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DOMOSO® SOLUTION

(dimethyl sulfoxide)

DOMOSO (dimethyl sulfoxide) Solution is recommended as a topical application to reduce acute swelling due to trauma.

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  • Product description:

    Indications:

    DOMOSO (dimethyl sulfoxide) Solution is recommended as a topical application to reduce acute swelling due to trauma.

    Dosing and Administration:

    DOMOSO Solution is to be administered topically to the skin over the affected area. The spray pump should be initially held approximately 6 inches from the animal and the distance adjusted to provide a uniform coverage of the area. The volume delivered by depressing the spray pump is approximately 1/3 mL. Refer to user precautions below under

    Horses

    Liberal application should be administered two to three times daily. Total daily dosage should not exceed 100 mL. Total duration of therapy should not exceed 30 days.

    PRECAUTIONS AND CONTRAINDICATIONS

    Contact between DOMOSO Solution and the skin should be avoided. Rubber gloves should be worn while applying this drug. Forceps and swabs may be used to facilitate application. If absorbed through the skin, DOMOSO Solution will cause odorous breath and unpleasant mouth taste. Mild sedation or drowsiness, sensations of warmth, burning, irritation, itching and mild erythematous localized or generalized dermatitis have been reported in some persons following exposure to DOMOSO Solution. Treatment of such side effects is symptomatic. Consult a physician immediately if adverse effects appear.

    DOMOSO Solution may mask certain disease signs such as are seen in fractures etc.; this does not obviate the need for specific therapy in such conditions. DOMOSO should not be used directly prior to racing or other physical stress wherein the drug might mask existing pathology, such as a fracture.

    Since DOMOSO Solution effectively alters the biologic membrane, it will in some cases facilitate the systemic absorption of other topically applied drugs and may have a potentiating effect on drugs administered systemically. Therefore, great care should be exercised in use of other drugs at the DOMOSO Solution application site because of the demonstrated - if variable - ability of DMSO to carry other chemicals through the dermis into the general circulation. If other topical medications are indicated they should not be applied until DOMOSO Solution is thoroughly dry. Frequently, due to the heat of resolution, a “smoking” effect following application is noted due to vaporization of the drug.

    DOMOSO Solution should also be judiciously used when administered in conjunction with other pharmaceutical preparations, especially those affecting the cardiovascular and central nervous systems. DMSO may potentiate the activity of atropine, insulin, endogenous steroids and certain other drugs.

    Lowering of the vagal threshold, spontaneous skeletal muscle fasciculation, and increased smooth muscle tone in the stomach following DMSO exposure may be due to cholinesterase inhibition. Therefore, DOMOSO Solution should not be used on dogs, or horses, simultaneously or within a few days before or after treatment with, or exposure to, cholinesterase-inhibiting pesticides or drugs.

    DOMOSO SOLUTION IS RECOMMENDED FOR TOPICAL APPLICATION ONLY. THE APPLICATION OF DOMOSO SOLUTION SHOULD TAKE PLACE ONLY IN WELL VENTILATED QUARTERS. INHALATION OF THE DRUG SHOULD BE AVOIDED. AVOID CONTACT OF THE MEDICATION WITH THE EYES.

    Keep DOMOSO Solution out of the reach of children.

    DO NOT ADMINISTER BY ANY OTHER ROUTE.

    DOMOSO Solution should not be used under occlusive dressings. DOMOSO Solution is contraindicated in horses and dogs intended for breeding purposes.

    DOMOSO Solution is a potent solvent and may have a deleterious effect on fabrics, plastics and other materials. Care should be taken to prevent physical contact with DOMOSO Solution and these materials, either alone or until drying of the treated skin surface has occurred when applied to an animal.

    CAUTION: EXTREMELY HYGROSCOPIC! CLOSE BOTTLE CAP TIGHTLY AFTER USE. AVOID FREEZING. DUE TO THE RAPID PENETRATION ABILITY OF DOMOSO, RUBBER GLOVES SHOULD BE WORN WHEN APPLYING THIS DRUG.

