study. 1966 J. Invest. Derm. 46, 409-414 Apr 1966
    32. Willoughby, D.A., Walters, M.N. and Spector, W.G., AN ANALYSIS OF THE IRRITANT ACTION OF DIMETHYL SULFOXIDE. 1966 J. Path. Bact. 91, 195-205 Jan 1966
    33. Marin-Padilla, M., MESODERMAL ALTERATIONS INDUCED BY DIMETHYL SULFOXIDE. 1966 Proc. Soc. Exp. Biol. Med. 122, 717-720 Jul 1966
    34. Caujolle, F., Caujolle, D., Cros. S., Calvert, M. and Tollon, Y., TERATOGENESE POUVOIR TERATOGENE DU DIMETHYLSULFOXIDE ET DU DIETHYLSULFOXYDE. TERATOGENESIS-TESTS OF THE TERATOGENY OF DIMETHYL SULFOXIDE AND OF DIETHYL SULFOXIDE. 1965 C.R. Acad. Sci. Paris, 260, 327-330 4 Jan 1965
    35. Rubin, L.F. and Mattis, P.A., DIMETHYL SULFOXIDE, LENS CHANGES IN DOGS DURING ORAL ADMINISTRATION. 1966 Science 153,83-84 1 Jul 1966
    36. Unpublished data 1966
    37. DiStefano, V. and Klahn, J.J., OBSERVATIONS ON THE PHARMACOLOGY AND HEMOLYTIC ACTIVITY OF DIMETHYL SULFOXIDE. 1965 Toxic. Appl. Pharmacol. 7, 660-666 Sep 1965
    38. Sommer, S. and Tauberger, G., TOXIKOLOGISCHE UNTERSUCHUNGEN MIT DIMETHYLSULFOXYD. TOXICOLOGIC INVESTIGATIONS WITH DIMETHYL SULFOXIDE. 1964 Arzneimittelforschung 14, 1050-1053 1964
    39. Jacob, S.W., Herschler, R.J. and Rosenbaum, E.E., DIMETHYL SULFOXIDE (DMSO) LABORATORY AND CLINICAL EVALUATION. 1965 J. Amer. Vet. Med. Assoc. 147, 1350-1359 1965
    40. Brown, V.K., Robinson, J. and Stevenson, D.E., A NOTE ON THE TOXICITY AND SOLVENT PROPERTIES OF DIMETHYL SULFOXIDE. 1963 J. Pharm. Pharmacol. 15, 688-692 Oct 1963
    41. Willson, J.E., Brown, D.E. and Timmens, E.K., A TOXICOLOGIC STUDY OF DIMETHYL SULFOXIDE. 1965 Toxic. Appl. Pharmacol. 7, 104-112 Jan 1965
    42. Caujolle, F., Caujolle, D., Bouyssou, H. and Calvert, M.M., PHARMACODYNAMIE-TOXICITE ET APTITUDES PHARMACOLOGIQUES DU DIMETHYLSULFOXYDE. PHARMACODYNAMICS-TOXICITY AND PHARMACOLOGICAL PROPERTIES OF DIMETHYL SULFOXIDE. 1964 C.R. Acad. Sci. Paris, 258, 2224-2226 17 Feb 1964
  • Product Description:

    INDICATIONS

    Canine and Equine

    DOMOSO (dimethyl sulfoxide) Gel is recommended as a topical application to reduce acute swelling due to trauma.

    Dosing and Administration:

    DOMOSO Gel (dimethyl sulfoxide) is to be administered topically to the skin over the affected area.

    Dogs -  Liberal application should be administered three to four times daily. Total daily dosage should not exceed 20 g. Total duration of therapy should not exceed 14 days.

    PRECAUTION AND CONTRAINDICATIONS

    Contact between DOMOSO Gel and the skin should be avoided. Rubber gloves should be worn while applying this drug. Forceps and swabs may be used to facilitate application. If absorbed through the skin, DOMOSO Gel will cause odorous breath and unpleasant mouth taste. Mild sedation or drowsiness, sensations of warmth, burning, irritation, itching and mild erythematous localized or generalized dermatitis have been reported in some persons following exposure to DOMOSO Gel. Treatment of such side effects is symptomatic. Consult a physician immediately if adverse effects appear.

    DOMOSO Gel may mask certain disease signs such as seen in fractures, etc.; this does not obviate the need for specific therapy in such conditions.

    Since DOMOSO Gel effectively alters the biologic membrane, it will in some cases facilitate the systemic absorption of other topically applied drugs and may have a potentiating effect on drugs administered systemically.

