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KETOFEN® Sterile Solution


Equine Pain and Inflammation Relief


KETOFEN® Sterile Solution is recommended for the alleviation of inflammation and pain associated with musculoskeletal disorders in horses. The product is an FDA-approved non-narcotic, nonsteroidal anti-inflammatory agent with analgesic and antipyretic properties.

As part of the trusted equine pain and sedation portfolio from Zoetis, KETOFEN is safe and effective against equine pain and inflammation. Hoof pain associated with chronic laminitis is significantly reduced for up to six hours with KETOFEN.1

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    • FDA-approved non-narcotic, nonsteroidal anti-inflammatory agent recommended for the alleviation of inflammation and pain associated with musculoskeletal disorders in horses
    • Significantly reduces hoof pain associated with chronic laminitis for up to six hours1
    • Showed significant intra-articular anti-inflammatory activity in an experimentally induced acute carpal synovitis model2
    • Therapeutically equivalent to flunixin meglumine in the alleviation of pain in carpal model of arthritis3
    • NSAID of the propionic acid class that includes ibuprofen, naproxen and fenoprofen
    • 1 mg/lb. (1 mL/100 lbs.) of body weight, once daily
      • Administer by intravenous injection
      • May be repeated for up to five days
    • Onset of activity is within two hours with peak response by 12 hours and still measurable at 24 hours


    • 50-mL vial
    • 100-mL vial

    There are no known contraindications to this drug when used as directed. Intra-arterial injection should be avoided. Do not use in a horse if it has previously shown hypersensitivity to ketoprofen.

    Federal law restricts this drug to use by or on the order of a licensed veterinarian.
    For intravenous use in horses only.
    This product should not be used in breeding animals since the effects of KETOFEN on fertility, pregnancy or fetal health in horses have not been determined.

    Studies to determine activity of KETOFEN when administered concomitantly with other drugs have not been conducted. Drug compatibility should be monitored closely in patients requiring adjunctive therapy.

  • 1 Owens JG, Kamerling SG, Stanton SR, Keowen ML. Effects of ketoprofen and phenylbutazone on chronic hoof pain and lameness in the horse. Equine Vet J. 1995;27(4):296-300.
    2 Owens JG, Kamerling SG, Barker SA. Pharmacokinetics of ketoprofen in healthy horses and those with acute synovitis. J Vet Pharmacol Ther. 1995;18(3):187-195.
    3 Longo E, Autefage A, Bayle R, Keister M, Van Gool E. Efficacy of a nonsteroidal anti-inflammatory, ketofen 10% (ketoprofen) in the treatment of colic in horses. J Equine Vet Sci. 1992;12(5):311-315.

IMPORTANT SAFETY INFORMATION: KETOFEN should not be used in breeding horses. Do not use in horses intended for human consumption. See full Prescribing Information.




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