    Resources and Technical Information:

    REFERENCES:

    1. Kolb, K.H., Janicke, G., Kramer, M., Schulze, P.E. and Raspe, G., DAS VERHALTEN VON 35S MARKIERTEM DIMETHYLSULFOXID IM MENSCHLICHEN UND TIERISCHEN ORGANISMUS. 1965 Arzneimittel-forschung 15 1292-1295 Nov 1965
    2. Gerhands, E., Gibian, H. and Raspe, G., STOFFWECHSEL UND STOFFWECHSELWIRKUNGEN VON DIMETHYLSULFOXID. 1965 Arzeneimittel-forschung 15 1295-1297 Nov 1965
    3. Hucker, H.B., Ahmad, P.M. and Miller, E.A., PHYSIOLOGICAL DISPOSITION AND METABOLISM OF DIMETHYL SULFOXIDE, DMSO. Federation of American Societies for Experimental Biology, 49th Annual Meeting. 9-14 Apr 1965, Atlantic City. 1965 Fed. Proc. 24, 546 Mar-Apr 1965, Abstr. No. 2310
    4. DiStefano, V. and Borgstedt, H.H., REDUCTION OF DIMETHYL SULFOXIDE TO DIMETHYL SULFIDE IN THE CAT. 1964 Science 144, 1137-1138 29 May 1964
    5. Williams, K.I., Whittemore, K.S., Mellin, T.N. and Layne, D.S., OXIDATION OF DIMETHYL SULFOXIDE TO DIMETHYL SULFONE IN THE RABBIT. 1965 Science 149, 203-204 9 Jul 1965
    6. Williams, K.E., Burstein, S.H. and Layne, D.S., DIMETHYL SULFONE, ISOLATION FROM COWS MILK. 1966 Proc. Soc. Exp. Biol. Med. 122, 865-866 Jul 1966
    7. Huggins, C.E., PRESERVATION OF BLOOD FOR TRANSFUSIONS BY FREEZING WITH DIMETHYL SULFOXIDE AND A NOVEL WASHING TECHNIQUE. 1963 Surgery 54, 191-194 Jul 1963
    8. Pyle, H.M. and Boyer, H.F., EFFECTS OF DIMETHYL SULFOXIDE ON BLOOD CELLS AND BONE MARROW. 1961 Vox Sang 6, 199-200 1961
    9. Rowe, A.W., Kaczmarek, C.S. and Cohen, E., LOW TEMPERATURE PRESERVATION OF LEUKOCYTES IN DIMETHYL SULFOXIDE. Federation of American Societies for Experimental Biology, 47th Annual Meeting. 16-20 Apr 1963. Atlantic City 1963 Fed. Proc. 22, 170 1963 Abstr. No. 60
    10. Ashwood-Smith, M.J., LOW TEMPERATURE PRESERVATION OF MOUSE LYMPHOCYTES WITH DIMETHYL SULFOXIDE. 1964 Blood 23, 494-501 Apr 1964
    11. Djerassi, I. and Roy, A., A METHOD FOR PRESERVATION OF VIABLE PLATELETS, COMBINED EFFECTS OF SUGARS AND DIMETHYL SULFOXIDE. 1963 Blood 22, 703-717 1963
    12. Sawada, Y. and Chang, M.C., MOTILITY AND FERTILIZING CAPACITY OF RABBIT SPERMATOZOA AFTER FREEZING IN A MEDIUM CONTAINING DIMETHYL SULFOXIDE. 1964 Fertil. Steril. 15, 222-229 Mar-Apr 1964
    13. Zimmerman, S.J., Maude, M.B. and Moldawer, M., FREEZING AND STORAGE OF HUMAN SEMEN IN 50 HEALTHY MEDICAL STUDENTS. A Comparative Study of Glycerol and Dimethyl Sulfoxide as a Preservative. 1964 Fertil. Steril. 15, 505-510 Sep-Oct 1964
    14. Sherman, J.K., DIMETHYL SULFOXIDE AS A PROTECTIVE AGENT DURING FREEZING AND THAWING OF HUMAN SPERMATOZOA. 1964 Proc. Soc. Exp. Biol. Med. 177, 261-264 1964
