Make CERENIA a Part of Your Preoperative Protocol When Using Opioids
CERENIA® (maropitant citrate) is the only FDA-approved medication for the prevention of acute emesis in dogs. Emetogenic agents such as opioids can cause acute emesis. You use opioids as preanesthetics. As you know, a significant number of dogs experience vomiting following the administration of some opioids.1O In a recent study, CERENIA was used preoperatively to prevent vomiting.11
In a blinded, placebo-controlled study, with Cerenia dosed 45 minutes prior to the preoperative administration of morphine, results demonstrated a significant (p<O.O5) difference in the incidence of vomiting for CERENIA-treated dogs (n=15) compared to the placebo-treated dogs (n=16).11
The study included 31 dogs: 15 CERENIA-treated and 16 placebo-treated. Dogs received either CERENIA (1 mg/kg SQ) or saline 45 minutes prior to the preoperative administration of morphine (O.5 mg/kg SQ). Vomiting events were recorded for 3O minutes until propofol induction. All dogs underwent a routine spay or neuter under isoflurane. Dogs were offered their normal dry diet at 2, 3, 6 and 2O hours post-surgery.
New data demonstrate preoperative efficacy in prevention of vomiting caused by opioids
- Vomiting: Events were recorded for 3O minutes post-administration of morphine.
- Return to normal feeding: Defined as the time 1OO grams of food had been consumed.
- Total food consumption: The amount of food eaten by 2O hours.
Return to feeding:
The study showed that significantly (p<O.O5) more CERENIA-treated dogs returned to normal feeding† at 2O hours than placebo-treated dogs.
The study showed a significantly (p<O.O5) higher mean total food consumption. CERENIA-treated dogs consumed 4.85 times as much food: 19O.O grams versus 39.1 grams.
IMPORTANT SAFETY INFORMATION: Use CERENIA Injectable for vomiting in cats 4 months and older; use subcutaneously for acute vomiting in dogs 2 to 4 months of age or either subcutaneously or intravenously in dogs 4 months of age and older. Use CERENIA Tablets for acute vomiting in dogs 2 months and older, and for prevention of vomiting due to motion sickness in dogs 4 months and older. Safe use has not been evaluated in cats and dogs with gastrointestinal obstruction, or those that have ingested toxins. Use with caution in cats and dogs with hepatic dysfunction. Pain/vocalization upon injection is a common side effect. In people, topical exposure may elicit localized allergic skin reactions, and repeated or prolonged exposure may lead to skin sensitization. Please see full Prescribing Information.
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