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A SAFE AND MILD STANDING SEDATIVE
You know your horse better than anyone. Not every horse needs DORMOSEDAN GEL® (detomidine hydrochloride) for every procedure. But for those occasions when your horse is nervous, frightened or won’t cooperate, DORMOSEDAN GEL is an easy-to-use solution.

Prescribed by your veterinarian, DORMOSEDAN GEL is a safe, effective way for horse owners to administer a mild standing sedative. Available in single-dose syringes, the oral gel formulation is convenient and safe for a wide variety of procedures.

Use DORMOSEDAN GEL prior to stressful situations and minor nonpainful procedures, such as:

  • Shoeing or trimming
  • Clipping
  • Pulling a mane
  • Sheath cleaning
  • First time turnouts

HOW IT WORKS
Detomidine, the active ingredient in DORMOSEDAN GEL, is a potent and relatively selective alpha 2 adrenoceptor agonist with a central effect inhibiting the transmission of norepinephrine-mediated nervous impulses. When administered to the animal, the level of consciousness is lowered. The well-characterized profile of detomidine at the receptor level explains its predictable, dose-dependent pharmacological effects.

How it works

Figure 1: Normal Nerve Transmission
Norepinephrine is released and binds with alpha 1 (α1) and alpha 2 (α2) adrenoceptors to send a nerve impulse or cause a muscle to contract.

Figure 2: Administration of DORMOSEDAN GEL
Administration of DORMOSEDAN GEL results in mild sedation. DORMOSEDAN GEL selectively binds to the α2 adrenoceptors, causing the nerve to stop releasing norepinephrine and blocking the nerve impulse.

IMPORTANT SAFETY INFORMATION
Do not use DORMOSEDAN GEL in horses with pre-existing atrioventricular (AV) or sinoatrial (SA) block, with severe coronary insufficiency, cerebrovascular disease, respiratory disease, or chronic renal failure. Do not use in anesthetized or sedated horses, or in conditions of shock, severe debilitation or stress due to extreme heat, cold, fatigue or high altitude. Do not use in horses intended for human consumption. Handle gel-dosing syringes with caution to avoid direct exposure to skin, eyes or mouth. See full Prescribing Information.

DOR-00069