    15. Mueller, F.O., Casey, T.A. and Trevor-Roper, P.D., USE OF DEEP-FROZEN HUMAN CORNEA IN FULL-THICKNESS GRAFTS. 1964 Brit. Med. J. No. 5407, 473-475 22 Aug 1964
    16. Platts, S. and Reed, H., USE OF DIMETHYL SULFOXIDE FOR PRESERVING CORNEAL TISSUE. 1963 Brit. J. Ophthal. 47, 334-338 1963
    17. Barlyn, L.W., Berggren, R.B. and Lehr, H.B., FROZEN SKIN AUTOGRAFTS PROTECTED BY DIMETHYL SULFOXIDE. 1964 Surg. Forum 15, 475-476 1964
    18. Nagington, J. and Greaves, R.I., PRESERVATION OF TISSUE CULTURE CELLS WITH LIQUID NITROGEN. 1962 Nature 194, 993-994 9 Jun 1962
    19. Porterfield, J.S. and Ashwood-Smith, M.J., PRESERVATION OF CELLS IN TISSUE CULTURE BY GLYCEROL AND DIMETHYL SULFOXIDE. 1962 Nature 193, 548-550 10 Feb 1962
    20. Lovelock, J.E. and Bishop, M.W., PREVENTION OF FREEZING DAMAGE TO LIVING CELLS BY DIMETHYL SULFOXIDE. 1959 Nature 183, 1394-1395 16 May 1959
    21. Dougherty, R.M., USE OF DIMETHYL SULFOXIDE FOR PRESERVATION OF TISSUE CULTURE CELLS BY FREEZING. 1962 Nature 193, 550-552 10 Feb 1962
    22. Walker, P.J. and Ashwood-Smith, M.J., DIMETHYL SULFOXIDE, AN ALTERNATIVE TO GLYCEROL, FOR THE LOW-TEMPERATURE PRESERVATION OF TRYPANOSOMES. 1961 Ann. Trop. Med. Parasit. 55, 93-96 1961
    23. Ashwood-Smith, M.J., INABILITY OF DIMETHYL SULFOXIDE TO PROTECT MOUSE TESTIS AGAINST THE EFFECT OF X-RADIATION. 1961 Int. J. Radiat. Biol. 3, 101-103 1961
    24. Ashwood-Smith, M.J., RADIOPROTECTIVE EFFECT OF COMBINATION OF AET OR CYSTEAMINE WITH DIMETHYL SULFOXIDE. 1962 Int. J. Radiat. Biol. 5, 201-202 May 1962
    25. Jacob, S.W., Bischel, M. and Herschler, R.J., DIMETHYL SULFOXIDE, EFFECTS ON THE PERMEABILITY OF BIOLOGIC MEMBRANES. Preliminary Report. 1964 Curr. Ther. Res. 6, 193-198 Mar 1964
    26. Jacob, S.W., Bischel, M.D., Eberle, G.A. and Herschler, R.J., THE INFLUENCE OF DIMETHYL SULFOXIDE ON THE TRANSPORT OF INSULIN ACROSS A BIOLOGIC MEMBRANE. Federation of American Societies for Experimental Biology, 48th Annual Meeting. 12-17 Apr 1964 Chicago. 1964 Fed. Proc. 23, 410 Mar-Apr 1964 Abstr. No. 1850
    27. Stoughton, R.B. and Fritsch, W., INFLUENCE OF DIMETHYL SULFOXIDE (DMSO) ON HUMAN PERCUTANEOUS ABSORPTION. Archives of Dermatology 90:512 Nov 1964
    28. Kligman, A.M., TOPICAL PHARMACOLOGY AND TOXICOLOGY OF DIMETHYL SULFOXIDE - PART I. 1965 J. Amer. Med. Assoc. 193, 796-804 6 Sep 1965
    29. Kligman, A.M., TOPICAL PHARMACOLOGY AND TOXICOLOGY OF DIMETHYL SULFOXIDE - PART II. 1965 J. Amer. Med. Assoc. 193, 923-928 13 Sep 1965
    30. Leake, C.D., DIMETHYL SULFOXIDE. Science 152, 1646-1649 17 Jun 1966
    31. Sweeney, T.M., Downes, A.M. and Matoltsy, A.G., THE EFFECT OF DIMETHYL SULFOXIDE ON THE EPIDERMAL WATER BARRIER. 1966 J. Invest. Derm. 46, 300-302 Mar 1966