    DOMOSO Gel should be judiciously used when administered in conjunction with other pharmaceutical preparations, especially those affecting the cardiovascular and central nervous systems.

    DOMOSO Gel may enhance the absorption of other materials into the skin. The veterinarian should make certain that other medications are not present prior to its application.

    Keep DOMOSO Gel out of the reach of children.

    DOMOSO Gel is recommended for topical application only. DO NOT ADMINISTER BY ANY OTHER ROUTE.

    DOMOSO Gel should not be used under occlusive dressings.

    DOMOSO Gel is contraindicated in horses and dogs intended for breeding purposes.

    DOMOSO Gel is a potent solvent and may have a deleterious effect on fabrics, plastics and other materials. Care should be taken to prevent physical contact with DOMOSO Gel.

    DOMOSO Gel should not be administered to horses that are to be slaughtered for food.

    CAUTION: HYGROSCOPIC. CLOSE CAP TIGHTLY AFTER USE. AVOID FREEZING. DUE TO THE RAPID PENETRATION ABILITY OF DOMOSO GEL, RUBBER GLOVES SHOULD BE WORN WHEN APPLYING THIS DRUG.

    Resources and Technical Information:

    REFERENCES:

    1. Huggins, C.E., PRESERVATION OF BLOOD FOR TRANSFUSIONS BY FREEZING WITH DIMETHYL SULFOXIDE AND A NOVEL WASHING TECHNIQUE. 1963 Surgery 54,191-194 Jul 1963
    2. Pyle, H.M. and Boyer, H.F., EFFECTS OF DIMETHYL SULFOXIDE ON BLOOD CELLS AND BONE MARROW. 1961 Vox Sang 6,199-200 1961
    3. Rowe, A.W., Kaczmarek, C.S. and Cohen, E., LOW TEMPERATURE PRESERVATION OF LEUKOCYTES IN DIMETHYL SULFOXIDE. Federation of American Societies for Experimental Biology, 47th Annual Meeting. 16-20 Apr 1963. Atlantic City 1963 Fed. Proc. 22, 170 1963 Abstr. No. 60
    4. Ashwood-Smith, M.J., LOW TEMPERATURE PRESERVATION OF MOUSE LYMPHOCYTES WITH DIMETHYL SULFOXIDE. 1964 Blood 23, 494-501 Apr 1964
    5. Djerassi, I. and Roy, A., A METHOD FOR PRESERVATION OF VIABLE PLATELETS, COMBINED EFFECTS OF SUGARS AND DIMETHYL SULFOXIDE. 1963 Blood 22, 703-717 1963
    6. Sawada, Y. and Chang, M.C., MOTILITY AND FERTILIZING CAPACITY OF RABBIT SPERMATOZOA AFTER FREEZING IN A MEDIUM CONTAINING DIMETHYL SULFOXIDE. 1964 Fertil. Steril. 15, 222-229 Mar-Apr 1964
    7. Zimmerman, S.J., Maude, M.B. and Moldawer, M., FREEZING AND STORAGE OF HUMAN SEMEN IN 50 HEALTHY MEDICAL STUDENTS. A Comparative Study of Glycerol and Dimethyl Sulfoxide as a Preservative. 1964 Fertil. Steril. 15, 505-510 Sep-Oct 1964
    8. Sherman, J.K., DIMETHYL SULFOXIDE AS A PROTECTIVE AGENT DURING FREEZING AND THAWING OF HUMAN SPERMATOZOA. 1964 Proc. Soc. Exp. Biol. Med. 177, 261-264 1964
    9. Mueller, F.O., Casey, T.A. and Trevor-Roper, P.D., USE OF DEEP-FROZEN HUMAN CORNEA IN FULL-THICKNESS GRAFTS. 1964 Brit. Med. J. No. 5407, 473-A75 22 Aug 1964
    10. Platts, S. and Reed, H., USE OF DIMETHYL SULFOXIDE FOR PRESERVING CORNEAL TISSUE. 1963 Brit. J. Ophthal. 47, 334-338 1963
    11. Barlyn, L.W., Berggren, R.B. and Lehr, H.B., FROZEN SKIN AUTOGRAFTS PROTECTED BY DIMETHYL SULFOXIDE. 1964 Surg. Forum 15, 475-476 1964
