Extended therapy with EXCEDE®

  • EXCEDE® (ceftiofur crystalline free acid) Sterile Suspension offers extended therapy in a single dose for the treatment of Fusobacterium necrophorum and Porphyromonas levii, two primary foot rot-causing bacteria.1,2
  • EXCEDE is also labeled for the treatment of bovine respiratory disease (BRD/pneumonia) associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus somni.
  • Extended therapy with EXCEDE reduces labor costs, hospital pen exposure and performance losses, because cows remain in the milking string.1
Residue Free Guarantee
Instance of abnormal locomotion scores  in heifers vs. fresh heifers

Foot rot impacts your herd

Foot rot is a leading cause of lameness. A single case is estimated to cost dairy operations up to $446 per cow and increases the risk of culling, especially during the first half of lactation.3

Researchers found 23 percent of heifers (16 days pre-calving) had abnormal locomotion scores compared with 53 percent of fresh heifers (37 days in milk), demonstrating the incidence of lameness can increase by almost 30 percent in fresh cows, (Figure 1).4

BRD — A devastating disease

Respiratory disease in cattle can be caused by a range of factors, whether singly or a combination. A major cause of economic losses, BRD affects the lower respiratory tract/lungs (pneumonia) or upper respiratory tract (rhinitis, tracheitis, bronchitis).

  • In the U.S. dairy industry, respiratory disease is the leading cause of illness and death in weaned calves.5 Morbidity due to BRD affects survivability while reducing dairy performance later in life.
  • Economic losses include death loss, decreased weight gain and additional labor and treatment costs.
Leading causes of weaned heifer deaths

Important Safety Information: As with all drugs, the use of EXCEDE is contraindicated in animals with known allergy to ceftiofur or to the ß-lactam group (penicillins and cephalosporins) of antimicrobials. Though safe in cattle when properly administered, inadvertent intra-arterial injection is possible and fatal. EXCEDE has a pre-slaughter withdrawal time of 13 days following the last dose in cattle. Do not use in calves to be processed for veal.


  1. Van Donkersgoed J, Dussault M, Knight P, Byers L, Takara M, Darien B. Clinical efficacy of a single injection of ceftiofur crystalline free acid sterile injectable suspension versusthree daily injections of ceftiofur sodium sterile powder for the treatment of foot rot in feedlot cattle. vetlearn.com, December 31, 2007.
  2. Data on file, Study Report Nos. 820-9690-94-004 and 1133C-60-05-505, Zoetis Inc.
  3. Booth CJ, Warnick LD, Grohn YT, Maizon DO, Guard CL and Janssen D. Effect of lameness on culling in dairy cows. J Dairy Sci 2004;87:4115-4122
  4. Cook N. Lameness is a fresh cow disease. Cow Comfort Consortium Newsletter 2010;1(3).
  5. USDA. Heifer Calf Health Management Practices on U.S. Dairy Operations. 2007. #N55.0110
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