    32. Horita, A. and Weber, L.J., SKIN PENETRATING PROPERTY OF DRUGS DISSOLVED IN DIMETHYL SULFOXIDE, DMSO, AND OTHER VEHICLES. 1964 Life Sci. 3, 1389-1395 Dec 1964
    33. Rosen, H., Blumenthal, A., Panasevich, R. and McCallum, J., DIMETHYL SULFOXIDE (DMSO) AS A SOLVENT IN ACUTE TOXICITY DETERMINATIONS. 1965 Proc. Soc. Exp. Biol. Med. 120, 511-514 Nov 1965
    34. Dixon, R.L., Adamson, R.H., Ben, M. and Rall, D.P., APPARENT LACK OF INTERACTION BETWEEN DIMETHYL SULFOXIDE AND A VARIETY OF DRUGS. 1965 Proc. Soc. Exp. Biol. Med. 118, 756-759 Mar 1965
    35. Rosenkrantz, H., Hadidian, Z., Seay, H. and Mason, M.M., DIMETHYL SULFOXIDE, ITS STEROID SOLUBILITY AND ENDOCRINOLOGIC AND PHARMACOLOGIC-TOXICOLOGIC CHARACTERISTICS. 1963 Cancer Chemother. Rep. No. 31, 7-24 Sep 1963
    36. Haeusler, G. and Jahn, U., UNTERSUCHUNGEN ZUR PHARMAKOLOGIE VON DIMETHYLSULFOXYD (DMSO). 1966 Arch. Int. Pharmacodyn 159, 386-400 Feb 1966
    37. Pantio, M. and Kaerki, N.T., THE INFLUENCE OF DIMETHYL SULFOXIDE ON THE ABSORPTION OF PHENYLBUTAZONE. Spanish Translation. 1965 Air 8, 133-147 1965
    38. Block, L.H., DMSO. MEDICINAL AND PHARMACEUTICAL ASPECTS. 1964 Drug Cosmet. Industr. 95, 342-346, 462-464 Sep 1964
    39. Jacob, S.W., Herschler, R.J. and Rosenbaum, E.E., DIMETHYL SULFOXIDE (DMSO) LABORATORY AND CLINICAL EVALUATION. 1965 J. Amer. Vet. Med. Assoc. 147, 1350-1359 1965
    40. Preziosi, P. and Scapagnini, U., ACTION OF DIMETHYL SULFOXIDE ON ACUTE INFLAMMATORY REACTIONS. 1966 Curr. Ther. Res. 8, 261-264 May 1966
    41. Katz, J., Knott, L.W. and Rubinstein, L.J., THE NEUROHISTOLOGICAL CHANGES INDUCED BY PHENOL, DIMETHYL SULFOXIDE, AND HYALURONIDASE ON THE SCIATIC NERVE OF THE RAT. Special Abstract From Fall Pharmacology Meeting April 1966
    42. Pope, D.C. and Oliver, W.T., DIMETHYL SULFOXIDE (DMSO). 1966 Canad. J. Comp. Med. 30, 3-8 Jan 1966
    43. Sams, W.M., Carroll, N.V. and Crantz, P.L., EFFECTS OF DIMETHYL SULFOXIDE ON ISOLATED-INNERVATED SKELETAL, SMOOTH, AND CARDIAC MUSCLE. 1966 Proc. Soc. Exp. Biol. Med. 122, 103-107 May 1966
    44. DiStefano, V. and Klahn, J.J., OBSERVATIONS ON THE PHARMACOLOGY AND HEMOLYTIC ACTIVITY OF DIMETHYL SULFOXIDE. 1965 Toxic. Appl. Pharmacol. 7, 660-666 Sep 1965
    45. Mayer, J.H., Anido, H., Almond, C.H. and Seaber, A., DIMETHYL SULFOXIDE IN PREVENTION OF INTESTINAL ADHESIONS. 1965 Arch. Surg., Chicago, 91, 920-923 Dec 1965
    46. Huu, N. and Albert, H.M., EFFECT OF DMSO ON WOUND HEALING TENSILE STRENGTH MEASUREMENTS IN RABBITS. 1966 Amer. Surg. 32, 421-424 Jun 1966
    47. Scherbel, A.L., McCormack, L.J. and Poppo, M.J., ALTERATION OF COLLAGEN IN GENERALIZED SCLERODERMA (PROGRESSIVE SYSTEMIC SCLEROSIS) AFTER TREATMENT WITH DIMETHYL SULFOXIDE. 1965 Cleveland Clin. Quart. 32, 47-56 Apr 1965