    12. Nagington, J. and Greaves, R.I., PRESERVATION OF TISSUE CULTURE CELLS WITH LIQUID NITROGEN. 1962 Nature 194, 993-994 9 Jun 1962
    13. Porterfield, J.S. and Ashwood-Smith, M.J., PRESERVATION OF CELLS IN TISSUE CULTURE BY GLYCEROL AND DIMETHYL SULFOXIDE. 1962 Nature 193, 548-550 10 Feb 1962
    14. Lovelock, J.E. and Bishop, M.W., PREVENTION OF FREEZING DAMAGE TO LIVING CELLS BY DIMETHYL SULFOXIDE. 1959 Nature 183, 1394-1395 16 May 1959
    15. Dougherty, R.M., USE OF DIMETHYL SULFOXIDE FOR PRESERVATION OF TISSUE CULTURE CELLS BY FREEZING. 1962 Nature 193, 550-552 10 Feb 1962
    16. Walker, P.J. and Ashwood-Smith, M.J., DIMETHYL SULFOXIDE, AN ALTERNATIVE TO GLYCEROL, FOR THE LOW-TEMPERATURE PRESERVATION OF TRYPANOSOMES. 1961 Ann. Trop. Med. Parasit. 55, 93-96 1961
    17. Ashwood-Smith, M.J., INABILITY OF DIMETHYL SULFOXIDE TO PROTECT MOUSE TESTIS AGAINST THE EFFECT OF X-RADIATION. 1961 Int. J. Radiat. Biol. 3, 101-103 1961
    18. Ashwood-Smith, M.J., RADIOPROTECTIVE EFFECT OF COMBINATION OF AET OR CYSTEAMINE WITH DIMETHYL SULFOXIDE. 1962 Int. J. Radiat. Biol. 5, 201-202 May 1962
    19. Leake, C.D., DIMETHYL SULFOXIDE. Science 152, 1646-1649 17 Jun 1966
    20. Sweeney, T.M., Downes, A.M. and Matoltsy, A.G., THE EFFECT OF DIMETHYL SULFOXIDE ON THE EPIDERMAL WATER BARRIER. 1966 J. Invest. Derm. 46, 300-302 Mar 1966
    21. Horita, A. and Weber, L.J., SKIN PENETRATING PROPERTY OF DRUGS DISSOLVED IN DIMETHYL SULFOXIDE, (DMSO), AND OTHER VEHICLES. 1964 Life Sci. 3, 1389-1395 Dec 1964
    22. Rosen, H., Blumenthal, A., Panasevich, R. and McCallum, J., DIMETHYL SULFOXIDE (DMSO) AS A SOLVENT IN ACUTE TOXICITY DETERMINATIONS. 1965 Proc. Soc. Exp. Biol. Med. 120, 511-514 Nov 1965
    23. Dixon, R.L., Adamson, R.H., Ben, M. and Rall, D.P., APPARENT LACK OF INTERACTION BETWEEN DIMETHYL SULFOXIDE AND A VARIETY OF DRUGS. 1965 Proc. Soc. Exp. Biol. Med. 118, 756-759 Mar 1965
    24. Rosenkrantz, H., Hadidian, Z., Seay, H. and Mason, M.M., DIMETHYL SULFOXIDE, ITS STEROID SOLUBILITY AND ENDOCRINOLOGIC AND PHARMACOLOGIC-TOXICOLOGIC CHARACTERISTICS. 1963 Cancer Chemother. Rep. No. 31, 7-24 Sep 1963
    25. Haeusler, G. and Jahn, U., UNTERSUCHUNGEN ZUR PHARMAKOLOGIE VON DIMETHYLSULFOXYD (DMSO). 1966 Arch. Int. Pharmacodyn 159, 386-400 Feb 1966
    26. Pantio, M. and Kaerki, N.T., THE INFLUENCE OF DIMETHYL SULFOXIDE ON THE ABSORPTION OF PHENYLBUTAZONE. Spanish Translation. 1965 Air 8, 133-147 1965
    27. Preziosi, P. and Scapagnini, U., ACTION OF DIMETHYL SULFOXIDE ON ACUTE INFLAMMATORY REACTIONS. 1966 Curr. Ther. Res. 8, 261-264 May 1966
    28. Katz, J., Knott, L.W. and Rubinstein, L.J., THE NEUROHISTOLOGICAL CHANGES INDUCED BY PHENOL, DIMETHYL SULFOXIDE, AND HYALURONIDASE ON THE SCIATIC NERVE OF THE RAT. Special Abstract From Fall Pharmacology Meeting April 1966
    29. Sams, W.M., Carroll, N.V. and Crantz, P.L., EFFECTS OF DIMETHYL SULFOXIDE ON ISOLATED-INNERVATED SKELETAL, SMOOTH, AND CARDIAC MUSCLE. 1966 Proc. Soc. Exp. Biol. Med. 122, 103-107 May 1966
