NEW LABEL UPDATE
Now with a revised label to extend use beyond 5 days.
Prevent Emesis as Long as Needed
CERENIA® (maropitant citrate) Tablets are now approved for use until resolution of acute vomiting in dogs 7 months and older.
Steady State Levels Reached by Day Four in 14-day Pharmacokinetics Study13
In a 14-day repeat dose pharmacokinetics study in laboratory dogs, the time to reach steady state levels of maropitant metabolite was approximately 4 days for daily 2 mg/kg oral dosing. Steady state pharmacokinetics confirms that the rate of drug accumulation equals the rate of drug elimination.
Extended Dosing Safety
In a laboratory safety study, 24 dogs 7 months of age were randomized into four groups of equal genders and given maropitant at O, 1, 5 or 2O mg/kg/day, once daily for 93 days. In the 2O mg/kg/day group, sporadic clinical signs (salivation, emesis), body weight loss and lower serum albumin levels, as well as increased P-R interval, P wave duration and QRS amplitude were noted. These effects were not noted in the other dosing groups.
This study supports the safe use of maropitant citrate at a dose of 2mg/kg (0.9 mg/lb) body weight once daily as long as needed.
IMPORTANT SAFETY INFORMATION: Use CERENIA Injectable for vomiting in cats 4 months and older; use subcutaneously for acute vomiting in dogs 2 to 4 months of age or either subcutaneously or intravenously in dogs 4 months of age and older. Use CERENIA Tablets for acute vomiting in dogs 2 months and older, and for prevention of vomiting due to motion sickness in dogs 4 months and older. Safe use has not been evaluated in cats and dogs with gastrointestinal obstruction, or those that have ingested toxins. Use with caution in cats and dogs with hepatic dysfunction. Pain/vocalization upon injection is a common side effect. In people, topical exposure may elicit localized allergic skin reactions, and repeated or prolonged exposure may lead to skin sensitization. Please see full Prescribing Information.
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