    48. Jacob, S.W., Bischel, M. and Herschler, R.J., DIMETHYL SULFOXIDE, DMSO: A NEW CONCEPT IN PHARMACOTHERAPY. 1964 Curr. Ther. Res. 6, 134-135 Feb 1964
    49. Krizek, T.J. and Davis, J.H., BACTERIOSTATIC QUALITIES OF DIMETHYL SULFOXIDE. American Federation for Clinical Research, Annual Meeting of the Midwestern Section, 5 Nov 1964, Chicago. 1964 Clin. Res. 21, 349 1964 Abstr.
    50. Wright, E.T. and Winer, L.H., TOPICAL APPLICATION OF DIMETHYL SULFOXIDE (DMSO) TO SKIN OF GUINEA PIGS, A Histopathological Study. 1966 J. Invest. Derm. 46, 409-414 Apr 1966
    51. Willoughby, D.A., Walters, M.N. and Spector, W.G., AN ANALYSIS OF THE IRRITANT ACTION OF DIMETHYL SULFOXIDE. 1966 J. Path. Bact. 91, 195-205 Jan 1966
    52. Brown, V.K., Robinson, J. and Stevenson, D.E., A NOTE ON THE TOXICITY AND SOLVENT PROPERTIES OF DIMETHYL SULFOXIDE. 1963 J. Pharm. Pharmacol. 15, 688-692 Oct 1963
    53. Willson, J.E., Brown, D.E. and Timmens, E.K., A TOXICOLOGIC STUDY OF DIMETHYL SULFOXIDE. 1965 Toxic. Appl. Pharmacol. 7, 104-112 Jan 1965
    54. Caujolle, F., Caujolle, D., Bouyssou, H. and Calvert, M.M., PHARMACODYNAMIE-TOXICITE ET APTITUDES PHARMACOLOGIQUES DU DIMETHYLSULFOXYDE. PHARMACODYNAMICS-TOXICITY AND PHARMACOLOGICAL PROPERTIES OF DIMETHYL SULFOXIDE. 1964 C.R. Acad. Sci. Paris, 258, 2224-222617 Feb 1964
    55. Sommer, S. and Tauberger, G., TOXIKOLOGISCHE UNTERSUCHUNGEN MIT DIMETHYLSULFOXYD. TOXICOLOGIC INVESTIGATIONS WITH DIMETHYL SULFOXIDE. 1964 Arzneimittefforschung 14, 1050-1055 1964
    56. Marin-Padilla, M., MESODERMAL ALTERATIONS INDUCED BY DIMETHYL SULFOXIDE. 1966 Proc. Soc. Exp. Biol. Med. 122, 717-720 Jul 1966
    57. Caujolle, F., Caujolle, D., Cros, S., Calvert, M. and Tollon, Y., TERATOGENESE POUVOIR TERATOGENE DU DIMETHYLSULFOXIDE ET DU DIETHYLSULFOXYDE. TERATOGENESIS-TESTS OF THE TERATOGENY OF DIMETHYL SULFOXIDE AND OF DIETHYL SULFOXIDE. 1965 C.R. Acad. Sci. Paris, 260,327-330 4 Jan 1965
    58. Rubin, L.F. and Mattis, P.A., DIMETHYL SULFOXIDE, LENS CHANGES IN DOGS DURING ORAL ADMINISTRATION. 1966 Science 153, 83-84 1 Jul 1966
    59. Unpublished data 1966
    60. Stoughton, R.B., HEXACHLOROPHENE DEPOSITION IN HUMAN STRATUM CORNEUM. ENHANCEMENT BY DIMETHYLACETAMIDE, DIMETHYLSULFOXIDE, AND METHYLETHYL-ETHER. 1966 Arch. Derm. 94, 646-648 Nov 1966
    61. Katz, R. and Hood, R.W., TOPICAL THIABENDAZOLE FOR CREEPING ERUPTION. 1966 Arch. Derm. 94, 643-645 Nov 1966
    62. Sperber, P.A., TREATMENT OF CREEPING ERUPTION WITH ORALLY AND TOPICALLY ADMINISTERED THIABENDAZOLE. 1967 J. Fla. M.A., 1059-1061, Nov 1967
  • Product description:

    Indications:

    DOMOSO (dimethyl sulfoxide) Solution is recommended as a topical application to reduce acute swelling due to trauma.

    Dosing and Administration:

    DOMOSO Solution is to be administered topically to the skin over the affected area. The spray pump should be initially held approximately 6 inches from the animal and the distance adjusted to provide a uniform coverage of the area. The volume delivered by depressing the spray pump is approximately 1/3 mL. Refer to user precautions below under

    Dogs - Liberal application should be administered three to four times daily. Total daily dosage should not exceed 20 mL. Total duration of therapy should not exceed 14 days.

    PRECAUTIONS AND CONTRAINDICATIONS

    Contact between DOMOSO Solution and the skin should be avoided. Rubber gloves should be worn while applying this drug. Forceps and swabs may be used to facilitate application. If absorbed through the skin, DOMOSO Solution will cause odorous breath and unpleasant mouth taste. Mild sedation or drowsiness, sensations of warmth, burning, irritation, itching and mild erythematous localized or generalized dermatitis have been reported in some persons following exposure to DOMOSO Solution. Treatment of such side effects is symptomatic. Consult a physician immediately if adverse effects appear.

    DOMOSO Solution may mask certain disease signs such as are seen in fractures etc.; this does not obviate the need for specific therapy in such conditions. DOMOSO should not be used directly prior to racing or other physical stress wherein the drug might mask existing pathology, such as a fracture.

    Since DOMOSO Solution effectively alters the biologic membrane, it will in some cases facilitate the systemic absorption of other topically applied drugs and may have a potentiating effect on drugs administered systemically. Therefore, great care should be exercised in use of other drugs at the DOMOSO Solution application site because of the demonstrated - if variable - ability of DMSO to carry other chemicals through the dermis into the general circulation. If other topical medications are indicated they should not be applied until DOMOSO Solution is thoroughly dry. Frequently, due to the heat of resolution, a “smoking” effect following application is noted due to vaporization of the drug.

    DOMOSO Solution should also be judiciously used when administered in conjunction with other pharmaceutical preparations, especially those affecting the cardiovascular and central nervous systems. DMSO may potentiate the activity of atropine, insulin, endogenous steroids and certain other drugs.
    Lowering of the vagal threshold, spontaneous skeletal muscle fasciculation, and increased smooth muscle tone in the stomach following DMSO exposure may be due to cholinesterase inhibition. Therefore, DOMOSO Solution should not be used on dogs, or horses, simultaneously or within a few days before or after treatment with, or exposure to, cholinesterase-inhibiting pesticides or drugs.

    DOMOSO SOLUTION IS RECOMMENDED FOR TOPICAL APPLICATION ONLY. THE APPLICATION OF DOMOSO SOLUTION SHOULD TAKE PLACE ONLY IN WELL VENTILATED QUARTERS. INHALATION OF THE DRUG SHOULD BE AVOIDED. AVOID CONTACT OF THE MEDICATION WITH THE EYES.

    Keep DOMOSO Solution out of the reach of children.

    DO NOT ADMINISTER BY ANY OTHER ROUTE.

    DOMOSO Solution should not be used under occlusive dressings. DOMOSO Solution is contraindicated in horses and dogs intended for breeding purposes.

    DOMOSO Solution is a potent solvent and may have a deleterious effect on fabrics, plastics and other materials. Care should be taken to prevent physical contact with DOMOSO Solution and these materials, either alone or until drying of the treated skin surface has occurred when applied to an animal.

    CAUTION: EXTREMELY HYGROSCOPIC! CLOSE BOTTLE CAP TIGHTLY AFTER USE. AVOID FREEZING. DUE TO THE RAPID PENETRATION ABILITY OF DOMOSO, RUBBER GLOVES SHOULD BE WORN WHEN APPLYING THIS DRUG.