    30. Gerhards, E., Gibian, H. and Raspe, G., STOFFWECHSEL UND STOFFWECHSELWIRKUNGEN VON DIMETHYLSULFOXID. 1965 Arzneimittelforschung 15 1295-1297 Nov 1965
    31. Mayer, J.H., Anido, H., Almond, C.H. and Seaber, A., DIMETHYL SULFOXIDE IN PREVENTION OF INTESTINAL ADHESIONS. 1965 Arch. Surg., Chicago, 91, 920-923 Dec 1965
    32. Huu, N. and Albert, H.M., EFFECT OF DMSO ON WOUND HEALING TENSILE STRENGTH MEASUREMENTS IN RABBITS. 1966 Amer. Surg. 32, 421-424 Jun 1966
    33. Wright, E.T. and Winer, L.H., TOPICAL APPLICATION OF DIMETHYL SULFOXIDE (DMSO) TO SKIN OF GUINEA PIGS, A Histopathological Study. 1966 J. Invest. Derm. 46, 409-414 Apr 1966
    34. Willoughby, D.A., Walters, M.N. and Spector, W.G., AN ANALYSIS OF THE IRRITANT ACTION OF DIMETHYL SULFOXIDE. 1966 J. Path. Bact. 91, 195-205 Jan 1966
    35. Marin-Padilla, M., MESODERMAL ALTERATIONS INDUCED BY DIMETHYL SULFOXIDE. 1966 Proc. Soc. Exp. Biol. Med. 122, 717-720 Jul 1966
    36. Caujolle, F., Caujolle, D., Cros. S., Calvert, M. and Tollon, Y., TERATOGENESE POUVOIR TERATOGENE DU DIMETHYLSULFOXIDE ET DU DIETHYLSULFOXYDE. TERATOGENESIS-TESTS OF THE TERATOGENY OF DIMETHYL SULFOXIDE AND OF DIETHYL SULFOXIDE. 1965 C.R. Acad. Sci. Paris, 260, 327-330 4 Jan 1965
    37. Rubin, L.F. and Mattis, P.A., DIMETHYL SULFOXIDE, LENS CHANGES IN DOGS DURING ORAL ADMINISTRATION. 1966 Science 153,83-84 1 Jul 1966
    38. Unpublished data 1966
    39. DiStefano, V. and Klahn, J.J., OBSERVATIONS ON THE PHARMACOLOGY AND HEMOLYTIC ACTIVITY OF DIMETHYL SULFOXIDE. 1965 Toxic. Appl. Pharmacol. 7, 660-666 Sep 1965
    40. Sommer, S. and Tauberger, G., TOXIKOLOGISCHE UNTERSUCHUNGEN MIT DIMETHYLSULFOXYD. TOXICOLOGIC INVESTIGATIONS WITH DIMETHYL SULFOXIDE. 1964 Arzneimittelforschung 14, 1050-1053 1964
    41. Jacob, S.W., Herschler, R.J. and Rosenbaum, E.E., DIMETHYL SULFOXIDE (DMSO) LABORATORY AND CLINICAL EVALUATION. 1965 J. Amer. Vet. Med. Assoc. 147, 1350-1359 1965
    42. Brown, V.K., Robinson, J. and Stevenson, D.E., A NOTE ON THE TOXICITY AND SOLVENT PROPERTIES OF DIMETHYL SULFOXIDE. 1963 J. Pharm. Pharmacol. 15, 688-692 Oct 1963
    43. Willson, J.E., Brown, D.E. and Timmens, E.K., A TOXICOLOGIC STUDY OF DIMETHYL SULFOXIDE. 1965 Toxic. Appl. Pharmacol. 7, 104-112 Jan 1965
    44. Caujolle, F., Caujolle, D., Bouyssou, H. and Calvert, M.M., PHARMACODYNAMIE-TOXICITE ET APTITUDES PHARMACOLOGIQUES DU DIMETHYLSULFOXYDE. PHARMACODYNAMICS-TOXICITY AND PHARMACOLOGICAL PROPERTIES OF DIMETHYL SULFOXIDE. 1964 C.R. Acad. Sci. Paris, 258, 2224-2226 17 Feb 1964

IMPORTANT SAFETY INFORMATION

Avoid contact of DOMOSO GEL with skin and eyes. Use gloves and apply in a well ventilated area. For topical use only. Do not use in conditions of physical stress or activity where this product could mask existing pathology. Use caution when applying other topical drugs, and in conjunction with other pharmaceutical preparations, especially those affecting the cardiovascular and central nervous systems. .
 

For more safety information, please refer to the full Prescribing Information.