    Resources and Technical Information:

    REFERENCES:

    1. Kolb, K.H., Janicke, G., Kramer, M., Schulze, P.E. and Raspe, G., DAS VERHALTEN VON 35S MARKIERTEM DIMETHYLSULFOXID IM MENSCHLICHEN UND TIERISCHEN ORGANISMUS. 1965 Arzneimittel-forschung 15 1292-1295 Nov 1965
    2. Gerhands, E., Gibian, H. and Raspe, G., STOFFWECHSEL UND STOFFWECHSELWIRKUNGEN VON DIMETHYLSULFOXID. 1965 Arzeneimittel-forschung 15 1295-1297 Nov 1965
    3. Hucker, H.B., Ahmad, P.M. and Miller, E.A., PHYSIOLOGICAL DISPOSITION AND METABOLISM OF DIMETHYL SULFOXIDE, DMSO. Federation of American Societies for Experimental Biology, 49th Annual Meeting. 9-14 Apr 1965, Atlantic City. 1965 Fed. Proc. 24, 546 Mar-Apr 1965, Abstr. No. 2310
    4. DiStefano, V. and Borgstedt, H.H., REDUCTION OF DIMETHYL SULFOXIDE TO DIMETHYL SULFIDE IN THE CAT. 1964 Science 144, 1137-1138 29 May 1964
    5. Williams, K.I., Whittemore, K.S., Mellin, T.N. and Layne, D.S., OXIDATION OF DIMETHYL SULFOXIDE TO DIMETHYL SULFONE IN THE RABBIT. 1965 Science 149, 203-204 9 Jul 1965
    6. Williams, K.E., Burstein, S.H. and Layne, D.S., DIMETHYL SULFONE, ISOLATION FROM COWS MILK. 1966 Proc. Soc. Exp. Biol. Med. 122, 865-866 Jul 1966
    7. Huggins, C.E., PRESERVATION OF BLOOD FOR TRANSFUSIONS BY FREEZING WITH DIMETHYL SULFOXIDE AND A NOVEL WASHING TECHNIQUE. 1963 Surgery 54, 191-194 Jul 1963
    8. Pyle, H.M. and Boyer, H.F., EFFECTS OF DIMETHYL SULFOXIDE ON BLOOD CELLS AND BONE MARROW. 1961 Vox Sang 6, 199-200 1961
    9. Rowe, A.W., Kaczmarek, C.S. and Cohen, E., LOW TEMPERATURE PRESERVATION OF LEUKOCYTES IN DIMETHYL SULFOXIDE. Federation of American Societies for Experimental Biology, 47th Annual Meeting. 16-20 Apr 1963. Atlantic City 1963 Fed. Proc. 22, 170 1963 Abstr. No. 60
    10. Ashwood-Smith, M.J., LOW TEMPERATURE PRESERVATION OF MOUSE LYMPHOCYTES WITH DIMETHYL SULFOXIDE. 1964 Blood 23, 494-501 Apr 1964
    11. Djerassi, I. and Roy, A., A METHOD FOR PRESERVATION OF VIABLE PLATELETS, COMBINED EFFECTS OF SUGARS AND DIMETHYL SULFOXIDE. 1963 Blood 22, 703-717 1963
    12. Sawada, Y. and Chang, M.C., MOTILITY AND FERTILIZING CAPACITY OF RABBIT SPERMATOZOA AFTER FREEZING IN A MEDIUM CONTAINING DIMETHYL SULFOXIDE. 1964 Fertil. Steril. 15, 222-229 Mar-Apr 1964
    13. Zimmerman, S.J., Maude, M.B. and Moldawer, M., FREEZING AND STORAGE OF HUMAN SEMEN IN 50 HEALTHY MEDICAL STUDENTS. A Comparative Study of Glycerol and Dimethyl Sulfoxide as a Preservative. 1964 Fertil. Steril. 15, 505-510 Sep-Oct 1964
    14. Sherman, J.K., DIMETHYL SULFOXIDE AS A PROTECTIVE AGENT DURING FREEZING AND THAWING OF HUMAN SPERMATOZOA. 1964 Proc. Soc. Exp. Biol. Med. 177, 261-264 1964
    15. Mueller, F.O., Casey, T.A. and Trevor-Roper, P.D., USE OF DEEP-FROZEN HUMAN CORNEA IN FULL-THICKNESS GRAFTS. 1964 Brit. Med. J. No. 5407, 473-475 22 Aug 1964
    16. Platts, S. and Reed, H., USE OF DIMETHYL SULFOXIDE FOR PRESERVING CORNEAL TISSUE. 1963 Brit. J. Ophthal. 47, 334-338 1963
    17. Barlyn, L.W., Berggren, R.B. and Lehr, H.B., FROZEN SKIN AUTOGRAFTS PROTECTED BY DIMETHYL SULFOXIDE. 1964 Surg. Forum 15, 475-476 1964
    18. Nagington, J. and Greaves, R.I., PRESERVATION OF TISSUE CULTURE CELLS WITH LIQUID NITROGEN. 1962 Nature 194, 993-994 9 Jun 1962
    19. Porterfield, J.S. and Ashwood-Smith, M.J., PRESERVATION OF CELLS IN TISSUE CULTURE BY GLYCEROL AND DIMETHYL SULFOXIDE. 1962 Nature 193, 548-550 10 Feb 1962
    20. Lovelock, J.E. and Bishop, M.W., PREVENTION OF FREEZING DAMAGE TO LIVING CELLS BY DIMETHYL SULFOXIDE. 1959 Nature 183, 1394-1395 16 May 1959
    21. Dougherty, R.M., USE OF DIMETHYL SULFOXIDE FOR PRESERVATION OF TISSUE CULTURE CELLS BY FREEZING. 1962 Nature 193, 550-552 10 Feb 1962
    22. Walker, P.J. and Ashwood-Smith, M.J., DIMETHYL SULFOXIDE, AN ALTERNATIVE TO GLYCEROL, FOR THE LOW-TEMPERATURE PRESERVATION OF TRYPANOSOMES. 1961 Ann. Trop. Med. Parasit. 55, 93-96 1961
    23. Ashwood-Smith, M.J., INABILITY OF DIMETHYL SULFOXIDE TO PROTECT MOUSE TESTIS AGAINST THE EFFECT OF X-RADIATION. 1961 Int. J. Radiat. Biol. 3, 101-103 1961
    24. Ashwood-Smith, M.J., RADIOPROTECTIVE EFFECT OF COMBINATION OF AET OR CYSTEAMINE WITH DIMETHYL SULFOXIDE. 1962 Int. J. Radiat. Biol. 5, 201-202 May 1962
    25. Jacob, S.W., Bischel, M. and Herschler, R.J., DIMETHYL SULFOXIDE, EFFECTS ON THE PERMEABILITY OF BIOLOGIC MEMBRANES. Preliminary Report. 1964 Curr. Ther. Res. 6, 193-198 Mar 1964
    26. Jacob, S.W., Bischel, M.D., Eberle, G.A. and Herschler, R.J., THE INFLUENCE OF DIMETHYL SULFOXIDE ON THE TRANSPORT OF INSULIN ACROSS A BIOLOGIC MEMBRANE. Federation of American Societies for Experimental Biology, 48th Annual Meeting. 12-17 Apr 1964 Chicago. 1964 Fed. Proc. 23, 410 Mar-Apr 1964 Abstr. No. 1850
    27. Stoughton, R.B. and Fritsch, W., INFLUENCE OF DIMETHYL SULFOXIDE (DMSO) ON HUMAN PERCUTANEOUS ABSORPTION. Archives of Dermatology 90:512 Nov 1964
    28. Kligman, A.M., TOPICAL PHARMACOLOGY AND TOXICOLOGY OF DIMETHYL SULFOXIDE - PART I. 1965 J. Amer. Med. Assoc. 193, 796-804 6 Sep 1965
    29. Kligman, A.M., TOPICAL PHARMACOLOGY AND TOXICOLOGY OF DIMETHYL SULFOXIDE - PART II. 1965 J. Amer. Med. Assoc. 193, 923-928 13 Sep 1965
    30. Leake, C.D., DIMETHYL SULFOXIDE. Science 152, 1646-1649 17 Jun 1966
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CAUTION:

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

For more safety information, please refer to the full Prescribing Information.